Christophe P Nicot, Ph.D.

Professor; Director, Center for Viral Oncology

Professor, University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, 2009-present
Associate Professor, University of Kansas Medical Center, Department of Microbiology, Molecular Genetics & Immunology and Department of Pathology and Laboratory Medicine, Kansas City, KS, 2006-2009
Assistant Professor, University of Kansas Medical Center, Department of Microbiology, Molecular Genetics & Immunology, Kansas City, KS, 2003-2006
Staff Scientist, National Cancer Institute, Division of Basic Sciences, 2000-2003
Visiting Fellow, National Cancer Institute, Division of Basic Sciences, 1998-2000
Research Associate, Uniformed Services University of the Health Sciences, Dept. of Microbiology and Immunology, 1996-1998
Research Associate, Case Western Reserve University, Dept. of Infectious Diseases, 1995-1996
Ph.D., University of Bordeaux, France, 1995


Publications: Click here

 The oncogenic human retrovirus HTLV-I is the etiological agent of an aggressive and fatal T-cell leukemia/lymphoma (ATL) disease. ATL is associated with a poor clinical prognosis and treatment of patients using conventional chemotherapy has limited benefit given that HTLV-I cells are resistant to conventional anti-cancer, apoptosis-inducing agents. In addition to ATLL, HTLV-I is also the etiological agent of an inflammatory neuro-degenerative disorder called Tropical Spastic Paraparesis/ HTLV-I-Associated Myelopathy (TSP/HAM). My laboratory studies early and late molecular events associated with cellular transformation and leukemogenesis. We are especially interested in genome instability, telomerase reactivation, RNA export and signaling pathways involved in T-cell transformation and/or virus replication. We also study new therapeutic approaches for treatment of ATL.

Nicot Lab web site.

Selected Publications

2016

2015

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    Last modified: Sep 29, 2016

    Contact

    Christophe P Nicot, Ph.D.
    Professor; Director, Center for Viral Oncology

    Pathology & Laboratory Medicine
    3901 Rainbow Blvd
    Kansas City, KS 66160

    P: 913-588-6724/ Lab:913-588-7050
    cnicot@kumc.edu

    ID=x10503