Steven M. LeVine, Ph.D.

Professor
Albert Einstein College of Medicine, 1987


Research Focus

  • Neurobiology - multiple sclerosis and globoid cell leukodystrophy
  • Vascular - blood-brain barrier disruption and bacteria or toxin induced vessel injury

Research Interests

Our studies utilize a team approach to perform translational research that is directed at identifying pathogenic mechanisms and novel interventions for multiple sclerosis, which is a neurological disease that can cause sensory, motor and/or cognitive declines. Additional collaborative studies address intervention strategies for globoid cell leukodystrophy (Krabbe's disease) and identifying mechanisms of bacteria or toxin induced vessel injury.

Selected Publications

Iron deposits in a cerebral model of multiple sclerosis
Iron deposits in a cerebral model of multiple sclerosis

Multiple Sclerosis

Williams R, Rohr AM, Wang W-T, Choi I-Y, Lee P, Berman NEJ, Lynch SG and LeVine SM (2011) Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis. BMC Neurosci. 12:59.

Williams R, Buchheit CL, Berman NEJ and LeVine SM (2012) Pathogenic implications of iron accumulation in multiple sclerosis. J. Neurochem. 120:7-25. Review

Weigel, KJ, Lynch, SG and LeVine, SM (2014) Iron chelation and multiple sclerosis. ASN Neuro. 6(1):art:e00136 Review

Sands SA, Williams R, Marshall 3rd S and LeVine SM (2014) Perivascular iron deposits are associated with protein nitration in cerebral experimental autoimmune encephalomyelitis. Neurosci. Lett. pii: S0304-3940(14)00368-1.

Sands, SA, Tsau, S, Yankee, TM, Parker, BL, Ericsson, AC, and LeVine, SM (2014) The effect of omeprazole on the development of experimental autoimmune encephalomyelitis in C57BL/6J and SJL/J mice. BMC Res. Notes 7:605.

Krabbe Disease (globoid cell leukodystrophy)

Pedchenko TV and LeVine SM (1999) IL-6 deficiency results in enhanced pathology in twitcher (globoid cell leukodystrophy) mice. Exp. Neurol. 158:459-468.

LeVine SM, Pedchenko TV, Bronshteyn IG and Pinson D (2000) L-Cycloserine reduces clinical and pathological signs in mice with globoid cell leukodystrophy (twitcher mice). J. Neurosci. Res. 60:231-236.

PAS positive globoid cells in a mouse model of Krabbe disease
PAS positive globoid cells in a mouse model of Krabbe disease

Biswas S and LeVine SM (2002) Substrate reduction therapy enhances the benefits of bone marrow transplantation in young mice with globoid cell leukodystrophy. Pediatric Res. 51:40-47.

Biswas S, Biesiada H, Williams TD and LeVine SM (2002) Delayed clinical and pathological signs in twitcher (globoid cell leukodystrophy) mice on a C57BL/6 x CAST/Ei background. Neurobiol. Dis. 10:344-357.

Biswas S, Biesiada H, Williams TD and LeVine SM (2003) Substrate reduction intervention by L-cycloserine in twitcher mice (globoid cell leukodystrophy) on a B6;CAST/Ei background. Neurosci. Lett. 347:33-36.

Toxin Injury

Culley NC, Pinson DM, Chakrabarty A, Mayo MS and LeVine SM (2005) Pathophysiological manifestations in mice exposed to anthrax lethal toxin. Infect. Immun. 73:7006-7010.

Terra JK, Cote CK, France B, Jenkins AL, Bozue JA, Welkos SL, LeVine SM and Bradley KA (2010) Cutting edge: Resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b. J. Immunol. 184:17-20.

Terra JK, France B, Cote CK, Jenkins A, Bozue JA, Welkos SL, Bhargava R, Mehrabian M, Pan C, Lusis AJ, Davis RC, LeVine SM and Bradley KA (2011) Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. PLoS Pathog. 7(12): e1002469.

Weigel KJ, Rues L, Doyle EJ, Buchheit CL, Wood JG, Gallagher RJ, Kelly LE, Radel JD, Bradley KA and LeVine SM (2012) Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background. PLoS ONE 7(7): e40126.  

Methods and Designs

Wetzel DL and LeVine SM (1999) Imaging molecular chemistry with infrared microscopy. Science 285:1224-1225.

Esch SW, Williams TD, Biswas S, Chakrabarty A and LeVine SM (2003) Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: A lipidomics approach. Cell. Mol. Biol. (Noisy-le-grand) 49:779-787.

Fleming KK, Bovaird JA, Mosier MC, Emerson MR, LeVine SM and Marquis JG (2005) Statistical analysis of data from studies on experimental autoimmune encephalomyelitis. J. Neuroimmunol. 170:71-84. Review.

Emerson MR, Gallagher RJ, Marquis JG and LeVine SM (2009) Enhancing the ability of experimental autoimmune encephalomyelitis to serve as a more rigorous model of multiple sclerosis through refinement of the experimental design. Comp. Med. 59:112-128. Review.

Last modified: Oct 07, 2014

Contact

Steven M. LeVine, Ph.D.
Professor

2016 Smith East
3901 Rainbow Blvd.
Kansas City, KS 66160

P: (913) 588-7420
F: (913) 588-7430
slevine@kumc.edu

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