Jinxi Wang, M.D., Ph.D.
The Harrington Laboratory for Molecular Orthopedics, directed by Jinxi Wang, MD, PhD, was established in 2005. The name of this laboratory is in honor of Dr. Paul. R. Harrington's outstanding contributions to orthopedic research and in accordance with his wishes in the gift letter of the Mary Alice & Paul R. Harrington, MD, Distinguished Professorship Endowment. To learn more about Dr. Harrington (click here)
The Harrington Laboratory occupies ~2100 sq ft of laboratory and office space, with a meeting room equipped for research and educational presentations. The laboratory is well equipped for research in morphology (e.g., histochemistry, immunohistochemistry, and immunocytochemistry), biochemistry (e.g., protein purification and quantification), cellular and molecular biology (e.g., cell culture and DNA transfection, RNAi-mediated gene silencing, RNA and DNA isolation, conventional PCR and qPCR, preparation of plasmid constructs, ChIP assay, and generation of transgenic mice). These facilities and technologies are dedicated to the study of bone and cartilage biology as well as pathogenesis of specific skeletal diseases such as osteonecrosis and osteoarthritis. Currently, research in this laboratory is focused on the following areas: (1) the regulatory mechanisms of osteoblast differentiation and bone regeneration, (2) pathogenetic mechanisms and novel therapeutics for osteoarthritis, and (3) molecular regulation of chondrocyte function and articular cartilage regeneration.