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ACL Publications

Peer reviewed publications that the ACL has contributed to:

2017 Publications

  • Funk, R.S., Singh, R.K., Winefield, R.D., Kandel, S.E., Ruisinger, J.F., Moriarty, P.M., and Backes,, J.M. "Variability in Potency among Commercial Preparations of Berberine." (2017) J. Diet Suppl. doi: 10.1080/19390211

  • Chavan, H., Christudoss, P., Mickey, K., Tessman, R., Ni, H. M., Swerdlow, R., Krishnamurthy, P. (2017) "Arsenite effects on mitochondrial bioenergetics in human and mouse primary hepatocytes follows a non-linear dose response." Oxidative Medicine and Cellular Longevity. 2017:9251303.

2016 Publications

  • Braghini, C.A., Costa, F.C., Fedosyuk, H., Neades, R.Y., Novikova, L.V., Parker, M.P., Winefield, R.D., Peterson, K.R. (2016) "Generation of non-deletional hereditary persistence of fetal hemoglobin β-globin locus yeast artificial chromosome transgenic mouse models: -175 Black HPFH and -195 Brazilian HPFH." Experimental biology and medicine (Maywood, N.J.). 241(7): 697-705 

2015 Publications

  • Pondugula, S. R., P. C. Flannery, U. Apte, J. R. Babu, T. Geetha, S. D. Rege, T. Chen and K. L. Abbott (2015). "Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression." Drug Metab Dispos 43(3): 385-391.

  • Xie, Y., McGill, M.R., Cook, S.F., Sharpe, M.R., Winefield, R.D., Wilkins, D.G., Rollins, D.E., Jaeschke, H. (2015) "Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients" Xenobiotica 45(10): 921-929.

  • Winefield, R.D., Heemskerk, A.A., Kaul, S., Williams, T.D., Caspers, M.J., Prisinzano, T.E., McCance-Katz, E.F., Lunte, C.E., Faiman, M.D. (2015) "N-Acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration." Journal of Pharmaceutical and Biomedical Analysis.107: 518-525. 

2014 Publications

  • Bhushan, B., C. Walesky, M. Manley, T. Gallagher, P. Borude, G. Edwards, S. Du, K., C. D. Williams, M. R. McGill and H. Jaeschke (2014). "Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase." Toxicol Appl Pharmacol 281(1): 58-66.

  • Chavan, H., F. Li, R. Tessman, K. Mickey, K. Dorko, T. Schmitt, S. Kumer, S. Gunewardena, N. Gaikwad and P. Krishnamurthy (2015). "Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver." J Biol Chem 290(12): 7871-7886.

  • Cheng, X., Y. Zhang and C. D. Klaassen (2014). "Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum." J Pharmacol Exp Ther 351(1): 105-113.

  • Kong, B., J. Huang, Y. Zhu, G. Li, J. Williams, S. Shen, L. M. Aleksunes, J. R. Richardson, U. Apte, D. A. Rudnick and G. L. Guo (2014). "Fibroblast growth factor 15 deficiency impairs liver regeneration in mice." Am J Physiol Gastrointest Liver Physiol 306(10): G893-902.

  • Li, F., J. Lu and X. Ma (2014). "CPY3A4-mediated alpha-hydroxyaldehyde formation in saquinavir metabolism." Drug Metab Dispos 42(2): 213-220.

  • Li, J., L. Bi, M. Hulke and T. Li (2014). "Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice." J Biol Chem 289(32): 22437-22449.

  • Liang, N., C. Zhang, P. Dill, G. Panasyuk, D. Pion, V. Koka, M. Gallazzini, E. N. Olson, H. Lam, E. P. Henske, Z. Dong, U. Apte, N. Pallet, R. L. Johnson, F. Terzi, D. J. Kwiatkowski, J. Y. Scoazec, G. Martignoni and M. Pende (2014). "Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex." J Exp Med 211(11): 2249-2263.

  • Liu, K., F. Li, J. Lu, S. Liu, K. Dorko, W. Xie and X. Ma (2014). "Bedaquiline metabolism: enzymes and novel metabolites." Drug Metab Dispos 42(5): 863-866.

  • McGill, M. R., F. Li, M. R. Sharpe, C. D. Williams, S. C. Curry, X. Ma and H. Jaeschke (2014). "Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans." Arch Toxicol 88(2): 391-401.

  • Manley, S., H. M. Ni, J. A. Williams, B. Kong, L. DiTacchio, G. Guo and W. X. Ding (2014). "Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity." Redox Biol 2C: 991-1002.

