John A. Stanford, Ph.D.
University of Kansas, 1998
Age-related changes in motor function
My research is focused on aging and age-related diseases and conditions that affect motor function, such as Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and stroke. My approach is best described as a systems neuroscience approach using rodent models. I have a longstanding interest in determining mechanisms that underlie, and potential treatments to ameliorate, age-related orolingual motor deficits. Recent efforts in my lab are underway to determine the effects of high fat diet-induced insulin resistance on neural function in order to understand the co-morbidity between obesity and neurodegenerative diseases. We are also studying the effects of isometric strength training on disease progression in the SOD1-G93A rat model of ALS. Finally, recent studies also include characterizing orolingual motor deficits and cortical motor plasticity following ischemic damage to tongue regions of the motor cortex.
Zhang H, Bethel CS, Smittkamp SE, Stanford JA (2008) Age-related changes in orolingual motor function in F344 vs F344/BN rats. Physiology & Behavior 93, 461-466.
Guggenmos DJ, Barbay S, Bethel-Brown CS, Nudo RJ, Stanford JA (2009) Effects of tongue force training on orolingual motor cortical representation. Behavioural Brain Research 201, 229-232.
Salvatore, MF, Gerhardt GA, Dayton RD, Klein RL, Stanford JA (2009) Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Experimental Neurology. 219, 197-207.
Smittkamp SE, Spalding H, Brown J, Gupte A, Chen J, Nishimune H, Geiger PC, Stanford JA (2010) Measures of bulbar and spinal motor function, muscle innervation, and mitochondrial function in ALS rats. Behavioural Brain Research 211, 48-57.
Morris JK, Bomhoff GL, Gorres BK, Davis VA, Kim J, Lee P, Brooks WB, Gerhardt GA, Geiger PC, Stanford JA (2011) Insulin resistance impairs nigrostriatal dopamine function. Experimental Neurology 231, 171-180.
Bethel-Brown CS, Morris JK, Stanford JA (2011) Young and middle-aged rats exhibit isometric forelimb force control deficits in a model of early-stage Parkinson’s disease. Behavioural Brain Research 225, 97-103.
Morris JK, Seim NB, Geiger PC, Stanford JA (2011) Effects of unilateral nigrostriatal dopamine depletion on peripheral glucose tolerance and insulin signaling in middle aged rats. Neuroscience Letters, 504, 219-222.
Nishimune H, Numata T, Chen J, Aoki Y, Wang Y, Starr MP, Mori Y, Stanford JA (2012) Active zone protein bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exercise. PLoS One, 7, e38029.
Nuckolls AL, Worley C, Leto C, Zhang H, Morris JK, Stanford JA (2012) Tongue force and tongue motility are differentially affected by unilateral vs bilateral nigrostriatal dopamine depletion in rats. Behavioural Brain Research, 234, 343-348.
Apr 15, 2014