Michael J. Parmely, Ph.D.
Professor and Chair
Microbiology, Molecular Genetics and Immunology
Ph.D., University of Iowa, 1974
Office: 4016 Wahl Hall West | Lab: 4001/4031 Wahl Hall West
913-588-7053 | email
The facultative intracellular bacterium Francisella tularensis is an organism that is only rarely associated with disease in human beings, but has gained a great deal of recent attention due to its potential use as a biowarfare agent. The organism is highly infectious by the pulmonary route, and a highly protective vaccine against the aerosol form of exposure does not currently exist. Recent studies have focused on gaining a more complete understanding of the pathogenesis of tularemia and defining suitable vaccine candidates.
Our current research is designed to:
- Identify immune correlates of protection against pulmonary and systemic tularemia
- Define the potential role of immune responses to the pathogen in the induction of host tissue damage
- Determine the unique features of immunity to the Type A subspecies of F. tularensis that distinguish them from the responses to less virulent subspecies
- Understand the basis for immune evasion by Type A F. tularensis strains
- Parmely, M.J., J.L. Fischer, and D.M. Pinson (2009) Programmed cell death and the pathogenesis of tissue injury induced by type A Francisella tularensis. FEMS Microbiol. Lett. in press. DOI:10.1111/j.1574-6968.2009.01791.x
- Wickstrum, J.R., S.M. Bokhari, J.L. Fischer, D.M. Pinson, H.-W. Ye, R.T. Horvat, and M.J. Parmely (2009) Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice. Infect Immun. 77:4827-4836.
- Bokhari, S.M., K.-J. Kim, D.M. Pinson, J. Slusser, H.-W. Yeh, and M.J. Parmely (2008) NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with Francisella tularensis LVS. Infect. Immun. 76:1379-1389.
- Hong, K.-J., J.R. Wickstrum, H. Yeh and M.J. Parmely (2007) TLR2 controls the gamma interferon response to Francisella tularensis by mouse liver Lymphocytes. Infect. Immun.75:5338-45.
- Wickstrum, J.R., K.-J. Hong, S. Bokhari, N. Reed, N. McWilliams, R.T. Horvat and M.J. Parmely (2006) Coactivating signals for hepatic lymphocyte gamma interferon responses to Francisella tularensis. Infect. Immun. 75:1335-1342.
- Zhang, G, R.D. Nichols, M. Taniguchi, T. Nakayama and M.J. Parmely (2003) Gamma interferon production by hepatic NKT cells during Escherichia coli infections is resistant to the inhibitory effects of oxidative stress. Infect. Immun. 71:2468-2477.
- Parmely, M.J., F. Wang and D. Wright (2001) Gamma interferon prevents the inhibitory effects of oxidative stress on host responses to Escherichia coli infection. Infect. Immun. 69:2621-29.
May 13, 2014