Sam J. Enna, Ph.D.

Professor, Associate Dean for Research and Graduate Education
University of Missouri Kansas City, 1970

Research Focus

Brain neurotransmitter receptors

Research Description

Research in my laboratory has been aimed at defining the molecular, biochemical and pharmacological properties of brain receptors, particularly those associated with amino acid neurotransmitters. In recent years emphasis has been on examining the regulation, expression and function of γ-aminobutyric acid B (GABA B) receptors in brain. Besides providing new information on the role of this receptor in the response to physiological and pharmacological manipulations, these studies provided new insights into the genomic and nongenomic regulation of this heterodimeric, G protein-coupled receptor. Laboratory techniques include in situ hybridization, immunohistochemistry, analysis of cyclic AMP production, Western blotting, solution hybridization nucleus protection assays, and behavioral analyses.

Selected Recent Publications

Enna, S.J. and Williams, M. Challenges in the Search for Drugs to Treat Central Nervous System Disorders. J. Pharmacol. Exptl. Therap., 329:1-8, 2009.

Enna, S.J. and Williams, M. Defining the Role of Pharmacology in the Emerging World of Translational Research. In: Contemporary Aspects of Biomedical Research: Drug Discovery. Advances in Pharmacology (S.J. Enna and M.J. Williams, eds), pp. 1-30, Academic Press, New York, 2009.

Obaidat, A., Weiss J., Wahlgren, B., Manam, R.R., Macheria, V.R., McArthur, K., Chao, T., Palladino, M.A., Lloyd, K.G., Potts, B.C., Enna, S.J., Neuteboom, S., and Hagenbuch, B. Proteasome Regulator Marizomib (NPI-0052) Exhibits Prolonged Inhibition, Attenuated Efflux, and Greater Cytotoxicity than Its Reversible Analogs.  J. Pharmacol. Exptl. Therap. 337:479-486, 2011.

Ghose, S., Winter, M.K., McCarson, K.E., Tamminga, C.A., and Enna, S.J.  The GABA-B Receptor as a Target for Antidepressant Drug Action. Br. J. Pharmacol. 162:1-17, 2011.

Enna, S.J. A Legacy of Discovery: From Monoamines to GABA. Neuropharmacology 60:1050-1057, 2011.

Williams, J., and Enna, S.J. Prospects for Neurodegenerative and Psychiatric Disorder Drug Discovery. Expert Opin. Drug Discovery 6:457-463, 2011.

Enna, S.J. Extrasynaptic Site of Action for γ-Hydroxybutyrate. Proc. Natl. Acad. Sci. (USA) 109:13142-13143, 2012.

Enna, S.J., and Bowery, N.G. GABA-B Receptor. In: The Encyclopedia of Biological Chemistry (W.J. Lennarz and M.D. Lane, eds), Vol. 2, pp. 351-353, Academic Press, New York, 2013.

Enna, S.J., and Norton, S. Herbal Supplements and the Brain. FT Press, New York, 252 pp., 2012

McCarson, K.E., and Enna, S.J. GABA Pharmacology: The Search for Analgesics. Neurochem. Res., in press, 2014.


Editorial and Administrative Staff
Lynn Lecount-Clark: Managing Editor
Jennifer McNichols: Editorial Coordinator
Leigh Ann Arbuckle: Senior Coordinator

Last modified: Dec 24, 2013

S. J. Enna, Ph.D.


Sam J. Enna, Ph.D.
Professor, Associate Dean for Research and Graduate Education

Smith East; MS-4016
3901 Rainbow Blvd.

P: (913) 588-7533
F: (913) 588-7373