Michael J. Parmely, Ph.D.
Microbiology, Molecular Genetics and Immunology
Ph.D., University of Iowa, 1974
The facultative intracellular bacterium Francisella tularensis is an organism that is only rarely associated with disease in human beings, but has gained a great deal of recent attention due to its potential use as a biowarfare agent. The organism is highly infectious by the pulmonary route, and a highly protective vaccine against the aerosol form of exposure does not currently exist. Recent studies have focused on gaining a more complete understanding of the pathogenesis of tularemia and defining suitable vaccine candidates.
Our current research is designed to:
- Identify immune correlates of protection against pulmonary and systemic tularemia
- Define the potential role of immune responses to the pathogen in the induction of host tissue damage
- Determine the unique features of immunity to the Type A subspecies of F. tularensis that distinguish them from the responses to less virulent subspecies
- Understand the basis for immune evasion by Type A F. tularensis strains
- Parmely, M.J., J.L. Fischer, and D.M. Pinson (2009) Programmed cell death and the pathogenesis of tissue injury induced by type A Francisella tularensis. FEMS Microbiol. Lett. in press. DOI:10.1111/j.1574-6968.2009.01791.x
- Wickstrum, J.R., S.M. Bokhari, J.L. Fischer, D.M. Pinson, H.-W. Ye, R.T. Horvat, and M.J. Parmely (2009) Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. Infect Immun. 77:4827-4836.
- Bokhari, S.M., K.-J. Kim, D.M. Pinson, J. Slusser, H.-W. Yeh, and M.J. Parmely (2008) NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with Francisella tularensis LVS. Infect. Immun. 76:1379-1389.
- Hong, K.-J., J.R. Wickstrum, H. Yeh and M.J. Parmely (2007) TLR2 controls the gamma interferon response to Francisella tularensis by mouse liver Lymphocytes. Infect. Immun.75:5338-45.
- Wickstrum, J.R., K.-J. Hong, S. Bokhari, N. Reed, N. McWilliams, R.T. Horvat and M.J. Parmely (2006) Coactivating signals for hepatic lymphocyte gamma interferon responses to Francisella tularensis. Infect. Immun. 75:1335-1342.
- Zhang, G, R.D. Nichols, M. Taniguchi, T. Nakayama and M.J. Parmely (2003) Gamma interferon production by hepatic NKT cells during Escherichia coli infections is resistant to the inhibitory effects of oxidative stress. Infect. Immun. 71:2468-2477.
- Parmely, M.J., F. Wang and D. Wright (2001) Gamma interferon prevents the inhibitory effects of oxidative stress on host responses to Escherichia coli infection. Infect. Immun. 69:2621-29.
Jul 05, 2016