In-Young Choi, Ph.D.

Associate Professor


Biographical sketch

In-Young Choi, Ph.D. is an associate professor in the Department of Neurology at the University of Kansas Medical Center. She is also a faculty member with the Department of Molecular & Integrative Physiology and Hoglund Brain Imaging Center, and is affiliated with the Bioengineering Program at the University of Kansas. Dr. Choi received her Ph.D. in Biophysical Sciences and Medical Physics from the University of Minnesota and was trained in magnetic resonance imaging / spectroscopy techniques and neurobiology at the Center for Magnetic Resonance Research at the University of Minnesota. Prior to taking a position at KUMC in 2005, she was a Senior Research Scientist and Section Leader for Magnetic Resonance Spectroscopy at the Center for Advanced Brain Imaging and Department of Medical Physics at the Nathan Kline Institute in New York. Dr. Choi is a member of the American Academy of Neurology, American Diabetes Association, International Society for Neurochemistry, International Society for Magnetic Resonance in Medicine, International Society of Cerebral Blood Flow and Metabolism, and Society for Neuroscience.

Research summary

Dr. Choi's research focuses largely on the identification of quantitative, objective biomarkers of the pathologic mechanisms underlying disease status and progression in a variety of neurological conditions to characterize metabolic, morphological and functional pathophysiology of the disease, and to guide and accelerate the development of new treatment strategies.  Dr. Choi works on the development of advanced noninvasive in vivo magnetic resonance imaging and spectroscopy techniques to investigate changes resulting from a range of conditions including diabetes, cancers, neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, stroke, and Alzheimer disease. Dr. Choi's interdisciplinary translational research encompasses biomedical imaging, neurology, neurobiology, and neurochemistry in both clinical and pre-clinical studies. Dr. Choi's expertise lead her to serve as the volume editor of a Handbook Series Advances in Neurobiology titled "Neural Metabolism In Vivo," which consists of 42 chapters covering the entire fields of in vivo neurochemistry and neurobiology related to neural metabolism and function using various neuroscience tools and methods.  Quantitative assessment of region-specific alterations of neurotransmitters and cerebral antioxidants (e.g., vitamin C and glutathione) in aging, neurodegeneration and neurological disorders are examples of the clinical application of Dr. Choi's novel neuroimaging techniques. 

Contact Information

Email: ichoi@kumc.edu
Phone: 913-588-0174
Fax: 913-588-9071

Mailing Address:
Hoglund Brain Imaging Center
3901 Rainbow Blvd., Mail Stop 1052
University of Kansas Medical Center
Kansas City, KS 66160

Selected Publications

I.-Y. Choi, I. Tkac, K. Ugurbil, R. Gruetter, Noninvasive measurements of [1-13C]glycogen concentrations and metabolism in rat brain in vivo.  J Neurochem 73:1300 - 1308 (1999) PMID: 10461925

J. Pfeuffer, I. Tkac, I.-Y. Choi, H. Merkle, K. Ugurbil, M. Garwood, R. Gruetter, Localized in vivo 1H NMR Detection of Neurotransmitter Labeling in Rat Brain during Infusion of [1-13C] D-Glucose.  Magn Reson Med 41:1077 - 1083 (1999) PMID: 10371437

Tkac, Z. Starcuk, I.-Y. Choi, R Gruetter, In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time.  Magn Reson Med 41:649 - 656 (1999) PMID: 10332839

I.-Y. Choi, I. Tkac, R. Gruetter, Single-shot, three-dimensional "non-echo" localization method for in vivo NMR spectroscopy.  Magn Reson Med 44:387 - 394 (2000) PMID: 10025631

I.-Y. Choi, S.-P. Lee, S.-G. Kim, R. Gruetter, In vivo measurements of brain glucose transport using a reversible Michaelis-Menten model and comparison with cerebral blood flow changes during hypoglycemia.  J Cereb Blood Flow Metab 21:653 - 663 (2001) PMID: 11488534

I.-Y. Choi, H. Lei, R. Gruetter, Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo.: On the correlation of total glucose consumption with glutamatergic action.  J Cereb Blood Flow Metab 22(11):1343 - 1351 (2002) PMID: 12439292

