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Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a major cause of liver-related death and the incidence of HCC is rising at an alarming rate. The development of HCC in a chronically diseased liver is a multistep process and although much is known about both the cellular changes that lead to HCC and the etiological agents responsible for the majority of HCC, the molecular pathogenesis of HCC is not well understood and effective prevention and treatment is not available for many patients. The Hepatocellular Carcinoma research group is jointly supported by the Liver Center and Cancer Center at KUMC and combines both translational and clinical collaborations to study the molecular mechanisms of HCC including HCC-induced genetic alterations, aberrant cellular growth, malignant transformation and inflammation-associated changes in cell growth control.

Udayan Apte, PhD
Termination of Liver Regeneration, Pathogenesis of Hepatocellular Carcinoma, Regulation of Cell Proliferation

Wen-Xing Ding, PhD
Autophagy and Apoptosis in liver injury and cancer therapy; Redox Signaling and Mitochondrial damage

Partha Kasturi, PhD
Role of ATP binding cassette (ABC) transporters in Biology and Medicine

Steven Weinman, MD, PhD
Cellular Pathogenesis of Hepatocellular Carcinoma

Stephen Williamson, MD
Division of Hematology/Oncology, Internal Medicine

Last modified: Sep 28, 2018