  • Monga, P. and U. Apte (2014). "Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model." Am J Pathol 184(11): 3013-3025.

  • Ni, H. M., A. Bhakta, S. Wang, Z. Li, S. Manley, H. Huang, B. Copple and W. X. Ding (2014). "Role of hypoxia inducing factor-1beta in alcohol-induced autophagy, steatosis and liver injury in mice." PLoS One 9(12): e115849.

  • Ohnishi, S., A. Hays and B. Hagenbuch (2014). "Cysteine scanning mutagenesis of transmembrane domain 10 in organic anion transporting polypeptide 1B1." Biochemistry 53(14): 2261-2270.

  • Raveendran, V. V., K. M. Kassel, D. D. Smith, J. P. Luyendyk, K. J. Williams, R. Cherian, G. A. Reed, C. A. Flynn, I. L. Csanaky, A. L. Lickteig, M. J. Pratt-Hyatt, C. D. Klaassen and K. N. Dileepan (2014). "H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice." Am J Physiol Gastrointest Liver Physiol 307(2): G219-228.

  • Raveendran, V. V., D. D. Smith, X. Tan, M. E. Sweeney, G. A. Reed, C. A. Flynn, O. W. Tawfik, G. Milne and K. N. Dileepan (2014). "Chronic ingestion of H1-antihistamines increase progression of atherosclerosis in apolipoprotein E-/- mice." PLoS One 9(7): e102165.

  • Renaud, H. J., J. Y. Cui, H. Lu and C. D. Klaassen (2014). "Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis." PLoS One 9(2): e88584.

  • Saha, S. K., C. A. Parachoniak, K. S. Ghanta, J. Fitamant, K. N. Ross, M. S. Najem, S. Gurumurthy, E. A. Akbay, D. Sia, H. Cornella, O. Miltiadous, C. Walesky, V. Deshpande, A. X. Zhu, A. F. Hezel, K. E. Yen, K. S. Straley, J. Travins, J. Popovici-Muller, C. Gliser, C. R. Ferrone, U. Apte, J. M. Llovet, K. K. Wong, S. Ramaswamy and N. Bardeesy (2014). "Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer." Nature 513(7516): 110-114.

  • Ward, J., C. Kanchagar, I. Veksler-Lublinsky, R. C. Lee, M. R. McGill, H. Jaeschke, S. C. Curry and V. R. Ambros (2014). "Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis." Proc Natl Acad Sci U S A 111(33): 12169-12174.

  • Williams, C. D., M. R. McGill, M. Lebofsky, M. L. Bajt and H. Jaeschke (2014). "Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning." Toxicol Appl Pharmacol 274(3): 417-424.

  • Woolbright, B. L., F. Li, Y. Xie, A. Farhood, P. Fickert, M. Trauner and H. Jaeschke (2014). "Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice." Toxicol Lett 228(1): 56-66.

  • Woolbright, B. L., M. R. McGill, V. S. Staggs, R. D. Winefield, P. Gholami, M. Olyaee, M. R. Sharpe, S. C. Curry, W. M. Lee, H. Jaeschke and G. Acute Liver Failure Study (2014). "Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients." Toxicol Sci 142(2): 436-444.

  • Zhang, Y., P. B. Limaye, H. J. Renaud and C. D. Klaassen (2014). "Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice." Toxicol Appl Pharmacol 277(2): 138-145.

  • Yang, M., A. Ramachandran, H. M. Yan, B. L. Woolbright, B. L. Copple, P. Fickert, M. Trauner and H. Jaeschke (2014). "Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice." Toxicol Lett 224(2): 186-195. 

2013 Publications

  • Bhushan, B., P. Borude, G. Edwards, C. Walesky, J. Cleveland, F. Li, X. Ma and U. Apte (2013). "Role of bile acids in liver injury and regeneration following acetaminophen overdose." Am J Pathol 183(5): 1518-1526.

  • Bi, L., J. Y. Chiang, W. X. Ding, W. Dunn, B. Roberts and T. Li (2013). "Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice." J Lipid Res54(10): 2754-2762.

  • Fukui, M., K. S. Kang, K. Okada and B. T. Zhu (2013). "EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction." J Cell Biochem114(1): 192-203.

  • Liu, J., Y. F. Lu, Y. Zhang, K. C. Wu, F. Fan and C. D. Klaassen (2013). "Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice." Toxicol Appl Pharmacol272(3): 816-824.

