Dharmalingam Subramaniam, Ph.D.

Research Assistant Professor
University of Madras, Chennai, India, 2003

Research Overview

My research is focused on gastrin mediated carcinogenesis and chemoprevention.

a) My primary goal is to understand the mechanisms by which gastric epithelial cells respond to small peptide hormones gastrin and pro-gastrin, and also to infection by Helicobacter pylori, a gram negative, microaerophlic, spiral shaped bacilli. Infection with Helicobacter pylori results in hypergastrenemia and gastric cancer.  We aim to determine the different gastrin-induced cellular signaling response in gastric and colon epithelial cells and its subsequent effects on the expression of proinflammatory gene COX-2 and IL-8 expression at the transcriptional and posttranscriptional levels.

b) Chemoprevention, to determine the signaling mechanisms by dietary phyto-chemicals inhibit the growth of colon and pancreatic cancer cells.

Selective Publications

  • Subramaniam, D., Ramalingam, S, Houchen, C.W Anant, S. (2010). Cancer    Stem Cells: a novel paradigm for cancer prevention and treatment. Mini-reviews in Medicinal Chemistry. 10(5): 359-71.
  • Pantazis, P., Simpson-Durand, C., Varman, A., Thorpe, J., Ramalingam, S., Subramaniam, D., Houchen, C.W., Anant, S., and Ramanujam, R.P.  (2009). Turmeric and curcumin­ attenuate arsenic-induced angiogenesis in OVO.  Alternative Therapies Health and Medicine, 16(2): 12-14.
  • Kersulyte, D., Lee W.K., Subramaniam, D., Anant, S., Herrea, P., Csbrera, L., Balqui, J., Kalia, A.,and Berg, D.E.(2009).   Helicobacter pylori plasticity zones: novel transposable elements.  PLoS ONE, 4(9):e6859.
  • Sureban, M.S., May, R., Ramalingam. S., Subramaniam, D., Natarajan, G., Anant, S., and Houchen, C.W. (2009). Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a microRNA dependent mechanism. Gastroenterology, 137(4): 649-659.
  • Subramaniam, D., Ramalingam, S., May, R., Dieckgraefe, B.K., Berg, D.E., Pathoulakis, C., Houchen, C.W., Wang, T.C., and Anant, S. (2008).   Differential signaling pathways regulate gastrin-mediated transcriptional and post-transcriptional control of COX-2 and IL-8 gene expression in gastric epithelial cells. Gastroenterology, 134(4): 1070-1082.
  • Subramaniam, D., May, R., Sureban, S.M., Lee, K.B., George R., Kuppusamy, P., Ramanujam, R.P., Hideg, K., Dieckgraefe, B.K., Houchen, C.W and Anant, S. (2008). Diphenyl difluroketone (EF24): A curcumin derivative with potent in vitro and in vivo anti cancer activity. Cancer research 68(6):1962-9.
  • Subramaniam, D., Giridharan, P.,  Murmu, N., Shankarnarayanan, N.P., May, R., Houchen, C.W., Ramanujam, R.P., Balakrishnan, A., Vishwakarma, R.A. and Anant, S (2008). Activation of apoptosis by 1-hydroxy-5, 7-dimethoxy-2-napthaelene-carboxaldehyde, a novel compound from Agle marmelos.  Cancer Research, 68(20): 1-9.
  • Sureban, M.S., Ramalingam. S., Natarajan, G., May, R., Subramaniam, D., Bishupuri, K.S., Dieckgraefe, B.K., Houchen, C.W., and Anant, S. (2008). RBM3, a protooncogenic RNA binding protein overexpressed in colon cancer cells. Oncogene, 27(17):1-13.  
  • Subramaniam, D., Natarajan G., Ramalingam, S., Ramachandran I., May, R., Qeimado L., Houchen, C.W., and Anant, S (2008).   Translation control during mitotic catastrophe: Mcl-1 is a novel target for RNA binding protein CUGBP2. American Journal of Physiology Gastrointestinal Liver physiology, 294(4):G1025-32.
  • Kersulyte, D., Kalia, A., Zhang, M., Lee, H., Subramaniam, D., Kiuduliene, L., Chalkauskas, H., Janulaitis, A. and Berg, D.E. (2005). Sequence organization and insertion specificity of the novel chimaeric ISHp609 transposable element of Helicobacter pylori. Journal of Bacteriology, 186(22): 7521-8.
  • Thyagarajan, S.P., Ray, P., Das, B.K., Ayyagari, A., Khan, A.A., Subramaniam, D., Rao, U.A,, Rajasambandam, P., Ramathilagam, B.,  Bhasin, D., Sharma, M.P., Naik, S.R .and Habibullah, C.M. (2003).  Geographical difference in antimicrobial resistance pattern of Helicobacter pylori clinical isolates from Indian patients: a multicentric study. Journal of Gastroenterology and Hepatology, 18(12):1373-8.
  • Subramaniam, D., Rao, U.A, Jayaraman, G. and Thyagarajan, S.P. (2001).  Relationship of plasmid profile with the antibiotic sensitivity pattern of Helicobacter pylori isolates from peptic ulcer disease patients in Chennai. Indian Journal of Medical Microbiology, 21(4): 257-261
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Dharmalingam Subramaniam, Ph.D.
Research Assistant Professor

4019 Wahl Hall East
3901 Rainbow Blvd.
Kansas City, KS 66160

P: (913) 945-6333
F: (913) 588-7430