Selected Rowe Laboratory References

1. David, V., Martin, A.C., Hedge, A.M., Drezner, M.K., Rowe, P.S. (2010) ASARM peptides: PHEX-dependent & independent regulation of serum phosphate. Am J Physiol Renal Physiol. [Epub ahead of print] PMID: 21177780.
2. Boskey AL, Chiang P, Fermanis A, Brown J, Taleb H, David V, Rowe PS (2010) MEPE's Diverse Effects on Mineralization. Calcif Tissue Int 86(1): 42-6. PMCID: 2810528.
3. Boukpessi T, Gaucher C, Leger T, Salmon B, Le Faouder J, Willig C, Rowe PS, Garabedian M, Meilhac O, Chaussain C (2010). Abnormal presence of the matrix extracellular phosphoglycoprotein-derived acidic serine- and aspartate-rich motif peptide in human hypophosphatemic dentin. Am J Pathol 177(2):803-12. PMCID: 2913338.
4. Zhang P, Wang H, Rowe PS, Hu B, Wang Y. (2010) MEPE/OF45 as a new target for sensitizing human tumour cells to DNA damage inducers. Br J Cancer 102(5):862-6. PMCID: 2833259.
5. Liu S, Wang H, Wang X, Lu L, Gao N, Rowe PS, Hu B, and Wang Y (2009). MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1. Nucleic Acids Res Dec; 37(22):7447-54 PMID:19808933
6. David V, Martin A, Hedge AM, Rowe PS (2009). Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone & vascularization modulator. Endocrinology 2009; 150(9):4012-23. PMID: 19520780
7. Gaucher C, Boukpessi T, Septier D, Jehan F, Rowe PS, Garabédian M, Goldberg M, Chaussain-Miller C. Dentin noncollagenous matrix proteins in familial hypophosphatemic rickets. Cells Tissues Organs. 2009;189(1-4):219-23. PMID: 18701809
8. Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM, Rowe PS. Degradation of MEPE, DMP1 & release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology. 2008 Apr;149(4):1757-72. PMID: 18162525
9. Yuan B, Takaiwa M, Clemens TL, Feng JQ, Kumar R, Rowe PS, Xie Y, Drezner MK 2008 Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest. 118(2):722-34. ; PMID 18172553
10. Harris SE, Gluhak-Heinrich J, Harris MA, Yang W, Bonewald LF, Riha D, Rowe PS, Robling AG, Turner CH, Feng JQ, McKee MD, Nicollela D. DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix. J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):313-5. PMID: 18094489
11. Rowe PS*, Liu S*, Vierthaler L, Zhou J, Quarles LD 2007 Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity. J Endocrinol 192:261-267 (*PR and SL joint first authors)
12. Rowe PS, Matsumoto N, Jo OD, Shih RN, Oconnor J, Roudier MP, Bain S, Liu S, Harrison J, Yanagawa N 2006 Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin. Bone 39:773-786
13. Rowe PS, Garrett IR, Schwarz PM, Carnes DL, Lafer EM, Mundy GR, Gutierrez GE 2005 Surface Plasmon Resonance (SPR) confirms MEPE binds to PHEX via the MEPE-ASARM-motif: A model for impaired mineralization in X-linked rickets (HYP). Bone 36:33-46
14. Rowe PS, Kumagai Y, Gutierrez G, Garrett IR, Blacher R, Rosen D, Cundy J, Navvab S, Chen D, Drezner MK, Quarles LD, Mundy GR 2004 MEPE has the properties of an osteoblastic Phosphatonin and Minhibin. Bone 34:303-319
15. Rowe PS 2004 The wrickkened-pathways of FGF23, MEPE and PHEX. Crit Rev Oral Biol Med 15:264-281
16. Bresler D, Bruder J, Mohnike KL, Fraser D, Rowe PS 2004 Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets. J Endocrinol 183:R1-9
17. Syed BA, Beaumont NJ, Patel A, Naylor CE, Bayele HK, Joannou CL, Rowe PS, Evans RW, Srai SK 2002 Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin. Protein Eng 15:205-214.
