Jeremy Chien, PhD

Assistant Professor, Cancer Biology
Assistant Director, Translational Genomics, University of Kansas Cancer Center
Ph.D.: Reproductive Physiology, University of Kansas Medical Center, Kansas City, Kan.
Postdoctoral: Tumor Biology, Mayo Clinic, Rochester, Minn.

Integrated Cancer Genomics Lab website

Research Description

The primary goal of my research program is to understand the genetic basis for ovarian carcinogenesis. To achieve this goal, I use two complementary genetic and functional approaches: the genetic approaches are used to identify candidate disease genes by next-generation sequencing of cancer genomes; and the functional approaches are used to characterize molecular mechanisms of candidate disease genes in ovarian carcinogenesis. My long-term goals are to advance ovarian cancer biology through integrated cancer genomics, functional genomics, and proteomics, and to translate these advances into clinical applications in early detection, diagnosis, prognosis, and treatment of ovarian cancer.

I am applying next-generation sequencing technologies, functional genomics, and proteomics to characterize alterations in cancer genomes and biological pathways associated with critical steps in ovarian carcinogenesis; namely, malignant transformation, metastasis, and resistance to chemotherapy. Using mouse models, I am defining the in vivo role of tumor suppressor genes and oncogenes in tubal carcinogenesis. In addition, I am applying next generation sequencing technologies to develop genome-based biomarkers for the detection and diagnosis of ovarian cancer. Ultimately, I plan to employ various expertise acquired through previous training in reproductive physiology, cancer genetics, and tumor biology to integrate system-level understanding with molecular-level approaches to understand ovarian carcinogenesis.

Publications:

1. He X, Khurana A, Maguire JL, Chien J, Shridhar V. HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation. Int J Cancer. 2012 Mar 1; 130(5):1029-35. Epub 2011 Apr 25.
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2. Fan JB, Chen J, April CS, Fisher JS, Klotzle B, Bibikova M, Kaper F, Ronaghi M, Linnarsson S, Ota T, Chien J, Laurent LC, Nisperos SV, Chen GY, Zhong JF. Highly parallel genome-wide expression analysis of single mammalian cells. PLoS ONE. 2012; 7(2):e30794.
3. Goode EL, Chenevix-Trench G, Hartmann LC, Fridley BL, Kalli KR, Vierkant RA, Larson MC, White KL, Keeney GL, Oberg TN, Cunningham JM, Beesley J, Johnatty SE, Chen X, Goodman KE, Armasu SM, Rider DN, Sicotte H, Schmidt MM, Elliott EA, Hogdall E, Kjaer SK, Assessment of hepatocyte growth factor in ovarian cancer mortality. Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1638-48. Epub 2011 Jul 01.
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4. Li Y, Chien J, Smith DI, Ma J. FusionHunter: identifying fusion transcripts in cancer using paired-end RNA-seq. Bioinformatics. 2011 Jun 15; 27(12):1708-10. Epub 2011 May 05.
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5. Khurana A, Liu P, Mellone P, Lorenzon L, Vincenzi B, Datta K, Yang B, Linhardt RJ, Lingle W, Chien J, Baldi A, Shridhar V. HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells. Cancer Res. 2011 Mar 15; 71(6):2152-61. Epub 2011 Jan 25.
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