John G. Wood, Ph.D.

Associate Professor
University of Michigan, 1980


Research Focus

Cardiovascular - microcirculation

Research Interests

Systemic hypoxia occurs at high altitude and in a variety of cardio-pulmonary diseases. Few studies have examined its effects on the microcirculation despite considerable clinical evidence suggestive of microvascular inflammation during hypoxia (i.e., high altitude cerebral edema). In fact, it is generally accepted that microvascular injury occurs during elevated tissue oxygen levels (during reperfusion of organs after prolonged ischemia) rather than during low tissue oxygen levels during ischemia. Currently, our major goal is to examine mechanisms responsible for microvascular inflammation during acute systemic hypoxia as well as the mechanisms involved in adaptation to chronic hypoxia. These studies are in collaboration with Dr. Norberto Gonzalez.

Publications

Forster J, P Beebee, H Wang, and JG Wood. Effect of L-NAME on systemic blood pressure differs between rat strains. J Surg Res 96:218-223, 2001.

Steiner DRS, Gonzalez NC, and JG Wood. Leukotriene B4 promotes reactive oxidant generation and leukocyte adherence during acute hypoxia. J Appl Physiol 91:1160-1167, 2001.

Gonzalez NC and JG Wood. Leukocyte-endothelial interactions in environmental hypoxia. Adv Exp Med Biol 502:39-60, 2001.

Steiner DRS, NC Gonzalez, and JG Wood. Interaction between reactive oxygen species and nitric oxide in the microvascular response to systemic hypoxia. J Appl Physiol 93:1411-1418, 2002.

Childs EW, KF Udobi , JG Wood, FA Hunter, DM Smalley, and LY Cheung. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. Shock 18:423-7, 2002.

Steiner DRS, NC Gonzalez, and JG Wood. Mast cells mediate the microvascular inflammatory response to systemic hypoxia. J Appl Physiol 94:325-334, 2003.

Gonzalez NC, Steiner DRS, and Wood JG. Dexamethasone prevents the microcirculatory inflammatory response to systemic hypoxia. Health and Height. Proc 5th World Congress on Mountain Med High Altitude Physiology, pp. 31-38, 2003.

Casillan AJ, Gonzalez NC, Johnson JS, Steiner DRS, and Wood JG. Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. J Appl Physiol 94:2313-2322, 2003.

Shah S, Allen J, Wood JG, and Gonzalez NC. Dissociation between skeletal muscle microvascular PO2 and hypoxia-induced microvascular inflammation. J Appl Physiol 94:2323-2339, 2003.

Dix R, Orth T, Allen J, Wood JG, and Gonzalez NC. Activation of mast cells by systemic hypoxia, but not by local hypoxia, mediates increased leukocyte-endothelial adherence in cremaster venules. J Appl Physiol 95:2495-502, 2003.

Valenzeno DP, Wood JG, Gonzalez NC, and Tarr M. Photosensitization with emphasis on the cardiovascular system. In: CRC Handbook of Organic Photochemistry and Photobiology. Eds. W.M. Hospool and F. Lenci. CRC Press, Inc., Boca Raton, FL. 2003.

Schloerb PR, Wood JG, Casillan AJ, Tawfik O, and Udobi K.  Bowel necrosis caused by water in jejunal feeding. JPEN J Parenter Enteral Nut  28:27-29, 2004.

Orth TA, Allen JA, Wood JG, and Gonzalez NC. Exercise training prevents the inflammatory response to hypoxia in cremaster venules. J Appl Physiol 98:2113-2118, 2005.

Orth TA, Allen JA, Wood JG, and Gonzalez NC. Plasma from conscious hypoxic rats stimulates leukocyte-endothelial interactions in normoxic cremaster venules. J Appl Physiol 99:290-297, 2005.

Orth TA, Allen JA, Wood JG, and Gonzalez NC. Plasma from conscious hypoxic rats stimulates leukocyte-endothelial interactions in normoxic cremaster venules. J Appl Physiol  99:290-297, 2005.

Ho-Chen JK, Ain R, Alt AR, Wood JG, and Gonzalez NC, and Soares MJ. Hypobaric hypoxia as a tool to study pregnancy-dependent responses at the maternal-fetal interface. Methods Mol Med 122:427-434, 2006.

Wood JG and Gonzalez NC. Reactive oxygen species and the microcirculation. Encyclopedia of the Microcirculation, D. Shepro, Editor. P. 805-809, 2006.

Last modified: Apr 15, 2014

Contact

John G. Wood, Ph.D.
Associate Professor

1014B Smith East
3901 Rainbow Blvd.
Kansas City, KS 66160

P: (913) 588-7478
F: (913) 588-7430
jwood2@kumc.edu

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