18. Guo R, Rowe PS, Liu S, Simpson LG, Xiao ZS, Quarles LD 2002 Inhibition of MEPE cleavage by Phex. Biochem Biophys Res Commun 297:38-45.
19. Rowe PS, de Zoysa P, Dong R, Wang H, White K, Econs M, Oudet C 2000 MEPE, a new gene expressed in bone-marrow and tumours causing osteomalacia. Genomics 67 (1):54-68
20. Rowe PS 2000 Finding Mutations in Disease Genes. In: Econs MJ ed. Genetics of Osteoporosis and Metabolic Bone Disease. 1 ed. Totowa New Jersey: Humana Press Inc; 431-446
21. Rowe PS 2000 The molecular background to hypophosphataemic rickets. Arch Dis Child 83:192-194
22. Popowska E, Pronicka E, Sulek A, Jurkiewicz D, Rowe P, Rowinska E, Krajewska-Walasek M 2000 X-linked hypophosphatemia in Polish patients. 1. Mutations in the PHEX gene. J Appl Genet 41:293-302
23. Filisetti D, Osterman G, von Bredow M, Strom T, Filler G, Ehrich J, Pannetier S, Garnier J, Rowe PSN, Francis F, Julienne A, Hanauer A, Econs M, Oudet C 1999 Non random distribution of mutations in the PHEX gene, and under-detected missense mutations at non conserved residues. European Journal of Human Genetics 7:615-619
24. Rowe PS 1998 X-linked rickets and tumour osteomalacia: PHEX and the missing link. Clinical and Experimental Nephrology 2(3):183-193
25. Rowe PS 1998 The role of the PHEX gene (PEX), in families with X-linked hypophosphataemic rickets. Current Opinion in Nephrology & Hypertension 7(4):367-376
26. Econs MJ, Friedman NE, Rowe PS, Speer MC, Francis F, Strom TM, Oudet C, Smith JA, Ninomiya JT, Lee BE, Bergen H 1998 A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets. JClinEndocrinolMetab 83:3459-3462
27. Blair HJ, Uwechue IC, Barsh GS, Rowe PS, Boyd Y 1998 An integrated genetic and man-mouse comparative map of the DXHXS674-Pdha1 region of the mouse X chromosome. Genomics 48:128-131
28. Rowe PS, Oudet C, Francis F, Sinding C, Pannetier S, Econs MJ, Strom TM, Meitinger T, Garabedian M, David A, Macher M-A, Questiaux E, Popowska E, Pronicka E, Read AP, Mokrzycki A, Glorieux FH, Drezner MK, Hanauer A, Lehrach H, Goulding J, O'Riordan JLH 1997 Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP). Hum Mol Genet 6:539-549
29. Rowe PS 1997 The PEX gene: its role in X-linked rickets, osteomalacia, and bone mineral metabolism. Exp Nephrol 5:355-363
30. Francis F, Strom TM, Hennig S, Boeddrich A, Lorenz B, Brandau O, Mohnike KL, Cagnoli M, Steffens C, Klages S, Borzym K, Pohl T, Oudet C, Econs MJ, Rowe PS, Reinhardt R, Meitinger T, Lehrach H 1997 Genomic organisation of the human PEX gene mutated in X-linked dominant hypophosphataemic rickets. Gen Res 7(6):573-585
31. Rowe PS, Ong A, Cockerill F, Goulding J, Hewison M 1996 Candidate 56 and 58 kDa protein(s) responsible for mediating the renal defects in oncogenic hypophosphataemic osteomalacia. Bone 18(2):159-169
32. Rowe PS, Goulding JN, Francis F, Oudet C, Econs MJ, Hanauer A, Lehrach H, Read AP, Mountford RC, Summerfield T, Weissenbach J, Fraser W, Drezner MK, Davies KE, Oriordan JLH 1996 The gene for X-linked hypophosphataemic rickets maps to a 200- 300 kb region in Xp22.1, and is located on a single YAC containing a putative vitamin D response element (VDRE). Human Genetics 97:345-352
