Tsuneo Suzuki, M.D., Ph.D.

Professor Emeritus
Microbiology, Molecular Genetics and Immunology

M.D., University of Tokyo, 1957. Ph.D., University of Hokkaido, 1968

Selected Publications

  • Suzuki, T. 1991. Signal transduction mechanisms through Fcg receptors on the mouse macrophage surface. FASEB J.: 5:187-193.
  • Novotney, M., Chang, Z-L., Uchiyama, H. and Suzuki, T. 1991. Protein kinase C in tumoricidal activation of mouse macrophage cell lines. Biochemistry 30:5597-5604.
  • Chen, T-Y, Lei, M-G., Suzuki, T and Morrison, D.C. 1992. The macrophage receptor for bacterial lipopolysaccharide. In Macrophages and macrophage activation, eds. S. Gordon and S.W. Russell, Spring Verlag Inc., Heidelberg, p. 169-188.
  • Muroi, M. and Suzuki, T. 1993. Role of protein kinase A in activation of NF-kB proteins of a mouse macrophage-like cell line, J774. Cellular Signalling 5:289-298.
  • Muroi, M., Muroi, Y., Yamamoto, K., and Suzuki, T. 1993. Influence of 3' half site sequence of NF-kB motifs on the binding of lipopolysaccharide-activatable macrophage NF-kB proteins. J. Biol. Chem. 268:19534-19539.
  • Fujihara, M., Muroi, M., Ito, N., Muroi, Y. and Suzuki, T. 1993. Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774). J. Biol. Chem. 268:14898-14905.
  • Fujihara, M., N. Connolly, N. Ito and Suzuki, T. 1994. Properties of protein kinase isoforms (bII, e, and z) isoforms in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J. Immunol. 152:1898-1906.
  • Fujihara, M., Ito, N., Pace,J. L., Watanabe, Y., Russell, S. W., and Suzuki, T. 1994. Role of endogenous interferon- b in lipopolysaccharide-triggered activation of inducible nitric oxide synthase gene in a mouse macrophage cell line, J774. J. Biol. Chem. 269:12773-12778.
  • Muroi, M., Muroi, Y., and Suzuki, T. 1994. The binding of immobilized IgG2a to Fcg 2a receptor activates NF-kB via reactive oxygen intermediates and TNF-a. J. Biol. Chem. 269:30561-30568.
  • Muroi, M., Muroi, Y., Ito, N., Rice, N.R., and Suzuki, T. 1995. Effects of protease inhibitors on LPS-medicated activation of a mouse macrophage cell line (J774). J. Endotoxin Res. 2: 337-347.
  • Sato, K., Fujihara, M., Takahashi, T.,A., Yoo, Y. C., Hata, K., Tonooka, S., Suzuki, T., Sekiguchi, S., and Azuma, I. 1995. Endotoxin antagonism by a synthetic lipid A analogue, DT-5461, with low endotoxicity in human peripheral blood monocytes. Biochem. Biophys. Res. Commun. 216: 367-374.
  • Murphy, W., Muroi, M., Zhang, X., Suzuki, T., and Russell, S.W.1996. Both basal and enhancer kB elements are required for full induction of themouse inducible nitric oxide synthase gene. J. Endotoxin Res. 3:381-393.
  • Fujihara, M., Ikebuchi, K., Maekawa, T.L., Wakamoto, S., Ogiso, C, Ito, T.,Takahashi, T.A., Suzuki, T., and Sekiguchi, S. 1998. Lipopolysaccharide-induced desensitation of junB gene expression in a mouse macrophage-like cell line, P388D1. J. Immuol. 161:3659-3665.
  • Ito, N., Li, Y., Suzuki, T., Stechschulte, D.J., and Dileepan, K.N. 1998. Transient Degradation of NF-kB proteins in macrophages after interaction with mast cell granules. Mediators of Inflammation 7:397-407.
  • Nagai, E., Ogawa, T., Kielian, T., Ikubo, A., and Suzuki, T.. 1998. Irradiated tumor cells adenovirally engineered to secrete GM-CSF established anti-tumor immunity and eliminate pre-existing tumors in syngeneic mice. Cancer Immunol. Immunother. 47:72-80.
  • Suzuki, T. 1999. Role of NF-kB in macrophage activation. (review) In Endotoxin in Health and Disease, eds. by D. C. Morrison, H. Brade, S. Opal, and S. Vogel. Marcel Dekker, N.Y., N.Y.. pg. 502-520.
  • Kielian, T., Nagai, E., Ikubo, A., Rasmussen, C.A., and Suzuki, T. 1999. GM-CSF released by adenovirally-transduced CT26 cells leads to accumulation of dendritic cells at vaccination sites in vivo and local expression of MIP-1a. Cancer Immunol. and Immunother. 48:123-131.
  • Ikubo, A., Aoki, Y., Nagai, E., and Suzuki, T. 1999. Highly metastatic variant of a mouse colon carcinoma cell line, LM17 and its response to GM-CSF gene therapy. Clinical and Experimental Metastasis 17:849-855.
  • Fujihara, M., Wakamoto, S., Ito, T., Muroi, M., Suzuki, T., Ikeda, H., and Ikebuchi, K. 2000. Lipopolysaccharide-triggered desensitization of TNF-a mRNA expression involves lack of phosphorylation of Ikappa B alpha in a murine macrophage-like cell line, P388D1. J. Leukoc. Biol. 68:167-276.
  • Kusumoto, M., Umeda, S., Ikubo, A., Aoki, Y., Tawfik, O., Oben, R., Williamson, S., Jewell, W., and Suzuki, T. 2001. Phase 1 clinical trial of irradiated autologous melanoma cells adenovirally transduced withhuman GM-CSF gene. Cancer Immunol. Immunother. 50:373-381.
Last modified: Aug 26, 2011

Tsuneo Suzuki, M.D., Ph.D.
Professor Emeritus