Research Assistant Professor
University of Madras, Chennai, India, 2004
The goal of my research is to determine the role of RNA Binding proteins in tumor progression and metastasis.
Post-transcriptional regulation of gene expression by RNA binding protein is a crucial mechanism in regulating the timing and the amount of expression of genes. Growing evidence indicate that the alteration of the expression and function of RNA binding proteins could potentially play a role in inflammation and cancer. Hence, it is indispensable to identify the RNA binding protein alterations accumulate during cancer progression as well as during the acquisition of metastatic potential in cancer cells.
To understand the mechanisms behind the process of hemangiogenesis and lymphangiogenesis in metastasis.
Metastasis entails the spread of cancer cells from a primary tumor throughout the body through the blood or lymphatic systems. Hence, blocking angiogenesis could be a strategy to arrest tumor growth. Therefore, understanding the molecular mechanisms underlying the hemangiogenesis and lymphangiogenesis processes and their regulation will lead to the discovery of pharmaceutical agents with anti-angiogenic activity.
Ramalingam, S., Natarajan, G., Schafer, C., Subramaniam, D., May, R., Ramachandran, I., Lurdes, Q., Houchen, C. W., and Anant, S. (2008). Novel intestinal splice variants of RNA binding protein CUGBP2: Isoform specific effects on mitotic catastrophe. Am.J.Physiol Gastro Liver Physiol. 94(4):G971-81.
Sureban, S.M1., Ramalingam, S1., Natarajan, G., May, R., Subramaniam, D., Bishnupuri, K.S., Morrison, A.R, Dieckgraefe, B.K., Houchen, C.W., and Anant, S. 2008. RBM3, a protooncogenic RNA binding protein overexpression in colon cancers. Oncogene, 27(33):4544-56. (1Equal Contribution)
Subramaniam, D., Ramalingam, S., May, R., Dieckgraefe, B.K., Berg, D.E., Pothoulakis, C., Houchen, C.W., Wang, T.C., and Anant, S. 2008. Gastrin-mediated IL-8 and COX-2 gene expression: differential transcriptional and post-transcriptional mechanisms. Gastroenterology, 34(4):1070-82.
Subramaniam, D., Gopalan, N., Ramalingam, S., May, R., Houchen, C. W., and Anant, S. 2008. Translation inhibition during mitotic catastrophe: Mcl-1 is a novel target for RNA binding protein CUGBP2. Am J Physiol Gastrointest Liver Physiol. 294(4):G1025-32.
Gopalan, N., Ramalingam, S., Subramaniam, D., May, R., Ramachandran, I., Lurdes, Q., Houchen, C. W., and Anant, S. 2008. CUGBP2 Downregulation By Prostaglandin E2 protects Colon Cancer Cells from Radiation-induced Mitotic Catastrophe. Am. J. Physiol. Gastrointest Liver Physiol. 294(5):G1235-44.
Sureban, S.M., May, R., George, R.J., Dieckgraefe, B.K., Ramalingam, S., Natarajan, G., Anant, S., and Houchen, C.W. 2008. Knockdown of RNA binding protein musashi-1 (Msi-1) leads to tumor regression in vivo. Gastroenterology 134(5):1448-58.
Sureban, SM., May, R., Ramalingam, S., Subramaniam, D., Natarajan, G., Wyche, J., Anant, S. and Houchen, CW. 2009. Selective blockade of DCAMKL-1 results in tumor growth arrest by a let-7a microRNA dependent mechanism. Gastroenterology 137(2):649-59.
Pantazis, P., Varman, A., Simpson-Durand, C., Thorpe, J., Ramalingam, S., Subramaniam, D., Houchen, C.W., Anant, S., and Rama P Ramanujam. 2009. Turmeric and curcumin attenuate arsenic-induced angiogenesis in OVO. Alternative Therapies Health and Medicine, 16(2): 12-4.
Anant, S., Houchen, C.W., Pawar, V., and Ramalingam, S. 2010. Role of RNA-binding proteins in colorectal carcinogenesis. Current Colorectal Cancer Reports. 6(2), 68-73.
Subramaniam, D., Ramalingam, S., Houchen, C.W., Anant, S. 2010. Cancer Stem Cells: a novel paradigm for cancer prevention and treatment. Mini-Reviews in Medicinal Chemistry. 10(5), 359-71.