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Infectious, Alcohol & Drug-Induced Liver Injury

HCV Mitochondria graphicLiver injury can be induced by a large number of infectious, toxic and metabolic events each of which have similarities and differences in the mechanisms by which they result in disease. The Liver Injury research group based primarily at KUMC in Kansas City studies mechanisms of diseases caused by viruses, alcohol and hepatotoxic drugs. Important areas of basic, translational and clinical research include Hepatitis C, Hepatitis B, alcoholic hepatitis and acetaminophen-induced liver injury.  This collaborative approach seeks to gain more insight on disease pathogenesis and create more effective approaches to the treatment and prevention of these conditions. 

Wen-Xing Ding, PhD
Autophagy and Apoptosis in liver injury and cancer therapy; redox signaling and mitochondrial damage

Severin Gudima, PhD
Molecular mechanism of Hepatitis B and Hepatitis Delta infection with emphasis on pathogenesis

Hartmut Jaeschke, PhD
Mechanisms of inflammatory liver injury and drug-induced hepatotoxicity; signaling mechanisms of apoptotic and necrotic cell death in liver cells

Steven Weinman, MD, PhD
Cellular pathogenesis of Hepatitis C

Last modified: Sep 28, 2018