Russell H. Swerdlow, M.D.

Professor
Director, University of Kansas Alzheimer's Disease Center
Director, University of Kansas Medical Center Neurodegenerative Disease Program
Departments of Neurology, Molecular and Integrative Physiology, Biochemistry and Molecular Biology

M.D., New York University School of Medicine, 1991
Fellowship, University of Virginia, 1995-1997

rswerdlow@kumc.edu

Dr. Swerdlow studies brain energy metabolism and the role brain energy metabolism plays in Alzheimer's disease and other neurodegenerative diseases.  He was the first to propose using ketone bodies to improve brain energy metabolism in Alzheimer's disease patients, presaging the development of this now-utilized Alzheimer's disease treatment approach.  His laboratory is actively working on new ways to manipulate brain energy metabolism.  The goal of this work is to create new and effective treatments that will hopefully help people with Alzheimer's disease. 

Swerdlow RH, The neurodegenerative mitochondriopathies. J Alz Dis 2009:17-737-751.

Esteves AR, Lu J, Rodova M, Onyango I, E Lezi, Dubinsky R, Lyons KE, Pahwa R, Burns JM, Cardoso SM, Swerdlow RH, Mitochondrial respiration and respiration associated proteins in cell lines created through Parkinson's subject mitochondrial transfer. J Neurochem 2010:113:674-682.

Lu J, Wang KX, Rodova M, Esteves R, Berry D, E Lezi, Crafter A, Barrett M, Cardoso SM, Onyango I, Parker WD, Fontes J, Burns JM, Swerdlow RH.  Polymorphic variation in cytochrome oxidase subunit genes. JAD 2010;21:141-154.

Swerdlow RH, Burns JM, Khan SM.  The Alzheimer's disease Mitochondrial Cascade Hypothesis.  JAD 2010;20 Suppl 2:S265-279.

Lu J, E L, Wang WF, Frontera J, Zhu H, Wang WT, Lee SP, Choi IY, Brooks WM, Burns JM, Aires D, Swerdlow RH.  Alternate day fasting impacts the brain insulin signaling pathway of young adult male C57BL/6 mice.  J Neurochem 2011;117:

Swerdlow RH.  Role and Treatment of Mitochondrial DNA-Related Mitochondrial Dysfunction in Sporadic Neurodegenerative Diseases. Curr Pharm Des 2011;17:3356-3373.

Mosconi L, de Leon M, Murray J, E Lezi, Lu J, Javier E, McHugh P, Swerdlow RH.  Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's.  JAD 2011;27:483-490.

Swerdlow RH.  Brain aging, Alzheimer's disease, and mitochondria. Biochim Biophys Acta, 2011;1812:1630-1639.

Aires D, Rockwell G, Wang T, Frontera J, Wick J, Wang W, Tonkovic-Capin M, Lu J, E   L, Zhu H, Swerdlow RH.  Potentiation of dieterary restriction-induced lifespan extension by polyphenols. Biochim Biophys Acta, in press.