Clinical Research

Research TeamKU OTOLARYNGOLOGY RESEARCH TEAM (left to right): Dr. Kevin Sykes, Mrs. Kendra Ford, and Dr. Chelsea Hamill

The Department of Otolaryngology is committed to providing our patients access to the most advanced therapies available by supporting clinical research. Kevin Sykes, PhD, MPH leads this division of the department as the Director of Clinical Research and has been in this role since 2005. This is a team effort and critical to our success is the experience and effort of our Clinical Research Nurse, Kendra Ford, MSN, RN, CCRC. Since 2010, we have offered full-time or part-time research assistant positions for students interested in medical school. In 2016, we began a Research Fellowship, currently held by Chelsea Hamill, MD, that provides recent medical school graduates with a year of research experience.

As one of the leading neurotology sites in the United States for hearing and balance related research and clinical trials, we attract patients from across the country interested in advancing science and receiving care that is only offered at select institutions. This research includes a first of its kind Phase I clinical trial testing the safety and tolerability of an inner ear infusion of CGF166, a gene therapy aiming to treat severe to profound hearing loss. We also routinely offer clinical trials in head and neck oncology, pediatric otolaryngology, and rhinology. We are currently enrolling in the clinical trials listed below and one of our clinical research team members would be happy to help you learn more about these trials (entresearch@kumc.edu) or you can register to be contacted for future research projects on the KUMC website for volunteers.

In addition to our prospective clinical trials, the department continues to review critically the care we provide to our patients. Retrospective studies, including several multicenter projects, serve to analyze the patterns and outcomes for patients with the aim of improving the evidence base for our treatment options and generating hypotheses for future research. Utilizing large national administrative datasets allows for health services research that examines similar questions on a national scale looking for trends and opportunities for improvements in care related to otolaryngology as it is performed in the United States.

The department's commitment of resources to clinical and basic science research promises to keep the University of Kansas at the forefront of advancement for the specialty. 

Current Research in the Department of Otolaryngology-Head and Neck Surgery


Otology

A three-part, multicenter, open label, single dose study to assess the safety, tolerability, and efficacy of intra-labyrinthine (IL) CGF166 in patients with severe hearing loss.
Principal Investigator: Hinrich Staecker, MD, PhD  

Long-term Safety and Efficacy Follow-up Study of CGF166-Treated Patients    
Principal Investigator: Hinrich Staecker, MD, PhD  

AM-101 in the Post-Acute Treatment of Peripheral Tinnitus 1 (AMPACT1) - an Open-Label Extension to the TACTT2 Study.
Principal Investigator: Hinrich Staecker, MD, PhD   

The HEARRING Registry, Quality of Life Assessment, and Genetic Sub-Studies - A Collaborative Effort for Global Outcomes with MED-EL Hearing Implants    
Principal Investigator: Hinrich Staecker, MD, PhD   

A Prospective, Randomized, Double Blind, Placebo-Controlled, Multicenter, Phase 3 Efficacy and Safety Study of OTO-104 Given as a Single Intratympanic Injection in Subjects with Unilateral Meniere's Disease            
Principal Investigator: Hinrich Staecker, MD, PhD   


General Otolaryngology

Prospective, Non-Randomized Registry for the Evaluation of Sialendoscopy in the Diagnosis and Management of Sialolithiasis and Chronic Sialadenitis Principal Investigator: Christopher Larsen, MD  

Monitoring Juvenile Onset Recurrent Respiratory Papillomatosis - A Multicenter CDC Sponsored Registry            
Principal Investigator: Daniel Bruegger, MD  

AAO-HNS Simulation as a Tool for Education Innovation: The Simtube Project            
Principal Investigator: Keith Sale, MD    


Head and Neck Oncology

Phase II Randomized Trial of Transoral Surgical Resection Followed by Low-Dose or Standard-Dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer            
Principal Investigator: Lisa Shnayder, MD  

Patient Education and Satisfaction in Free Flap Surgery            
Principal Investigator: Kiran Kakarala, MD         

Last modified: Aug 29, 2016
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