  • Li, F., J. Lu, J. Cheng, L. Wang, T. Matsubara, I. L. Csanaky, C. D. Klaassen, F. J. Gonzalez and X. Ma (2013). "Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy." Nat Med19(4): 418-420.

  • Ramachandran, A., M. R. McGill, Y. Xie, H. M. Ni, W. X. Ding and H. Jaeschke (2013). "Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice." Hepatology58(6): 2099-2108.

  • Jiang, X. R., P. Wang, C. L. Smith and B. T. Zhu (2013). "Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity." J Med Chem56(7): 2779-2790.

  • Walesky, C., S. Gunewardena, E. F. Terwilliger, G. Edwards, P. Borude and U. Apte (2013). "Hepatocyte-specific deletion of hepatocyte nuclear factor-4alpha in adult mice results in increased hepatocyte proliferation." Am J Physiol Gastrointest Liver Physiol304(1): G26-37.

  • Williams, C. D., M. R. McGill, A. Farhood and H. Jaeschke (2013). "Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress." Food Chem Toxicol58: 228-235.

  • Zhang, Y., I. L. Csanaky, F. P. Selwyn, L. D. Lehman-McKeeman and C. D. Klaassen (2013). "Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism." Biochem Pharmacol86(3): 437-445.

2012 Publications

  • Borude, P., G. Edwards, C. Walesky, F. Li, X. Ma, B. Kong, G. L. Guo and U. Apte (2012). "Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice." Hepatology 56(6): 2344-2352.

  • Chavan, H. and P. Krishnamurthy (2012). "Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR)." J Biol Chem 287(38): 32054-32068.

  • Cui, J. Y., L. M. Aleksunes, Y. Tanaka, Z. D. Fu, Y. Guo, G. L. Guo, H. Lu, X. B. Zhong and C. D. Klaassen (2012). "Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice." Am J Physiol Gastrointest Liver Physiol 302(9): G979-996.

  • Kong, B., I. L. Csanaky, L. M. Aleksunes, M. Patni, Q. Chen, X. Ma, H. Jaeschke, S. Weir, M. Broward, C. D. Klaassen and G. L. Guo (2012). "Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity." Toxicol Appl Pharmacol 261(2): 189-195.

  • Li, F., J. Lu and X. Ma (2012). "CYP3A4-mediated lopinavir bioactivation and its inhibition by ritonavir." Drug Metab Dispos 40(1): 18-24.

  • Li, H., A. Wolfe, S. Septer, G. Edwards, X. Zhong, A. B. Abdulkarim, S. Ranganathan and U. Apte (2012). "Deregulation of Hippo kinase signalling in human hepatic malignancies." Liver Int 32(1): 38-47.

  • Polireddy, K., M. M. Khan, H. Chavan, S. Young, X. Ma, A. Waller, M. Garcia, D. Perez, S. Chavez, J. J. Strouse, M. K. Haynes, C. G. Bologa, T. I. Oprea, G. P. Tegos, L. A. Sklar and P. Krishnamurthy (2012). "A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6." PLoS One 7(7): e40005.

  • Septer, S., G. Edwards, S. Gunewardena, A. Wolfe, H. Li, J. Daniel and U. Apte (2012). "Yes-associated protein is involved in proliferation and differentiation during postnatal liver development." Am J Physiol Gastrointest Liver Physiol 302(5): G493-503.

  • Zhang, Y., I. L. Csanaky, X. Cheng, L. D. Lehman-McKeeman and C. D. Klaassen (2012). "Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury." Toxicol Sci 127(2): 451-462.

  • Zhang, Y., J. Y. Hong, C. E. Rockwell, B. L. Copple, H. Jaeschke and C. D. Klaassen (2012). "Effect of bile duct ligation on bile acid composition in mouse serum and liver." Liver Int 32(1): 58-69.

  • Zhang, Y., P. B. Limaye, L. D. Lehman-McKeeman and C. D. Klaassen (2012). "Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice." PLoS One 7(4): e34522.

2011 Publications

  • Allen, K., H. Jaeschke and B. L. Copple (2011). "Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis." Am J Pathol 178(1): 175-186.

  • Chavan, H., M. Oruganti and P. Krishnamurthy (2011). "The ATP-binding cassette transporter ABCB6 is induced by arsenic and protects against arsenic cytotoxicity." Toxicol Sci 120(2): 519-528.