I.-Y. Choi, C. Wu, D. Okar, A. J. Lange, R. Gruetter, Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo 13C NMR measurements of hepatic carbohydrate metabolism..  Euro J Biochem 269(18):4418 - 4426 (2002) PMID: 12230553

I.-Y. Choi, R. Gruetter, In vivo 13C NMR assessment of brain glycogen concentration and turnover in the awake rat.  Neurochem Int 43:317 - 322 (2003) PMID: 12742075

I.-Y. Choi, E. R. Seaquist, R. Gruetter, Effect of hypoglycemia on brain glycogen metabolism in vivo.  J Neurosci Res 72(1):25 - 32 (2003) PMID: 12645076

I.-Y. Choi, S.-P. Lee, D. N. Guilfoyle, J. A. Helpern, In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models  Neurochemical Res 28(7): 987 - 1001 (2003) PMID: 12737523

I.-Y. Choi, R. Gruetter, Dynamic or inert metabolism? Turnover of N-acetyl-aspartate and glutathione from [1-13C] D-glucose in the rat brain in vivo.  J Neurochem 91(4):778 - 787 (2004) PMID: 15525331

I.-Y. Choi, S.-P. Lee, H. Merkle and J. Shen, Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo.  Magn Reson Med 51:1115 - 1121 (2004) PMID: 15170830

I.-Y. Choi, S.-P. Lee and J. Shen, Selective homonuclear Hartmann-Hahn transfer method for in vivo spectral editing in the human brain.  Magn Reson Med 53:503 - 510 (2005) PMID: 15723418

I.-Y. Choi, S.-P. Lee and J. Shen, In vivo single-shot three-dimensionally localized multiple quantum spectroscopy of GABA in the human brain with improved spectral selectivity.  J Magn Reson 172(1):9 - 16 (2005) PMID: 15589402

G. Öz, I. Tkáč, I.-Y. Choi, K. J. Bjoraker, E. G. Shapiro, L. R. Charnas and R. Gruetter, Assessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients.  Neurology 64(3):434 - 441 (2005) PMID: 15699371

I.-Y. Choi, S.-P. Lee, H. Merkle and J. Shen, In vivo detection of gray and white matter differences in GABA concentration in the human brain.  NeuroImage 33(1):85-93 (2006) PMID: 16884929

I.-Y. Choi, S.-P. Lee, M. Garwood and K. Ugurbil, H. Merkle, Simple partial volume transceive coils for in vivo 1H MR studies at high magnetic fields. Concepts in Magnetic Resonance Part B: Magn Reson Engineering 31B (2):71-85 (2007)

X. Bao, R. Pal, K. N. Hascup, Y. Wang, W.-T. Wang, W. Xu, D. Hui, A. Agbas, X. Wang, M. L. Michaelis, I.-Y. Choi, A. B. Belousov, G. A. Gerhardt., E. K. Michaelis, Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.  Journal of Neuroscience 29(44):13929-44 (2009) PMID: 19890003

I.-Y. Choi, S.-P. Lee, D. R. Denney, S. G. Lynch, Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T.  Multiple Sclerosis, 17(3): 289-296 (2011) PMID: 20921235

J. Lu, E. Lezi, J. Frontera, W. Wang, H. Zhu, W-T. Wang, P. Lee, I.-Y. Choi, W. Brooks, J. M. Burns, D. Aires, R. H. Swerdlow, Alternate day fasting impacts the brain insulin signaling pathway of young adult male C57BL/6 Mice.  J Neurochem 117(1):154-63 (2011) PMID: 21244426

J. Kim, I.-Y. Choi, M. L. Michaelis, P. Lee, Quantitative in vivo measurement of early axonal transport deficits in a triple transgenic mouse model of Alzheimer's disease using manganese enhanced MRI.  NeuroImage, 56(3):1286-92 (2011) PMID: 21338698

C.M. Cirstea, W.M. Brooks, C.S. Craciunas, A.E. Popescu, I.-Y. Choi, P. Lee, A. Bani-Ahmed, H. Yeh, C.R. Savage, L.G. Cohen, R. Nudo, Primary motor cortex in stroke - a functional MRI-guided proton magnetic resonance spectroscopic study.  Stroke, 42(4):1004-9 (2011) PMID: 21330627

