Indranil Biswas, Ph.D.
Microbiology, Molecular Genetics and Immunology
Ph.D., University of Paris VII, Paris, France
Postdoctoral Fellow, NIDDK/NIH & Emory University
Publications: Click here
Gram-positive pathogens like Streptococci are the leading causes of human infections. These bacteria can cause diverse array of diseases such as pneumonia, meningitis, endocarditis, necrotizing faciitis to name a few. During the last two decades, gram-positive bacteria are becoming increasingly resistant to the available drugs, a very serious concern. These bacteria express a wide range of virulence factors that enable them to establish infections. Most of these virulence factors are either secreted or cell-wall associated. Several proteases play an important role in the expression, processing and maturation of these virulence factors. One of the main focuses of our laboratory is to study how various surface proteases affect virulence factor expression in streptococci. We are also studying how these proteases affect biofilm formation by various streptococci such as S. mutans.
A second project of the laboratory is to study the regulation of virulence gene expression in streptococci such as S. pyogenes and S. mutans. Expression of virulence factors is under complex regulatory networks and is not fully understood in streptococci. Our laboratory is interested in the mechanisms by which these bacteria regulate its virulence repertoire in response to host signals encountered during infection. Specifically, we have focused our studies on the molecular mechanisms of two-component signal transduction pathways that regulate a wide range of virulence genes in various streptococci. Our long term goal is to increase overall knowledge of gram-positive bacterial pathogenesis and to develop new treatment strategies.
Selected Recent Publications
Biswas S, Keightley A, Biswas I. Mol Oral Microbiol. Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB.
2019 Aug; 34 (4):153-167. doi: 10.1111/omi.12262. Epub 2019 Jun 7. PMID: 31056830
Shankar M, Hossain MS, Biswas I. Pleiotropic Regulation of Virulence Genes in Streptococcus mutans by the Conserved Small Protein SprV. J Bacteriol. 2017 Mar 28;199(8). pii: e00847-16. doi: 10.1128/JB.00847-16. PMID: 28167518
Jana B, Tao L, Biswas I. Strain-Dependent Recognition of a Unique Degradation Motif by ClpXP in Streptococcus mutans. mSphere. 2016 Dec 7;1(6). pii: e00287-16. PMID: 27981232
Vijayakumar S, Rajenderan S, Laishram S, Anandan S, Balaji V, Biswas I. Biofilm Formation and Motility Depend on the Nature of the Acinetobacter baumannii Clinical Isolates. Front Public Health. 2016 May 24; 4: 105. doi: 10.3389/fpubh.2016.00105. PMID: 27252939
Biswas S, Cao L, Kim A, Biswas I. SepM, a Streptococcal Protease Involved in Quorum Sensing, Displays Strict Substrate Specificity. J Bacteriol. 2015 Nov 9;198(3):436-47. doi: 10.1128/JB.00708-15. PMID: 26553848