University of Delhi, India, 1988
Postdoc: Vollum Institute, Oregon Health Sciences University, Portland, Oregon
Postdoc: Baylor College of Medicine, Houston, Texas
Genetic approaches to study the development and physiology of the mammalian reproductive axis
Our laboratory studies development and regulation of the hypothalamus-pituitary-gonadal (HPG) axis using both gain-of-function transgenic and loss-of-function gene knockout approaches. These unique genetic models mimic many of the human diseases and thus enable us to experimentally tract them spatio-temporally. Specific projects include unraveling signaling pathways in the hypothalamus that contribute to male sexual behavior, understanding human pituitary null cell tumor pathobiology and developing preventive strategies, delineating mechanisms of secretion of pituitary gonadotropins, and age-dependent gonadotropin regulation of testis and ovarian development and function. These translational studies have significant impact in understanding the physiology and pathology of the reproductive axis including abnormal reproductive tract development, infertility, and cancer of the pituitary and gonads.
Wang H, Graham I, Hastings R, Gunewardena S, Brinkmeier ML, Conn PM, Camper SA, Kumar TR. (2015) Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects. Journal of Biological Chemistry, 290: 2699-2714.
Wang H, Larson M, Shariff AJ, Pearl C, Miller WL, Conn PM, Boime I and Kumar TR. (2014) Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function. Proceedings of The National Academy of Sciences (USA), 111: 5735 - 5740.
Oury F, Mathieu F, Lin, X, Prashanth S, Wang, H, Cyrille C, Julie C, Francesca L, Ali G, Herve L, Kumar TR, Ingrid P, Karsenty G (2013) Evidence for a pancreas-bone-testis axis in the mouse and for the conservation of osteocalcin function in humans. Journal of Clinical Investigation 123: 2421- 2433.
Abel MH, Charlton HM, Huhtaniemi I, Pakarinen P, Kumar TR, Christian HC (2013) An investigation into pituitary gonadotrophic hormone synthesis, secretion, subunit gene expression and cell structure in normal and mutant male mice. Journal of Neuroendocrinology, 25: 863-875.
Wang H and Kumar TR (2012) Segment- and cell- specific expression of D-type cyclins in the postnatal mouse epididymis. Gene Expression Patterns, 12: 136-144.
Panneerdoss S, Fu-Chang Y, Buddavarapu K, Shetty G, Wang H, Kumar TR and Rao MK (2012) Androgen-responsive microRNAs in Sertoli cells. PLoS One, 7: e41146.
Iqbal J, Sun L, Kumar TR, Blair HC and Zaidi M (2006). FSH Stimulates TNF production from immune cells: A novel mechanism for hypogonadal bone loss. Proceedings of The National Academy of Sciences (USA), 103: 14925-14930.
Shariff AJ*, Kumar TR*, Eklund, J and Boime I (2006). Single chain triple domain gonadotropin analogs with disulfide bond mutations in the alpha subunit elicit dual FSH and LH activities in vivo. Molecular Endocrinology, 20: 1437-1446. * Equal contribution
Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, et al., (2006). FSH directly regulates bone mass: implications for understanding the pathogenesis of the osteoporosis due to hypogonadism. Cell, 125: 247-260.
Kumar TR, Schuff KG, Nusser KD and Low MJ (2006). Gonadotroph-specific expression of the human follicle-stimulating hormone beta gene in transgenic mice. Molecular and Cellular Endocrinology, 247:103-115.
Ma X, Reyna A, Mani SK, Matzuk MM and Kumar TR (2005). Impaired male sexual behavior and reduced NOS activity in the medial pre-optic area in activin receptor II knockout mice. Biology of Reproduction, 73:1182-1190.
Ma X, Dong YL, Matzuk MM and Kumar TR (2004). Targeted mutagenesis of LH beta leads to hypogonadism, defects in steroidogenesis and infertility. Proceedings of National Academy of Sciences (USA), 101: 17294-17299.
Garcia-Campayo V, Boime I, Xiaoping Ma, Iken DD and Kumar TR (2004). A tetradomain single chain glycoprotein analog elicits multiple hormone activities in vivo. Biology of Reproduction, 72: 301-308.
Matzuk MM, Hadsell, LA, De Mayo F and Kumar TR (2003). Overexpression of human chorionic gonadotropin in transgenic mice causes multiple reproductive defects. Biology of Reproduction, 338-346.
Kumar TR, Graham KE, Asa SL and Low MJ (1998). Simian Virus 40-T Antigen induced gonadotroph adenomas: a model of human null-cell adenomas. Endocrinology, 139: 3342-3351.
Kumar TR, Lu H, Wang Y, and Matzuk MM (1997). Follicle Stimulating hormone is required for ovarian follicle maturation but not male fertility. Nature Genetics,15: 201-204. Matzuk MM,
Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM (1996). Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature, 383: 531-535.
Kumar TR and Bradley, A (1995). Different phenotypes for mice deficient in either activins or activin receptor type II. Nature, 374: 356-360.
Matzuk MM, Kumar TR, Vassali A, Bickenbach JR, Roop DR, Jaenisch R and Bradley A (1995). Functional analysis of activins in mammalian development. Nature, 374: 354-356.
National Institute on Aging (NIA) and National Cancer Institute (NCI)
T. Rajendra Kumar, Ph.D.
3901 Rainbow Blvd.
Kansas City, KS 66160
F: (913) 588-7430