C.M. Cirstea, R. Nudo, C.S. Craciunas, A.E. Popescu, I.-Y. Choi, P. Lee, H.-W. Yeh, C. Savage, W.M. Brooks, Neuronal-glial alterations in non-primary motor areas in chronic subcortical stroke.  Brain Res 1463:75-84 (2012) PMID: 22575560

W.-T. Wang, P. Lee, I.V. Smirnova, I.-Y Choi, Effects of acute- and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo 1H MR spectroscopy at 9.4 T.  J Neurochem 121(3):407-417 (2012) PMID: 22353009

I.-Y. Choi, P. Lee, Doubly selective multiple quantum chemical shift imaging and T1 relaxation time measurement of glutathione (GSH) in the human brain in vivo.  NMR in biomedicine 26(1):28-34 (2012) PMID: 22730142

I.-Y. Choi, R. Gruetter,"Neural Metabolism In vivo". The Springer Science book series Advances in Neurobiology, Editors: In-Young Choi, Rolf Gruetter, 1190 pages (2012) ISBN-13: 978-1461417873

J. L. Harris, H.-W. Yeh, I.-Y. Choi, P. Lee, N. Berman, R. Swerdlow, S. Craciunas, W. M. Brooks, Altered neurochemical profile following traumatic brain injury: 1H-MRS biomarkers of pathological mechanisms.  J Cereb Blood Flow Metab, 32(12):2122-34 (2012) PMID: 22892723

C.M. Cirstea, R. Nudo, C.S. Craciunas, A.E. Popescu, I.-Y. Choi, P. Lee, H.-W. Yeh, C. Savage, W.M. Brooks, Motor and Premotor Cortices in Subcortical Stroke: Proton Magnetic Resonance Spectroscopy Measures and Arm Motor Impairment.  Neurorehabil Neural Repair 27(5):411-20 (2013) PMID: 23300210

C.M. Cirstea, R. Nudo, C.S. Craciunas, A.E. Popescu, I.-Y. Choi, P. Lee, H.-W. Yeh, C. Savage, W.M. Brooks, Handgrip-related activation in primary motor cortex relates to underlying neuronal metabolism after stroke.  Neurorehabil Neural Repair 28(5):433-442 (2013) PMID: 24376066

I.-Y. Choi, P. Lee, W.T. Wang, D. Hui, X. Wang, W. M. Brooks, E. K. Michaelis, Cerebral metabolism changes during aging in the hippocampus and striatum of Glud1 (Glutamate Dehydrogenase 1) transgenic mice.  Neurochem Res 39(3):446-55 (2014) PMID: 24442550

J. L. Harris, H.-W. Yeh, R. Swerdlow, I.-Y. Choi, P. Lee, W. M. Brooks, High field 1H-MRS reveals metabolic effects of normal brain aging.  Neurobiol of Aging 35:1686-1694 (2014) PMID: 24559659

J. Kim, I.-Y. Choi, Y. Dong, W.T. Wang, W.M. Brooks, C.P. Weiner, P. Lee, Chronic fetal hypoxia affects axonal maturation in guinea pigs during development: a longitudinal Diffusion Tensor Imaging and T2 mapping study.  J Magn Res Imag (2014) doi: 10.1002/jmri.24825. PMID: 25504885

A. Khowaja, I.-Y. Choi, E. Seaquist, G. Oz, In vivo magnetic resonance spectroscopy of cerebral glycogen metabolism in animals and humans.  Metab Brain Dis 30(1):255-61 (2015) PMID: 24676563

I.-Y. Choi, P. Lee, D.R. Denney, K. Spaeth, O. Nast, L. Ptomey, A.K. Roth, J.A. Lierman, D.K. Sullivan. Dairy intake is associated with brain glutathione concentrations in older adults.  Am J Clin Nutr 101(2):287-93 (2015) PMID: 25646325

Last modified: May 01, 2015

In-Young Choi, Ph.D.

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In-Young Choi, Ph.D.
Associate Professor

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