Sacha A. Krieg, M.D., Ph.D., FACOG

Assistant Professor
Director of the Recurrent Pregnancy Loss Program
Division of Reproductive Endocrinology and Infertility
Department of Obstetrics and Gynecology

Ph.D., University of Illinois at Urbana-Champaign, 2001
M.D., University of Illinois at Urbana-Champaign, 2003
Residency, Stanford Hospital and Clinics, 2003-2007
Fellowship, Stanford Hospital and Clinics, 2007-2010


skrieg@kumc.edu

Pregnancy loss is the most common complication of human pregnancy, impacting approximately 10-15% of all human conceptions. While for most fertile couples miscarriage is a sporadic event, approximately 1-5% of fertile couples suffer from recurrent pregnancy loss (RPL), having a profound impact on their fertility and emotional well being.  Although RPL has been attributed to several hematologic, anatomic, hormonal and genetic defects, more than 50% of cases remain classified as having unknown etiology.   My research interests focus on this subgroup of patients, in particular patients who are at risk for having endometrial causes of early pregnancy loss.  To date we have investigated decidual contributions to recurrent miscarriage via microarray analysis.  We are beginning to further characterize dysregulated gene products both at a molecular level and in an in vitro model of trophoblastic invasion.

Selected Publications

Krieg SA, Fan X, Hong Y, Sang QX, Giaccia A, Westphal LM, Lathi RB, Krieg AJ, Nayak NR. Global alternation in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Mol Hum Reprod. 2012 Sep:18(9):442-50.

Dwyer BK, Krieg S, Balise R, Carroll IR, Chueh J, Nayak N, Druzin M. Variable  expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia. J Matern Fetal Neonatal Med. 2010 Jul;23(7):705-11.

Krieg SA, Lathi RB, Behr B, Westphal LM. Normal pregnancy after tetraploid karyotype on trophectoderm biopsy. Fertil Steril. 2009 Sep;92(3):1169.e9-1169.e10.

Fan X, Krieg S, Kuo CJ, Wiegand SJ, Rabinovitch M, Druzin ML, Brenner RM, Giudice LC, Nayak NR. VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J. 2008 Oct;22(10):3571-80.

Krieg SA, Henne MB, Westphal LM. Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies. Fertil Steril. 2008 Jul;90(1):65-70.

Krieg AJ, Krieg SA, Ahn BS, Shapiro DJ. Interplay between estrogen response element sequence and ligands controls in vivo binding of estrogen receptor to regulated genes. J Biol Chem. 2004 Feb 6;279(6):5025-34.

Last modified: Dec 28, 2012

Sacha A. Krieg M.D., Ph.D., FACOG

Contact

Sacha A. Krieg, M.D., Ph.D., FACOG
Assistant Professor
Director of the Recurrent Pregnancy Loss Program
Division of Reproductive Endocrinology and Infertility

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