Michael J. Parmely, Ph.D.

Professor and Chair

Microbiology, Molecular Genetics and Immunology

Ph.D., University of Iowa, 1974


Publications: Click here

Research Interests

The facultative intracellular bacterium Francisella tularensis is an organism that is only rarely associated with disease in human beings, but has gained a great deal of recent attention due to its potential use as a biowarfare agent. The organism is highly infectious by the pulmonary route, and a highly protective vaccine against the aerosol form of exposure does not currently exist. Recent studies have focused on gaining a more complete understanding of the pathogenesis of tularemia and defining suitable vaccine candidates.

Our current research is designed to:

  • Identify immune correlates of protection against pulmonary and systemic tularemia
  • Define the potential role of immune responses to the pathogen in the induction of host tissue damage
  • Determine the unique features of immunity to the Type A subspecies of F. tularensis that distinguish them from the responses to less virulent subspecies
  • Understand the basis for immune evasion by Type A F. tularensis strains

Selected Publications

  • Parmely, M.J., J.L. Fischer, and D.M. Pinson (2009) Programmed cell death and the pathogenesis of tissue injury induced by type A Francisella tularensis. FEMS Microbiol. Lett. in press. DOI:10.1111/j.1574-6968.2009.01791.x
  • Wickstrum, J.R., S.M. Bokhari, J.L. Fischer, D.M. Pinson, H.-W. Ye, R.T. Horvat, and M.J. Parmely (2009) Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. Infect Immun. 77:4827-4836.
  • Bokhari, S.M., K.-J. Kim, D.M. Pinson, J. Slusser, H.-W. Yeh, and M.J. Parmely (2008) NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with Francisella tularensis LVS. Infect. Immun. 76:1379-1389.
  • Hong, K.-J., J.R. Wickstrum, H. Yeh and M.J. Parmely (2007) TLR2 controls the gamma interferon response to Francisella tularensis by mouse liver Lymphocytes. Infect. Immun.75:5338-45.
  • Wickstrum, J.R., K.-J. Hong, S. Bokhari, N. Reed, N. McWilliams, R.T. Horvat and M.J. Parmely (2006) Coactivating signals for hepatic lymphocyte gamma interferon responses to Francisella tularensis. Infect. Immun. 75:1335-1342.
  • Zhang, G, R.D. Nichols, M. Taniguchi, T. Nakayama and M.J. Parmely (2003) Gamma interferon production by hepatic NKT cells during Escherichia coli infections is resistant to the inhibitory effects of oxidative stress. Infect. Immun. 71:2468-2477.
  • Parmely, M.J., F. Wang and D. Wright (2001) Gamma interferon prevents the inhibitory effects of oxidative stress on host responses to Escherichia coli infection. Infect. Immun. 69:2621-29.
Last modified: Dec 04, 2014

Michael J. Parmely, Ph.D.

Contact

Michael J. Parmely, Ph.D.
Professor and Chair

Office: 3003 Hixon
Lab: 4011 Orr Major

P: (913) 588-7053
(913) 588-7290
mparmely@kumc.edu

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