M.A. Karim Rumi, MBBS, Ph.D.

Research Associate Professor
Division of Cancer and Developmental Biology, Department of Pathology and Laboratory Medicine

Ph.D., Shimane Medical University, Izumo-City, Japan, 2004
Postdoctoral Fellowship, MD Anderson Cancer Center, Houston, TX, 2006-2007
Postdoctoral Fellowship, Univesity of Kansas Medical Center, 2007-2008

Publications: Click here

Research Focus

Transcriptional regulation of trophoblast differentiation

Research Interest:

Our laboratory is interested in the regulation of cell differentiation, especially as related to trophoblast stem cells, and signaling pathways controlling their developmental fate. We are also interested in species-specific reproductive adaptations to physiological stressors and signaling events involved in the establishment and maintenance of pregnancy, including investigations on the prolactin gene family, intrauterine inflammatory and immune cells, uterine vasculature, decidual cells and the invasive trophoblast cell lineage.

Selected Recent Publications:

Asanoma K, Kubota K, Chakraborty D, Renaud SJ, Wake N, Fukushima K, Soares MJ, Rumi MA. SATB proteins regulate trophoblast stem cell renewal and differentiation. J Biol Chem, 2012; 287: 2257-68.

Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. Fosl1 is integral to establishing the maternal-fetal interface. Mol and Cell Biol. 2011; 31: 4801-13.

Chakraborty D, Rumi MA, Konno T, Soares MJ. Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions. Proc Natl Acad Sci USA 2011; 108: 16295-300.

Asanoma K, Rumi MA, Kent LN, Chakraborty D, Renaud SJ, Wake N, Lee DS, Kubota K, Soares MJ. FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage. Dev Biol. 2011; 351: 110-9.

Konno T, Rempel LA, Rumi MA, Graham AR, Asanoma K, Renaud SJ, Soares MJ. Chromosome-substituted rat strains provide insights into the genetics of placentation. Physiol Genomics. 2011; 43: 930-41.

Last modified: Mar 07, 2016


M.A. Karim Rumi, MBBS, Ph.D.
Research Associate Professor

Laboratory: 3088 Hemenway Building
(913) 588-5690
Office: 3056 Hemenway Building

P: (913) 588-5690
F: (913) 588-8287