  • Choi, H. J., K. S. Kang, M. Fukui and B. T. Zhu (2011). "Critical role of the JNK-p53-GADD45alpha apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons." Br J Pharmacol 162(1): 175-192.

  • Csanaky, I. L., H. Lu, Y. Zhang, K. Ogura, S. Choudhuri and C. D. Klaassen (2011). "Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice." Hepatology 53(1): 272-281.

  • Flynn, C. A., Y. Alnouti and G. A. Reed (2011). "Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry." Rapid Commun Mass Spectrom 25(16): 2361-2366.

  • Fu, X. M., P. Wang and B. T. Zhu (2011). "Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl group." Biochemistry 50(1): 106-115.

  • Gor, P., Y. Alnouti and G. A. Reed (2011). "Buspirone, fexofenadine, and omeprazole: quantification of probe drugs and their metabolites in human plasma." J Pharm Biomed Anal 55(5): 1127-1135.

  • Kassel, K. M., A. P. Owens, 3rd, C. E. Rockwell, B. P. Sullivan, R. Wang, O. Tawfik, G. Li, G. L. Guo, N. Mackman and J. P. Luyendyk (2011). "Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet." Am J Pathol 179(5): 2278-2289.

  • Levant, B., T. J. Zarcone, P. F. Davis, M. K. Ozias and S. C. Fowler (2011). "Differences in methylphenidate dose response between periadolescent and adult rats in the familiar arena-novel alcove task." J Pharmacol Exp Ther 337(1): 83-91.

  • Li, F., J. Lu, L. Wang and X. Ma (2011). "CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism." Drug Metab Dispos 39(3): 394-401.

  • Li, F., Y. Miao, L. Zhang, S. A. Neuenswander, J. T. Douglas and X. Ma (2011). "Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine." Drug Metab Pharmacokinet 26(6): 569-576.

  • Li, F., J. Lu and X. Ma (2011). "Metabolomic screening and identification of the bioactivation pathways of ritonavir." Chem Res Toxicol 24(12): 2109-2114.

  • Li, F., J. Lu and X. Ma (2011). "Profiling the reactive metabolites of xenobiotics using metabolomic technologies." Chem Res Toxicol 24(5): 744-751.

  • Luyendyk, J. P., K. C. Flanagan, C. D. Williams, H. Jaeschke, J. G. Slusser, N. Mackman and G. H. Cantor (2011). "Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice." Toxicol Appl Pharmacol 250(3): 256-262.

  • McGill, M. R., H. M. Yan, A. Ramachandran, G. J. Murray, D. E. Rollins and H. Jaeschke (2011). "HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity." Hepatology 53(3): 974-982.

  • Obaidat, A., J. Weiss, B. Wahlgren, R. R. Manam, V. R. Macherla, K. McArthur, T. H. Chao, M. A. Palladino, G. K. Lloyd, B. C. Potts, S. J. Enna, S. T. Neuteboom and B. Hagenbuch (2011). "Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs." J Pharmacol Exp Ther 337(2): 479-486.

  • Polireddy, K., H. Chavan, B. A. Abdulkarim and P. Krishnamurthy (2011). "Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma." Mol Oncol 5(5): 410-425.

  • Roth, M., B. N. Timmermann and B. Hagenbuch (2011). "Interactions of green tea catechins with organic anion-transporting polypeptides." Drug Metab Dispos 39(5): 920-926.

  • Song, P., Y. Zhang and C. D. Klaassen (2011). "Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice." Toxicol Sci 123(2): 359-367.

  • Williams, C. D., D. J. Antoine, P. J. Shaw, C. Benson, A. Farhood, D. P. Williams, T. D. Kanneganti, B. K. Park and H. Jaeschke (2011). "Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury." Toxicol Appl Pharmacol 252(3): 289-297.

  • Wolfe, A., A. Thomas, G. Edwards, R. Jaseja, G. L. Guo and U. Apte (2011). "Increased activation of the Wnt/beta-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice." J Pharmacol Exp Ther 338(1): 12-21.

  • Zhang, Y., I. L. Csanaky, L. D. Lehman-McKeeman and C. D. Klaassen (2011). "Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability." Toxicol Sci 124(2): 251-260.

  • Zhang, Y. K., G. L. Guo and C. D. Klaassen (2011). "Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters." PLoS One 6(2): e16683.

  • Zhang, E. Y., J. Xiong, B. L. Parker, A. Y. Chen, P. E. Fields, X. Ma, J. Qiu and T. M. Yankee (2011). "Depletion and recovery of lymphoid subsets following morphine administration." Br J Pharmacol 164(7): 1829-1844.

