John A. Stanford, Ph.D.
Program Director, Kansas IDeA Network of Biomedical Research Excellence (K-INBRE)
Program Director, KUMC Biomedical Research Training Program
University of Kansas, 1998
Motor function in neurological disorders across the lifespan
My research is focused on diseases and conditions that affect motor function, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), neonatal jaundice, and aging. My approach is best described as a systems neuroscience approach using operant behavioral methods in rodent models. I have a longstanding interest in determining mechanisms that underlie, and potential treatments to ameliorate, orolingual motor deficits in aging and in ALS. Recent efforts in my lab have focused on the effects of isometric strength training on disease progression in rat models of aging and ALS. I am also involved in research into determining the short- and long-term neurological effects of hyperbilirubinemia in rodent models of neonatal jaundice. Finally, I remain interested in the effects of metabolic challenges on neural function to understand the co-morbidity between obesity and neurodegenerative diseases.
Zhang H, Bethel CS, Smittkamp SE, Stanford JA (2008) Age-related changes in orolingual motor function in F344 vs F344/BN rats. Physiology & Behavior 93, 461-466.
Smittkamp SE, Brown J, Stanford JA (2008) Time-course and characterization of orolingual motor deficits in B6SJL-Tg(SOD1-G93A)1GUR/J mice. Neuroscience 151, 613-621.
Guggenmos DJ, Barbay S, Bethel-Brown CS, Nudo RJ, Stanford JA (2009) Effects of tongue force training on orolingual motor cortical representation. Behavioural Brain Research 201, 229-232.
Salvatore, MF, Gerhardt GA, Dayton RD, Klein RL, Stanford JA (2009) Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Experimental Neurology 219, 197-207.
Smittkamp SE, Spalding H, Brown J, Gupte A, Chen J, Nishimune H, Geiger PC, Stanford JA (2010) Measures of bulbar and spinal motor function, muscle innervation, and mitochondrial function in ALS rats. Behavioural Brain Research 211, 48-57.
Morris JK, Bomhoff GL, Gorres BK, Davis VA, Kim J, Lee P, Brooks WB, Gerhardt GA, Geiger PC, Stanford JA (2011) Insulin resistance impairs nigrostriatal dopamine function. Experimental Neurology 231, 171-180.
Bethel-Brown CS, Morris JK, Stanford JA (2011) Young and middle-aged rats exhibit isometric forelimb force control deficits in a model of early-stage Parkinson's disease. Behavioural Brain Research 225, 97-103.
Nishimune H, Numata T, Chen J, Aoki Y, Wang Y, Starr MP, Mori Y, Stanford JA (2012) Active zone protein bassoon co-localizes with presynaptic calcium channel, modifies channel function, and recovers from aging related loss by exercise. PLoS One 7, e38029.
Nuckolls AL, Worley C, Leto C, Zhang H, Morris JK, Stanford JA (2012) Tongue force and tongue motility are differentially affected by unilateral vs bilateral nigrostriatal dopamine depletion in rats. Behavioural Brain Research 234, 343-348.
Smittkamp SE, Spalding HN, Brown JW, Yeh H-W, Stanford JA (2014) Relationships between tongue motility, grip force, and survival in SOD1-G93A rats. Physiology and Behavior 125, 17-20.
Healy-Stoffel M, Ahmad SO, Stanford JA, Levant B (2014) Differential effects of intrastriatal 6-hydroxydopamine on cell number and morphology in midbrain dopaminergic subregions of the rat. Brain Research 1574, 113-119.
Stanford JA, Shuler JM, Fowler SC, Stanford KG, Ma D, Bittel DC, Le Pichon J-B, Shapiro SM (2015) Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits. Pediatric Research 77, 434-439.
Ma D, Shuler JM, Raider KD, Rogers RS, Wheatley JL, Geiger PC, Stanford JA (2015) Effects of discontinuing a high fat diet on mitochondrial proteins and 6-hydroxydopamine-induced dopamine depletion in rats. Brain Research 1613, 49-58.
Raider KD, Ma D, Harris JL, Fuentes I, Rogers RS, Wheatley JL, Geiger PC, Yeh HW, Choi I-Y, Brooks WM, Stanford JA (2016) Neurochemical Differences between high-fat-fed and chow-fed rats: A magnetic resonance spectroscopy study. Neurochemistry International 97, 172-180.
Ma D, Shuler JM, Kumar A, Tungtur S, Nishimune H, Stanford JA (2017) Tongue force training accelerates tongue motility deficits in the female SOD1-G93A rat model of Amyotrophic Lateral Sclerosis. Neurorehabilitation and Neural Repair 31, 147-156.
Yang F-C, Draper J, Smith PG, Vivian JL, Shapiro SM, Stanford JA (2018) Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain. Cell Transplantation 27, 654-665.
Gan L, Ma D, Li M, Yang F-C, Rogers RS, Wheatley JL, Koch LG, Britton SL, Thyfault JP, Geiger PC, Stanford JA (2018) Region-specific differences in bioenergetic proteins and protein response to acute high fat diet in brains of low and high capacity runner rats. Neuroscience Letters 674, 49-53.