Shui Q. Ye, M.D., Ph.D.

Professor and William R. Brown/Missouri Endowed Chair in Medical Genetics and Molecular Medicine
Director, Division of Experimental and Translational Genetics
Director, Core of Genetic Research
Dept. of Pediatrics and Dept. of Biomedical and Health Informatics, Children's Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine

Ph.D., University of Chicago, 1993
M.D., Wuhan University School of Medicine, China, 1982
Postdoctoral, Oklahoma Medical Research Foundation, 1985-1988


Our current and growing research interests cover three major areas: 1. To investigate Nicotinamide Phosphoribosyltransferase (NAMPT, also called pre-B-cell colony enhancing factor or visfatin) in the human physiology and pathology such as role of NAMPT in embryonic and organ development, acute respiratory distress syndrome, cancer, drug induced liver toxicity, stroke; 2. To dissect genetic components of complex human diseases such as coronary artery, chronic kidney disease, arthritis using omics technologies; 3. To apply Translational Bioinformatics to leverage omics data to make new biological discoveries and gain new unifying global biological insights, which may lead to the development of new diagnostic and therapeutic targets for human diseases.

Selected Publications

Grigoryev DN, Dalal J, Becker ML, Ye SQ. Combined meta-analysis of systemic effects of allogeneic stem cell transplantation and systemic sclerosis. BMC Hematol. 2014; 14(1):7.

Cheranova D, Gibson M, Chaudhary S, Zhang LQ, Heruth DP, Grigoryev DN, Ye SQRNA-seq Analysis of Transcriptomes in Thrombin-treated and Control Human Pulmonary Microvascular Endothelial Cells. J Vis Exp. 2013; (72): e4393.

Heruth DP, Gibson M, Grigoryev DN,  Zhang LQ, Ye SQRNA-seq analysis of synovial fibroblasts brings   new insights into rheumatoid arthritis.  Cell Biosci. 2012; 2(1):43.

Zhang LQ, Cheranova D, Gibson M, Ding S, Heruth DP, Fang D, Ye SQ.  RNA-seq reveals novel transcriptome of genes and their isoforms in human pulmonary microvascular endothelial cells treated with Thrombin. PLoS ONE 2012; 7(2): e31229.

Lee MW Jr, Sevryugina YV, Khan A, Ye SQ. Carboranes Increase the Potency of Small Molecule Inhibitors of Nicotinamide Phosphoribosyltranferase.J Med Chem. 2012; 55(16):7290-4.

Cheranova D, Gibson M, Kibiryeva N, Zhang LQ, Ye SQ.  Pleiotropic functions of PBEF revealed by transcriptomics of human pulmonary microvascular endothelial cells treated with PBEFsiRNA. Genes Cells. 2012; 17(5):420-30.

Zhang W, Xie Y,  Wang T, Li H,  Zhang LQ, Ye SQ, Ding S.  Neuronal Protective Role of PBEF in a Mouse Model of Cerebral Ischemia. J Cereb Blood Flow Metab. 2010; 30(12):1962-71.

Liu P, Li H, Cepeda J, Xia Y, Kempf JA, Ye H, Zhang LQ, Ye SQ.  Regulation of inflammatory cytokine expression in pulmonary epithelial cells by pre-B-cell colony enhancing factor via a nonenzymatic and AP-1 dependent mechanism.  J Biol Chem.  2009; 284(40):27344-51.

Ye SQ, Simon B, Maloney JP, Zambelli-Weiner A, Gao L,  Grant A, Easley RB, McVerry B, Tuder RM, Standiford T, Brower R, Barnes K, Garcia JGN. Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med. 2005; 171 (4): 361-370.

Irizarry RA, Warren D, Spencer F, Kim IF, Biswal S, Frank BC, Gabrielson E, Garcia JG, Geoghegan J, Germino G, Griffin C, Hilmer SC, Hoffman E, Jedlicka AE, Kawasaki E, Martinez-Murillo F, Morsberger L, Lee H, Petersen D, Quackenbush J, Scott A, Wilson M, Yang Y, Ye SQ, Yu W. Multiple Lab Comparison of Microarray Platforms. Nat Methods. 2005; 2(5):345-350.

 

Last modified: Jun 16, 2014

Contact

Shui Q. Ye, M.D., Ph.D.
Professor and William R. Brown/Missouri Endowed Chair in Medical Genetics and Molecular Medicine
Director, Division of Experimental and Translational Genetics
Director, Core of Genetic Research

sqye@cmh.edu

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