University of Cambridge, England, 1977
Reproduction - regulation of flagellar motility by protein phosphorylation
The overall goal of our research is to understand the mechanism involved with regulation of sperm movement and the factors that influence sperm production and maturation leading to the ability to fertilize. Our NIH-funded research is using a combination of medicinal chemistry and proteomics to determine the mechanism of action and testing of small molecular reversible anti-spermatogenic compounds as non-hormonal non-steroidal male contraceptives. Research funded by NASA is focused on the effect of space flight on signal transduction in the sperm during sperm activation and fertilization. This has lead to a more detailed investigation on the impact of long term space flight on male fertility.
J. S. Tash, D. C. Johnson, and G. C. Enders. Long-term (6-week) hindlimb suspension inhibits spermatogenesis in adult male rats. J.Appl.Physiol 92 (3):1191-1198, 2002.
J. S. Tash, S. Kim, M. Schuber, D. Seibt, and W. H. Kinsey. Fertilization of sea urchin eggs and sperm motility are negatively impacted under hypergravitational forces significant to space flight. Biol.Reprod. 65 (4):1224-1231, 2001.
J. S. Tash and G. E. Bracho. Microgravity alters protein phosphorylation changes during initiation of sea urchin sperm motility. FASEB J. 13:S43-S54, 1999.