Publications

Click here for list of publications from PubMed.

Selected Publications

2010

• Bellon M, Baydoun H.H, Yao Y and Nicot C. HTLV-I Tax-dependent and independent events associated with Immortalization of Human Primary T-lymphocytes. Blood. 2010 Mar 25;115(12):2441-8. PMC2845900. Open access.
• Bai XT, Baydoun HH, Nicot C. HTLV-I p30: A versatile protein modulating virus replication and pathogenesis. Mol Aspects Med. 2010 Jun 4. [Epub ahead of print]
• Bai XT, Baydoun HH, Nicot C. HTLV-I p30: A versatile protein modulating virus replication and pathogenesis. Mol Aspects Med. 2010 Jun 4. [Epub ahead of print]

2009

• Fukumoto R, Andresen V, Bialuk I, Cecchinato V, Walser JC, Valeri VW, Nauroth JM, Gessain A, Nicot C, Franchini G. In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein. Blood. 2009 Apr 16;113(16):3726-34. PMC2670790. Open access.
• Baydoun HH, Bellon M, Nicot C. HTLV-I Yin and Yang:Rex and p30 master regulators of viral mRNA trafficking. AIDS Reviews. 2008 Oct-Dec; 10(4):195-204. PMC2666328. Open access.
• Bellon M, Lepelletier Y, Hermine O, Nicot C. Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia. Blood. 2009 May 14;113(20): 4914-7. PMC2686141. Open access.
• Taylor JM, Ghorbel S, Nicot C. Genome wide analysis of human genes transcriptionally and post-transcriptionally regulated by the HTLV-I protein p30. BMC Genomics. 2009 Jul 14;10:311.  PMC2723137. Open access.
• Bellon M, Baydoun HH, Yao Y, Nicot C. HTLV-I Tax-dependent and independent events associated with Immortalization of Human Primary T-lymphocytes. Blood. (Accepted with revisions.)
• Taylor JM, Brown M, Nejmeddine M, Kim KJ, Ratner L, Lairmore M, Nicot C. A novel role for IL2R-Jak signaling in retrovirus transmission. J Virol. 2009 Nov 83(22). Open access.

2008

• Baydoun HH, Bellon M, Nicot C. HTLV-1 Yin and Yang: Rex and p30 Master Regulators of Viral mRNA Trafficking. AIDS Rev. 2008 Oct-Dec;10(4):195-204 .Open access.
• Fukumoto R, Andresen V, Bialuk I, Cecchinato V, Walser JC, Valeri VW, Nauroth JM, Gessain A, Nicot C, Franchini G. In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein. Blood. 2008 Sep 12. Open access.

• Taylor JM, Nicot C. HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. Apoptosis. 2008 Jun;13(6):733-47. Open access
• Bellon M, Nicot C. Central role of PI3K in transcriptional activation of hTERT in HTLV-I infected cells. Blood. 2008 May 29. Open access
• Bellon M, Nicot C. Regulation of telomerase and telomeres: human tumor viruses take control. J Natl Cancer Inst. 2008 Jan 16;100(2):98-108. Epub 2008 Jan 8.Open access.
• Sinha-Datta U, Taylor JM, Brown M, Nicot C. Celecoxib disrupts the canonical apoptotic network in HTLV-I cells through activation of Bax and inhibition of PKB/Akt. Apoptosis. 2008 Jan;13(1):33-40.Open access.

2007

• Bellon M, Nicot C. Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia. : Cancer Genomics Proteomics. 2007 Jan-Feb;4(1):21-5. Open access.
• Datta A, Nicot C. Telomere attrition induces a DNA double-strand break damage signal that reactivates p53 transcription in HTLV-I leukemic cells. Oncogene. 2007 Aug 20. Open access.
• Lacoste V, Nicot C, Gessain A, Valensi F, Gabarre J, Matta H, Chaudhary PM, Mahieux R. In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle. Br J Haematol. 2007 Aug;138(4):487-501. Open access
• Sinha-Datta U, Datta A, Ghorbel S, Dodon MD, Nicot C. Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication. J Biol Chem. 2007 May 11;282(19):14608-15. Open access
• Brown M, Bellon M, Nicot C. Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1. Blood. 2007 Feb 15;109(4):1653-9. Open access
• Fukumoto R, Dundr M, Nicot C, Adams A, Valeri VW, Samelson LE, Franchini G. Inhibition of TCR Signal Transduction and Viral Expression by the Linker for Activation of T Cells-Interacting p12I Protein of HTLV-1.  J Virol. 2007 Jun 20. Open access

2006

• Ghorbel S, Sinha-Datta U, Dundr M, Brown M, Franchini G, Nicot C. Human T-cell leukemia virus type I p30 nuclear/nucleolar retention is mediated through interactions with RNA and a constituent of the 60 S ribosomal subunit.  J Biol Chem. 2006 Dec 1;281(48):37150-8. Open access
• Bellon M, Datta A, Brown M, Pouliquen JF, Couppie P, Kazanji M, Nicot C. Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.  Int J Cancer. 2006 Nov 1;119(9):2090-7. Open access
• Datta A, Sinha-Datta U, Dhillon NK, Buch S, Nicot C. The HTLV-I p30 interferes with TLR4 signaling and modulates the release of pro- and anti- inflammatory cytokines from human macrophages.  J Biol Chem. 2006 Aug 18;281(33):23414-24.Open access
• Datta A, Bellon M, Sinha-Datta U, Bazarbachi A, Lepelletier Y, Canioni D, Waldmann TA, Hermine O, Nicot C.
  Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent
  senescence. Blood. 2006 Aug 1;108(3):1021-9. Epub 2006 Mar 28. Open access

2005

• Nicot C, Harrod RL, Ciminale V, Franchini G.
  Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions. Oncogene. 2005 Sep 5;24(39):6026-34. Open access
• Nicot C. Current views in HTLV-I-associated adult T-cell leukemia/lymphoma. Am J Hematol. 2005 Mar;78(3):232-9. Open access

2004

• Nicot C, Dundr M, Johnson JM, Fullen JR, Alonzo N, Fukumoto R, Princler GL, Derse D, Misteli T, Franchini G.
  HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med. 2004 Feb;10(2):197-201. Open access
• Sinha-Datta U, Horikawa I, Michishita E, Datta A, Sigler-Nicot JC, Brown M, Kazanji M, Barrett JC, Nicot C.
  Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood. 2004 Oct 15;104(8):2523-31. Open access