Ling Lu, PhD

Assistant Professor
PhD: Infectious Diseases, Sun Yat-sen University of Medical Sciences, Guangzhou, China

Basic Science Interests:

Our lab focus: Study HCV molecular epidemiology and genetics, determine the full-length genomic sequences for the majority of HCV subtypes that still have not been completely sequenced, use the newly determined sequences to assemble a complete HCV reference panel and establish novel cell culture models.

Selected publications:

• Lu, L., Nakano, T., Orito, E., Mizokam, M. and Robertson, B. H. (2001). Evaluation of accumulation of hepatitis C virus mutations in a chronically infected chimpanzee: comparison of the core, E1, HVR1, and NS5b regions. J Virol 75:3004-3009.
• Nakano, T., Lu, L., Hu, X., Mizokami, M., Orito, E., Shapiro, C., Hadler, S. and Robertson, B. H. (2001). Characterization of hepatitis B virus genotypes among Yucpa Indians in Venezuela. J Gen Virol 82:359-365.
• Lu, L., Ng, M. H., Zhou, B., Luo, H., Nakano, T., Robertson, B. H. and Im S. W. (2001). Detection and genotyping of GBV-C/HGV variants in China. Virus Res 73:131-144.
• Quarleri, J. F., Bussy, M. V., Mathet, V. L., Ruiz V., Iacono, R., Lu, L.,Robertson, B.H. and Oubina, J. R. (2003). In vitro detection of dissimilar amounts of hepatitis C virus (HCV) subtype-specific RNA genomes in mixes prepared from sera of persons infected with a single HCV genotype. J Clin Microbiol 41:2727-2733.
• Lu, L., Ching, K. Z., de Paula, V. S., Nakano, T., Siegl, G., Weitz, M. and Robertson, B. H. (2004). Characterization of the complete genome sequence of genotype II hepatitis A virus (CF53/Berne isolate). J Gen Virol  85:2943-2952.
• dePaula, V. S., Lu, L., Niel, C., Gaspar, A.M.C. and Robertson, B.H. (2004). Genetic analysis of hepatitis A virus isolates from Brazil. J Med Virol73:378-383.
• Lu, L.,  Drobeniuc, J., Kobylnikov, N., Usmanov, R.K., Robertson, B.H., Favorov, M.O. and Margolis, H.S. (2004). Complete sequence of a Kyrgyzstan swine hepatitis E Virus (HEV) isolated from a piglet thought to be experimentally infected with human HEV. J Med Virol 74:556-562.
• Nakano, T., Lu, L., Liu, P. and Pybus., O.G. (2004). Viral gene sequences reveal the variable history of hepatitis C virus infection among countries. J Infect Dis 190:1098-1108.
• Lu, L., Nakano, T., He, Y., Fu, Y., Hagedorn, C.H. and Robertson, B. H. (2005). Hepatitis C Virus genotype distribution in China: Predominance of closely related subtype 1b isolates and existence of new genotype 6 variants.  J Med Virol 75:538-549. (corresponding author)
• Lu, L., Nakano, T., Robertson, B.H. and Hagedorn, C.H. (2005). A refined long RT-PCR technique to amplify complete viral RNA genome sequences from clinical samples: application to a novel hepatitis C virus variant of genotype 6. J Virol Meth 126:139-148. (corresponding author)
• Lu, L., Li, C. and Hagedorn, C.H. (2006). Phylogenetic analysis of global hepatitis E virus sequences: Genetic diversity, subtypes and zoonosis.Rev Med Virol 16:5-36. (corresponding author)
• Nakano, T., Lu, L, He, Y., Fu, Y., Robertson, B.H. and Pybus, O.G. (2006). The population genetic history of hepatits C virus 1b infection in China. J Gen Virol 87:73-82. (equally contributed first author)
• Lu, L., Nakano, T., Li, C., Fu, Y., Miller, S., Kuiken, C. Robertson, B.H. and Hagedorn., C.H. (2006). Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel yet unassigned subtype within genotype 6. J Gen Virol 87:629-634. (corresponding author)
• Nainan, O., Lu, L., Gao, F., Emory, M., Robertson, B.H. and Margolis, H. (2006). Selective transmission of HCV genotypes and quasispecies in humans and chimpanzees. J Gen Virol 87:83-91.
• Li, C., Fu, Y., Lu, L. and Hagedorn, C. H. (2006). Complete genome sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection. J Med Virol 78:1061-1069. (corresponding author)