2010 Publications

  • Fukui, M., N. Yamabe, K. S. Kang and B. T. Zhu (2010). "Growth-stimulatory effect of resveratrol in human cancer cells." Mol Carcinog 49(8): 750-759.

  • Li, F., L. Wang, G. L. Guo and X. Ma (2010). "Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice." Drug Metab Dispos 38(5): 871-878.

  • Luyendyk, J. P., B. P. Sullivan, G. L. Guo and R. Wang (2010). "Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice." Am J Pathol 176(1): 177-186.

  • Niu, S., F. Li, D. X. Tan, L. Zhang, J. R. Idle, F. J. Gonzalez and X. Ma (2010). "Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice." J Pineal Res 49(2): 106-114.

  • Saito, C., J. J. Lemasters and H. Jaeschke (2010). "c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity." Toxicol Appl Pharmacol 246(1-2): 8-17.

  • Saito, C., H. M. Yan, A. Artigues, M. T. Villar, A. Farhood and H. Jaeschke (2010). "Mechanism of protection by metallothionein against acetaminophen hepatotoxicity." Toxicol Appl Pharmacol 242(2): 182-190.

  • Wang, L., F. Li, J. Lu, G. Li, D. Li, X. B. Zhong, G. L. Guo and X. Ma (2010). "The Chinese herbal medicine Sophora flavescens activates pregnane X receptor." Drug Metab Dispos 38(12): 2226-2231.

  • Weaver, B. P., Y. Zhang, S. Hiscox, G. L. Guo, U. Apte, K. M. Taylor, C. T. Sheline, L. Wang and G. K. Andrews (2010). "Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration." PLoS One 5(10).

  • Weaver, Y. M., D. J. Ehresman, J. L. Butenhoff and B. Hagenbuch (2010). "Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths." Toxicol Sci 113(2): 305-314.

  • Williams, C. D., M. L. Bajt, A. Farhood and H. Jaeschke (2010). "Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice." Liver Int 30(9): 1280-1292.

  • Williams, C. D., A. Farhood and H. Jaeschke (2010). "Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury." Toxicol Appl Pharmacol 247(3): 169-178.

  • Zhang, Y. and C. D. Klaassen (2010). "Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice." J Lipid Res 51(11): 3230-3242.

2009 Publications

  • Baker, A. K., R. Wang, N. Mackman and J. P. Luyendyk (2009). "Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression." Mol Immunol 46(11-12): 2249-2255.

  • Luyendyk, J. P., G. H. Cantor, D. Kirchhofer, N. Mackman, B. L. Copple and R. Wang (2009). "Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice." Am J Physiol Gastrointest Liver Physiol 296(4): G840-849.

  • Zhu, B. T., P. Wang, M. Nagai, Y. Wen and H. W. Bai (2009). "Inhibition of human catechol-O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee." J Steroid Biochem Mol Biol 113(1-2): 65-74.

2008 Publications

  • Bai, H. W. and B. T. Zhu (2008). "Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids." J Lipid Res 49(12): 2557-2570.

  • Reed, G. A., J. M. Sunega, D. K. Sullivan, J. C. Gray, M. S. Mayo, J. A. Crowell and A. Hurwitz (2008). "Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects." Cancer Epidemiol Biomarkers Prev 17(10): 2619-2624.

  • Zhu, B. T. (2008). "Is it necessary to control the level of estrogen receptor alpha and beta activation in postmenopausal hormone replacement therapy in order to achieve the optimal outcome? (Review)." Mol Med Rep 1(1): 15-20.

2007 Publications

  • Alnouti, Y. M., M. K. Shelby, C. Chen and C. D. Klaassen (2007). "Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine." Curr Drug Metab 8(1): 79-89.

  • Chen, A. Y., A. J. Lee, X. R. Jiang and B. T. Zhu (2007). "Chemical synthesis of six novel 17beta-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms." J Med Chem 50(22): 5372-5381.

2006 Publications

  • Dai, G., L. He, N. Chou and Y. J. Wan (2006). "Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse." Toxicol Sci 92(1): 33-41.

  • Reed, G. A., D. W. Arneson, W. C. Putnam, H. J. Smith, J. C. Gray, D. K. Sullivan, M. S. Mayo, J. A. Crowell and A. Hurwitz (2006). "Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane." Cancer Epidemiol Biomarkers Prev 15(12): 2477-2481.


Last modified: Sep 28, 2018