Success Stories

Since June 2006, 8 faculty have graduated from the COBRE when they obtained their own R01 grant from NIH.

Bryan Copple, Ph.D.
R01 Title:  “Role of Early Growth Response Factor-1 in Cholestatic Liver Injury”
Funded by:  Diabetetes & Digestive & Kidney Diseases (NIDDK)
COBRE Mentors:  Curtis D. Klaassen, Ph.D. & Yu-Jui Yvonne Wan, Ph.D.

Wen-Xing Ding, Ph.D.
R01 Title:  “Mechanisms Regulating Autophagy in Alcohol Induced Liver Injury”
Funded by:  Alcohol Abuse & Alcoholism (NIAAA)
COBRE Mentors:  Hartmut Jaeschke, Ph.D.. & Yu-Jui Yvonne Wan, Ph.D.

Grace Guo, Ph.D.
R01 Title:  “Tissue specific mechanism of FXR in suppressing bile-acid synthesis”
Funded by:  Diabetetes & Digestive & Kidney Diseases (NIDDK)
COBRE Mentors:  Beth Levant, Ph.D. & Ken Peterson Ph.D.

Bruno Hagenbuch, Ph.D.
R01 Title:  “Molecular Characterization of Hepatic Organic Anion Transporting Polypeptides”
Funded by:  National Institute of General Medicine Sciences (NIGMS)
COBRE Mentors:  Glen Andrews, Ph.D. & Curtis Klaassen, Ph.D.

James Luyendyk, Ph.D.
R01 Title:  “Mechanisms of xenobiotic-induced biliary inflammation and fibrosis”
Funded by:  National Institute of Enviornmental Health Sciences (NIEHS)
COBRE Mentors:  Hartmut Jaeschke, Ph.D. & Bao-Ting Zhu, Ph.D.

Xiaochao Ma, Ph.D.
R01 Title:  “Mechanisms of adverse effects of anti-tuberculosis drugs”
Funded by: Diabetetes & Digestive & Kidney Diseases (NIDDK)
COBRE Mentors: Grace Guo, Ph.D. & Steven Weinman, M.D., Ph.D.

Li Wang, Ph.D.
R01 Title:  “SHP regulation of lipid and lipoprotein metabolism"
Funded by: Diabetetes & Digestive & Kidney Diseases (NIDDK)
COBRE Mentors:  Glen Andrews, Ph.D. & Curt Hagedorn, M.D.

Xiaobo Zhong, Ph.D.
R01 Title:  “Control of developmental switch of Cyp3a gene expression in mouse liver”
Funded by:  National Institute of General Medicine Sciences (NIGMS)

R01 Title:  “Developmental Regulation of Drug Processing Genes”
Funded by:  National Institute of Enviornmental Health Sciences (NIEHS)
COBRE Mentors:  Curtis D. Klaassen, Ph.D. & Yu-Jui Yvonne Wan, Ph.D.