Microbiology, Molecular Genetics and Immunology
Ph.D., University of Paris VII, Paris, France
Postdoctoral Fellow, NIDDK/NIH & Emory University
Publications: Click here
Gram-positive pathogens like Streptococci are the leading causes of human infections. These bacteria can cause diverse array of diseases such as pneumonia, meningitis, endocarditis, necrotizing faciitis to name a few. During the last two decades, gram-positive bacteria are becoming increasingly resistant to the available drugs, a very serious concern. These bacteria express a wide range of virulence factors that enable them to establish infections. Most of these virulence factors are either secreted or cell-wall associated. Several proteases play an important role in the expression, processing and maturation of these virulence factors. One of the main focuses of our laboratory is to study how various surface proteases affect virulence factor expression in streptococci. We are also studying how these proteases affect biofilm formation by various streptococci such as S. mutans.
A second project of the laboratory is to study the regulation of virulence gene expression in streptococci such as S. pyogenes and S. mutans. Expression of virulence factors is under complex regulatory networks and is not fully understood in streptococci. Our laboratory is interested in the mechanisms by which these bacteria regulate its virulence repertoire in response to host signals encountered during infection. Specifically, we have focused our studies on the molecular mechanisms of two-component signal transduction pathways that regulate a wide range of virulence genes in various streptococci. Our long term goal is to increase overall knowledge of gram-positive bacterial pathogenesis and to develop new treatment strategies.
Biswas I., Genetic tools for manipulating Acinetobacter baumannii genome: an overview. Journal of medical microbiology. 2015; 64(7):657-69. PubMed [journal]PMID: 25948809
Vijaykumar S., Balaji V., Biswas I., Complete Genome Sequence of Acinetobacter baumannii Strain B8300, Which Displays High Twitching Motility. Genome announcements. 2015; 3(4). PubMed [journal]PMID: 26294640 PMCID: PMC4543518
Vijaykumar S., Balaji V., Biswas I., Complete Genome Sequence of Acinetobacter baumannii Strain B8342, a Motility-Positive Clinical Isolate. Genome announcements. 2015; 3(4). PubMed [journal]PMID: 26294630 PMCID: PMC4543508
Balaji V., Rajenderan S., Anandan S, Biswas I., Genome Sequences of Two Multidrug-Resistant Acinetobacter baumannii Clinical Strains Isolated from Southern India. Genome announcements. 2015; 3(5). PubMed [journal]PMID: 26358595 PMCID: PMC4566177
Biswas S., Cao L., Kim A., Biswas I., SepM, a Streptococcal Protease Involved in Quorum Sensing, Displays Strict Substrate Specificity. Journal of bacteriology. 2015; 198(3):436-47. PubMed [journal]PMID: 26553848 PMCID: PMC4719462
Indranil Biswas, Ph.D.
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