The ACL was founded as a shared equipment laboratory (a Core laboratory) around 2008 as part of a Center for Biomedical Research Excellence (COBRE) grant awarded to the department of Pharmacology, Toxicology and Therapeutics in 2006. This COBRE grant was renewed for the third and final time in 2016 (P30GM118247).
The ACL maintains a varied instrument suite designed to assist KUMC's basic research community by providing access to the advanced instrumentation needed to examine toxicants, endogenous metabolites, biotherapeutic compounds and the products of their metabolic break-down. Stated more simply, the ACL's mission is to assist with the execution of quantitative analysis of small- or large (and intact) molecule biological analytes.
Primarily this support takes the form of a targeted "hyphenated" chromatographic or specfic mass spectrometry assay. However, the ACL also operates two qPCR instruments and also plays hosts to the plate-readers, spectrophotometers and gel-imagers that make up the Pharmacology department's shared instrument suite. Thus, regardless of whether use the instruments belonging to the ACL or the Pharmacology Dept., the ACL's staff can provide solutions to most small- and large molecule analysis problems -- including the construction of assays customized to your needs.
A Note about Metabolomics and MS-Imaging Experiments.
The ACL provides limited support for "metabolomics" and mass spectrometry imaging (MS-Imaging) experiments. The rapidly evolving nature of these fields makes it difficult to outline the ACLs capabilites in these areas, especially as the ACL is slowly improving those abilities. Clients seeking assistance with metabolomics or MS-imaging applications are encouraged to contact Jephte Akakpo (email@example.com).
The ACL services are structured so that we can customize them to the client's exact needs. Thus the ACL is can fully process (i.e. handle every step from extraction to data acquisition) a client samples or, alternately, run "ready to inject" samples on behalf of the client. KUMC-based clients can also request instrument-specific training which will permit them to run the instruments autonomously.Instrument Training.
The ACL encourages its clients operating our instruments themselves; as an academic Core facility it is part of our mission to hands-on, instrument training to those KUMC-based clients who request it, regardless of whether the client has an active project with the ACL or not.
Students and Post Docs should note that competency in chromatography and mass spectrometry are highly valued skills in both public and private science.
Client's working on an active project will be trained free of charge, those without a project will be subject to a surcharge for materials consumed during training.
Trained clients qualify for a discounted service-rates in addition to gaining the ability to book the instruments autonomously and access the instruments after-hours.
Clients seeking chromatography or mass spectrometry training should allow 3-5 full days for training.
To arrange for training please contact Jephte Akakpo (firstname.lastname@example.org).
Attribution & Co-authorship rights
Academic publications produced using data acquired by the ACL must at minimum acknowledge the ACL's assistance and the source of it's funding. We suggest that the following be added to the Acknowledgements section of your publication:
"Data presented in this work was collected with the assistance of the Analytical Core Laboratory (University of Kansas Medical Center, Kansas City, KS) which in turn was supported in part by grants fromthe National Institute of General Medical Sciences (P20GM103549 & P30GM118247 ) of the National Institutes of Health."
The Authors must alert the ACL to publication because we are required to report our scientific output in annual progress reports to the NIH and the KUMC School of Medicine.
The ACL will leave to the discretion of the primary author(s) the decision as to whether the scientific input provided by ACL staff merits their inclusion as Co-authors on any publication resulting from data collected within the ACL.