Women's Reproductive Health Research
Reveal 1 - Kevin Ault, MD
Treatment for Cervical HSIL
Double blind, placebo-controlled phase 3 study of VGX-3100 delivered intramuscularly follow by electroporation for the treatment of HPV16 and/or HPV18 related high grade squamous intraepithelial lesions(HSIL) of the cervix
HPV-201 - Kevin Ault, MD
A Phase 2,randomize, efficacy study of VGX- delivered intramuscularly followed by electroporation alone or in combination with imiquimod, for the treatment of HPV-16 and/or HPV-18 related to high grade squamous intraepithelial lesion(HSIL) of the vulva
Reproductive Endocrinology and Infertility
Mitochondrial RNA defense pathways in the oocyte - Lane Christenson, PhD
Because aging in women is highly associated with reduced fertility, in this proposal we will examine how increased abundance of toxic RNA species is related to mitochondrial function and oocyte quality. We will examine the role of an unexplored post-transcriptional mechanism of RNA regulation, the mitochondrial RNA defense pathway, in oocytes. This research could lead to a breakthrough in our understanding of the process of aging, and how it impacts oocyte quality and fertility in women.
Funding Dates - 04/01/2018 03/31/2023
Role of Follicular Fluid Exosomes on Induction of Ovarian/Fallopian Carcinogenesis - Lane Christenson, PhD
This grant will explore the initial carcinogenic events of ovarian / oviductal cancer and its positive association with the number of times a woman ovulates (i.e., releases follicular fluid) during her lifespan. Follicular fluid is known to induce changes associated with tumorgenesis in oviductal epithelial cells, yet the factors responsible remain unknown. Recently, small membrane vesicles known as exosomes were identified in follicular fluid. We are exploring their role in the carcinogenesis of oviductal epithelial cells in vitro and in vivo.
Trophoblast Progenitors and Pregnancy - Soumen Paul, PhD
Miscarriage causes termination of 15-20% of implantation-confirmed pregnancies. The majority of miscarriages occur during the first trimester of pregnancy. The defective development of trophoblast cell lineage, which assures embryo implantation and placentation, is one of the leading causes for early pregnancy loss. The goal of this study is to identify the molecular mechanisms involved in trophoblast cell lineage development and determine the association with early pregnancy loss.
Epigentic changes to oocyte development in poly cystic syndrome - Katherine Roby, PhD
The aim of this study is to determine how epigenetic factors contribute to abnormal folliculogenesis in polycystic ovarian syndrome(PCOS) and how environmental factors may play a role in PCOS.
Maternal Fetal Medicine
Chronic Hypertension and Pregnant (CHAP) - Marc Parrish, DO
An NIH grant through UAB, randomized treatment of women with mild Chronic Hypertension(<160/105) to be treated early or ACOG standard treatment. It is to test the effectiveness reducing frequency of key adverse maternal and newborn outcomes associated with cHTN including: 1.fetal or neonatal death 2. Preeclampsia with severe features 3. Placenta abruption or indicated preterm birth< 35 weeks 4. SGA (birth wt. < 10 percentile)
Arabin RCT trial - Carl Weiner, MD
It is a study to show how effective a pessary would be in women with short cervix opposed to surgical placement of a cerclage.
The pessary would be placed in an office visit opposed to surgery and operational cost.
Treatment of Twin to Twin Transfusion Syndrome - Carl Weiner, MD
Twin-to-twin transfusion syndrome is a disorder affecting monozygotic twins. Historically theses pregnancies ended prior to 24 weeks, secondary to massive hydramnios and spontaneous delivery. Selective laser ablation of anastomotic vessels to improved outcomes with an almost abolishment of neurologic sequelae.
Velo Bio - Marc Parrish, DO
Study of Efficacy and Safety of DigiFab in Antepartum Subjects with severe Preeclampsia
A randomized, double blind, placebo-controlled study for the Efficacy and Safety of DigiFab for the prevention of intraventricular hemorrhage, necrotizing enterocolitis, or death. Currently there is not a treatment for severe preeclampsia besides delivery.
SQNM-T21-107 - Carl Weiner, MD
Collection of Whole Blood Specimens from pregnant women at increased for fetal chromosomal abnormality for use in development of a noninvasive prenatal test in the detection on the relative quantity of chromosomal material in circulating cell-free DNA extracted from maternal plasma.
KU Pregnancy Biobank - Carl Weiner, MD
Study of biomarkers to predict and treat conditions