Research Assistant Professor
University of Kansas Medical Center, 2009
Embryonic developmental effects of in vitro manipulation techniques commonly used for in vivo fertilization
Over 4 million children have been born from artificial reproductive techniques (ARTs). To protect the health of children born by ARTs, we need to improve our understanding of gamete biology, embryology and the signaling pathways essential for normal healthy development. Our research focuses on tyrosine kinase signaling in the oocyte during maturation and fertilization. Several of these kinases are activated in cultured somatic cells in response to stress. While some of these kinases, such as FYN and FER are very highly expressed in oocytes, their response to in vitro culture stress of oocytes and embryos is unknown. The long-term goal of my research is to define the regulation and targets of these kinase signaling pathways in oocytes and to determine if these pathways function properly during clinical in vitro maturation and fertilization procedures.