Marco Blanchette, PhD

Assistant Investigator, Stowers Institute for Medical Research
Assistant Professor of Pathology and Laboratory Medicine, Division of Cancer & Developmental Biology
Ph.D.: Université de Sherbrooke, Sherbrooke, Québec, Canada, 2000
Postdoctoral: University of California, Berkeley, 2000-2006


Publications: Click here

Blanchette Lab web site

Ph.D. students are welcome. Contact me for more info.

One surprising result of the recent sequencing of the human genome was that the number of predicted genes is significantly lower than had been anticipated. Alternative pre-mRNA splicing is a powerful, important, and prevalent strategy that higher eukaryotes have developed to increase the number of different proteins encoded by their genome. Moreover, alternative splicing plays a major role in gene regulation, is frequently developmentally or tissue-specifically regulated, and can generate distinct protein isoforms with different functions. Even today, the molecular mechanisms governing alternative splicing are poorly understood, but the key regulatory proteins, as well as the mechanisms identified thus far, are well conserved between metazoan species. Hence, the use of the fruit fly Drosophila melanogaster, with its small and well-annotated genome, continues to be a powerful system with which to decipher the mechanisms involved in alternative pre-mRNA splicing. My laboratory is interested in understanding detailed mechanisms controlling alternative splicing. Future efforts concentrate on three major areas: 1) identification of genes and splicing events regulated by specific splicing factors, 2) identification of the protein factors and RNA sequence elements controlling specific alternative splicing events, and 3) characterization of the detailed molecular mechanisms controlling specific alternative splicing events.

Blanchette Lab Members

Todd Bradley, Predoctoral Researchertbr@stowers-institute.org

Nazmul Haque, Postdoctoral Research Associatenha@stowers-institute.org

Scot Harms, Research Technician IIsha@stowers-institute.org

Nehemiah Alvarez, Research Technician Inal@stowers-institute.org

David Rebecchi, Research Technician Idrr@stowers-institute.org

 

Last modified: Feb 28, 2013

Contact

Marco Blanchette, PhD
Assistant Investigator, Stowers Institute for Medical Research
Assistant Professor of Pathology and Laboratory Medicine, Division of Cancer & Developmental Biology

Stowers Institute for Medical Research
1000 East 50th St.
Kansas City, MO 64110

P: 816-926-4071 / C: 816-726-8419
F: 816-926-2018
mab@stowers.org

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