33. Gillett GT, Fox MF, Rowe PS, Casimir CM, Povey S 1996 Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. AnnHumGenet 60(3):201-211
34. HYP-consortium, Francis F, Hennig S, Korn b, Reinhardt R, de Jong D, Poustka A, Lehrach H, Rowe PS, Goulding JN, Summerfield T, Mountford RC, Read AP, Popowska E, Pronicka E, Davies KE, O'Riordan JLH, Econs MJ, Nesbitt T, Drezner MK, Oudet C, Pannetier S, Hanauer A, Strom TM, Meindl A, Lorenz B, Cagnoli M, Mohnike KL, Murken J, Meitinger T 1995 A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. Nat Genet 11:130-136
35. Rowe PS, Goulding J, Read A, Lehrach H, Francis F, Hanauer A, Oudet C, Biancalana V, Kooh SW, Davies KE, Oriordan JLH 1994 Refining the Genetic-Map for the Region Flanking the X-Linked Hypophosphatemic Rickets Locus (Xp22.1-22.2). Human Genetics 93:291-294
36. Rowe PS, Francis F, Goulding J 1994 Rapid isolation of DNA sequences flanking microsatellite repeats. NucleicAcidsRes 22(23):5135-5136
37. Rowe PS 1994 Molecular Biology of Hypophosphataemic Rickets and Oncogenic Osteomalacia. HumGenet 94:(5):457-467.
38. Francis F, Rowe PS, Econs MJ, See CG, Benham F, O'Riordan JL, Drezner MK, Hamvas RM, Lehrach H 1994 A YAC contig spanning the hypophosphatemic rickets disease gene (HYP) candidate region. Genomics 21:229-237
39. Econs MJ, Rowe PS, Francis F, Barker DF, Speer MC, Norman M, Fain PR, Weissenbach J, Read A, Davis KE, et al 1994 Fine structure mapping of the human X-linked hypophosphatemic rickets gene locus. JClinEndocrinolMetab 79:1351-1354
40. Econs MJ, Francis F, Rowe PS, Speer MC, O'Riordan JLH, Lehrach H, Becker PA 1994 Dinucleotide repeat polymorphism at the DXS1683 locus. HumMolGenet 3(4):680
41. Biancalana V, Trivier E, Weber C, Weissenbach J, Rowe PS, Oriordan JLH, Partington MW, Heyberger S, Oudet C, Hanauer A 1994 Construction of a High-Resolution Linkage Map for Xp22.1-P22.2 and Refinement of the Genetic Localization of the Coffin-Lowry Syndrome Gene. Genomics 22:617-625
42. Rowe PS, Goulding J, Read AP, Mountford RC, Hanauer A, Oudet C, Whyte MP, Meier-Ewert S, Lehrach H, Davies KE, O'Riordan JLH 1993 New markers for linkage analysis of hypophosphataemic rickets. HumGenet 91:571-575
43. Rowe PS, Read AP, Mountford RC, Benham F, Kruse TA, Camarino G, Davies KE, O'Riordan JLH 1992 Three DNA markers for hypophosphataemic rickets. HumGenet 89:539-542
44. Benham F and Rowe PS 1992 Use of Alu-PCR to characterize hybrids containing multiple fragments and to generate new Xp21.3-p22.2 markers. Genomics 12:368-376
45. Casimir CM, Bu Ghanim HN, Rodaway AR, Bentley DL, Rowe P, Segal AW 1991 Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat. ProcNatlAcadSciUSA 88:2753-2757
46. Teahan C, Rowe P, Parker P, Totty N, Segal AW 1987 The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245. Nature 327:720-721