Molecular & Integrative Physiology
PhD Calcutta University, Calcutta, India, 1991
My formal training was in biochemistry, but for last fourteen years I have been engaged in the studies of the nervous system. I have become fascinated by mechanisms of plasticity in the sensory nervous system, particularly with regard to pain pathways. I have explored the role of multiple mechanisms and molecules that lead to sensory nociceptor sprouting, a highly prevalent yet poorly studied phenomenon associated with several pain syndromes. My research has demonstrated the effect of estrogen on neurite outgrowth and sensory axon remodeling in inflammatory conditions. In a seminal study we reported that the angiotensin II receptor type 2 (AT2) expressed in sensory nociceptors is an essential regulator of axon sprouting, and estrogen acts on sensory neurons through upregulation of this receptor. These findings have opened new directions in our understanding of complex diseases like female pelvic pain syndromes and inflammatory pain. On the basis of this we have developed animal models in rat to study pain mechanisms in inflammation. Recently, we developed a rat model that closely resembles human vulvar vestibulitis syndrome at behavioral, histological and molecular levels.
Anuradha Chakrabarty, PhD
3901 Rainbow Blvd.
Smith Lab - 2010 HLSIC
Kansas City, KS 66160