• Lu, L., Li, C., Fu, Y., Thaikruea, L., Thongswat, S., Maneekarn, N., Apichartpiyakul, C., Hotta, H., Okamoto, H., Netski, D., Pybus, O. G., Murphy, D., Hagedorn, C. H. and Nelson, K. E. (2007). Complete genomes for hepatitis C virus subtypes 6f, 6i, 6j and 6m: viral genetic diversity among Thai blood donors and infected spouses. J Gen Virol88:1505-1518. (corresponding author)
• Lu, L., Li, C., Fu, Y., Gao, F., Pybus, O. G., Abe, K., Okamoto, H., Hagedorn, C. H. and Murphy, D. (2007). Complete genomes of hepatitis C virus (HCV) subtypes 6c, 6l, 6o, 6p and 6q: completion of a full panel of genomes for HCV genotype 6. J Gen Virol 88:1519-1525. (corresponding author)
• Zhao, S. M., Jiang, T. L., Gao, F. X., Lu, L., Zheng, H. Q., Hu, J., Fan, Y. H.,Li, B., Xiao, R. R. and Yury, K. (2007). Analysis of true voluntary blood donors with anti-HCV prevalence and implications for donor management in Chongqing, China. Transfus Med 17:210-211.
• Lu, L., Murphy, D., Li, C., Liu, S., Xia, X., Pham, P. H., Jin, Y., Hagedorn, C. H. and Abe, K. (2008). Complete genomes of three subtype 6t isolates and analysis of many novel hepatitis C virus variants within genotype 6. J Gen Virol 89:444-452. (corresponding author)
• Lu, L., Tastunori, N., Li C., Gao, F. and Robertson, B. H. (2008). Selection of HCV strains and evolution of HVR1 variants in a chimpanzee chronically infected with HCV-1 over 12 years. Hepatol Res 38:704-16. (corresponding author)
• Xia, X, Lu, L, Tee, K. K., Zhao, W., Wu, J., Yu, J., Li, X., Lin, Y., Mukhtar, M. M., Hagedorn, C. H. and Takebe, Y. (2008). The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China. J Med Virol  80:1142-1152. (equally contributed first author)
• Xia, X., Zhao, W., Tee, K. K., Feng, Y., Takebe, Y., Li, Q., Pybus, O. G. andLu, L. (2008). Complete genome sequencing and phylogenetic analysis of HCV isolates from China reveals a new subtype, designated 6u. J Med Virol 80:1740-1746. (corresponding author)
• Zhao SM, Jiang TL, Li RQ, Gao FX, Lu L, Zheng HQ, Hu J, Fan YH, Li B,Xiao RQ and Yury K. (2008). HCV infection in voluntary donors and its influence on recruitment of donors in Chongqing area. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:676-680.
• Li C, Zhang X, Lu L and Murphy D. (2009). Entire genome sequences of two new HCV subtypes, 6r and 6s, and characterization of unique HVR1 variation patterns within genotype 6. J Viral Hepatitis 16:406-417. (corresponding author)
• Pybus, O. G., Barnes E., Taggart, R., Lemey, P., Markov, P., Rasachak, B., Syhavong, B., Rattanaphone, P., Sheridan, I., Humphreys, I. S., Lu, L., Newton, P. and Klenerman, P.  (2009). The Genetic History Of The Hepatitis C Virus In East Asia. J Virol  83:1071-1082.
• Wang, Y., Xia, X., Li, C., Maneekarn, N., Xia, W., Zhao, W., Feng, Y., Kung, H. F., Fu, Y. and Lu, L. (2009). A new HCV genotype 6 subtype designated 6v was confirmed with three complete genome sequences. J Clin Virol44:195-199. (corresponding author)
• Li, C., Lu, L., Wu, X., Wang, C., Bennett, P., Lu, T. & Murphy, D. (2009). Complete genomic sequences for HCV subtypes 4b, 4c, 4d, 4g, 4k, 4l, 4m, 4n, 4o, 4p, 4q, 4r and 4t. J Gen Virol 90: 1820-1826. (corresponding author)
• Fu, Y., Xia, W., Wang, Y., Tian, L., Pybus, O. G., Lu, L. & Nelson, K. (2010). Decreased anti-HCV seraprevalence among 559,890 first-time volunteer donors in 2004-2007 reflects the success in transition of blood donor recruitment models in Guangzhou, China. Transfusion 50: 1505-1511. (corresponding author)
• Fu, Y., Xia, W., Wang, Y., Pybus, O. G., Lu, L. & Nelson, K. (2011). New trends of HCV infection in China revealed by genetic analysis of first-time volunteer blood donors. J Viral Hepat 18: 42-52. (corresponding author)
• Liu, S, Nelson C.A., Xiao, L., Lu, L., Seth, P.P., Davis, D.R., Hagedorn, C.H. (2011). Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase. Antiviral Res 89: 54-63.
• Schwarz, K.B., Roy, A., Wang, C., Li, C., Lu, L., Torbenson, M., Hagedorn, C.H. (2011). Phenotypic and genotypic differences between a child with vertically acquired severe hepatitis C liver disease and his mother. J Pediatric Gastroenterol & Nutrition. In press.