Steven M. LeVine, Ph.D.

Professor
Albert Einstein College of Medicine, 1987


Research Focus

  • Neurobiology - multiple sclerosis and globoid cell leukodystrophy
  • Vascular - blood-brain barrier disruption and bacteria or toxin induced vessel injury

Research Interests

Our studies utilize a team approach to perform translational research that is directed at identifying pathogenic mechanisms and novel interventions for multiple sclerosis, which is a neurological disease that can cause sensory, motor and/or cognitive declines. Additional collaborative studies address intervention strategies for globoid cell leukodystrophy (Krabbe's disease) and identifying mechanisms of bacteria or toxin induced vessel injury.

Selected Publications

Iron deposits in a cerebral model of multiple sclerosis
Iron deposits in a cerebral model of multiple sclerosis

 

Multiple Sclerosis

Weigel KJ Lynch SG, LeVine SM.  Iron chelation and multiple sclerosis. ASN Neuro. 2014; 6(1):e00136. Review.

Sands SA, Williams R, Marshall 3rd S, LeVine SM. Perivascular iron deposits are associated with protein nitration in cerebral experimental autoimmune encephalomyelitis. Neurosci. Lett. 2014; 582:133-138

Sands SA, Tsau S, Yankee TM, Parker BL, Ericsson AC, LeVine SM. The effect of omeprazole on the development of experimental autoimmune encephalomyelitis in C57BL/6J and SJL/J mice. BMC Res. Notes 2014; 7:605.

Tsau S, Emerson RM, Lynch SG, LeVine SM. Aspirin and multiple sclerosis. BMC Med. 2015; 13:153.Review.

Krabbe Disease (globoid cell leukodystrophy)

Pedchenko TV, LeVine SM.  IL-6 deficiency results in enhanced pathology in twitcher (globoid cell leukodystrophy) mice. Exp. Neurol.1999; 158:459-468.

LeVine SM, Pedchenko TV, Bronshteyn IG, Pinson D. L-Cycloserine reduces clinical and pathological signs in mice with globoid cell leukodystrophy (twitcher mice). J. Neurosci. Res. 2000; 60:231-236.

PAS positive globoid cells in a mouse model of Krabbe disease
PAS positive globoid cells in a mouse model of Krabbe disease

Biswas S, LeVine SM. Substrate reduction therapy enhances the benefits of bone marrow transplantation in young mice with globoid cell leukodystrophy. Pediatric Res. 2002; 51:40-47.

Biswas S, Biesiada H, Williams TD, LeVine SM. Substrate reduction intervention by L-cycloserine in twitcher mice (globoid cell leukodystrophy) on a B6;CAST/Ei background. Neurosci. Lett. 2003; 347:33-36.

Toxin Injury

Culley NC, Pinson DM, Chakrabarty A, Mayo MS, LeVine SM. Pathophysiological manifestations in mice exposed to anthrax lethal toxin. Infect. Immun. 2005; 73:7006-7010.

Terra JK, Cote CK, France B, Jenkins AL, Bozue JA, Welkos SL, LeVine SM, Bradley KA. Cutting edge: Resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J. Immunol. 2010; 184:17-20.

Terra JK, France B, Cote CK, Jenkins A, Bozue JA, Welkos SL, Bhargava R, Mehrabian M, Pan C, Lusis AJ, Davis RC, LeVine SM, Bradley KA. Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. PLoS Pathog. 2011; 7(12):e1002469.

Weigel KJ, Rues L, Doyle EJ, Buchheit CL, Wood JG, Gallagher RJ, Kelly LE, Radel JD, Bradley KA, LeVine SM. Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background.  PLoS ONE 2012; 7(7):e40126.

Methods and Designs

Wetzel DL, LeVine SM. Imaging molecular chemistry with infrared microscopy. Science 1999; 285:1224-1225.

Esch SW, Williams TD, Biswas S, Chakrabarty A, LeVine SM.  Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: A lipidomics approach. Cell. Mol. Biol. (Noisy-le-grand) 2003; 49:779-787.

Fleming KK, Bovaird JA, Mosier MC, Emerson MR, LeVine SM, Marquis JG. Statistical analysis of data from studies on experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005; 170:71-84. Review.

Emerson MR, Gallagher RJ, Marquis JG, LeVine SM.  Enhancing the ability of experimental autoimmune encephalomyelitis to serve as a more rigorous model of multiple sclerosis through refinement of the experimental design.  Comp. Med. 2009; 59:112-128.  Review.

Last modified: Jul 06, 2015

Contact

Steven M. LeVine, Ph.D.
Professor

2016 Smith East
3901 Rainbow Blvd.
Kansas City, KS 66160

P: (913) 588-7420
F: (913) 588-7430
slevine@kumc.edu

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