Adam J. Krieg, PhD

Assistant Professor, Department of Obstetrics and Gynecology

Ph.D., University of Illinois, Urbana-Champaign, 2003
Postdoctoral, Stanford University, 2003-2010



akrieg@kumc.edu

The primary focus of our laboratory is the study of the transcriptional mechanisms activated in response to reduced cellular oxygen, or hypoxia.  A significant proportion of hypoxic gene expression is mediated by the Hypoxia Inducible Factors (HIFs), transcription factors that induce the expression of genes important for anaerobic metabolism, blood vessel recruitment, cell motility, and stem cell maintenance.  Of particular interest is the hypoxic expression of several histone demethylase genes by the HIFs.  Since histone demethylases affect gene expression by modifying the chromatin of target genes, hypoxic regulation of this phenomenon creates an intriguing link between cellular microenvironment, HIF activation, and downstream cascades of gene expression that could prolong the initial cellular response to hypoxia.  We are currently studying the functional consequences of hypoxic histone demethylase expression in the context of normal cell biology and in disease states ranging from cancer to intrauterine growth restriction.

Last modified: Jun 20, 2013

Adam J. Krieg, PhD

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Adam J. Krieg, PhD
Assistant Professor, Department of Obstetrics and Gynecology

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