Division of Animal Sciences, University of Missouri-Columbia
Ph.D., University of Florida, 2003
Postdoctoral, University of Pennsylvania, 2004-2007
Assisted reproduction in humans and animals has been linked to inappropriate control of the epigenome in gametes and preimplantation embryos that results in adverse consequences during fetal and postnatal development. Commonly used assisted reproductive technology (ART) procedures include: ovarian hyperstimulation (superovulation), in vitro maturation, in vitro fertilization, intra-cytoplasmic sperm injection, embryo culture, and embryo transfer. The research conducted in my laboratory aims at understanding the mechanisms whereby manipulations of mammalian gametes and embryos result in alterations of the epigenome. The long term goal of our research is to provide recommendations in order to decrease the negative side effects associated with ART.
Rivera RM and Ross J . 2013. Epigenetics in fertilization and preimplantation embryo development. Special issue on Systems Biology and Reproductive Biology . Prog Biophys Mol Biol . 113(3):423 - 32.
Rivera RM * . and Bennett L. 2010. Epigenetics in humans: an overview. Curr Opin Endocrinol Diabetes Obes 17:493 - 499.
Huffman SR, Almamun, Md, Rivera RM. 2012 . Methods in Molecular Biology, Imprinting Protocols, Chapter 13, Isolation of RNA and D NA from single preimplantation embryos and small number of mammalian oocytes for imprinting studies. Methods Mol Biol. 925:201 - 209.
La Spina FA, Romanato M, Brugo - Olmedo S, De Vincentiis S, Julianelli V, Rivera RM , Buffone, MG. Heterogeneous distribution of histone methylation in mature human sperm Journal of Assisted Reproduction and Genetics. 2013 . J Assist Reprod Genet . 2013 Nov 13.
Schenewerk Angela L, Ramírez Francisco Foote, Christopher Ji, Tieming, Martínez - Lemus, Luis A, Rivera Rocío Melissa . 2013. Effects of the Use of Assisted Reproduction and High Caloric Diet Consumption on Body Weight and Cardiovascular Health of Juvenile Mouse Offspring. Reproduction 147(1):111 - 23.
Negrón - Pérez VM, Echevarría FD, Huffman SR, and Rivera RM. 2013. Determination of Allelic Expression of H19 in Pre - and Peri - Implantation Mouse Embryos . Biol Reprod . 88(4):97.
Robbins KM, Chen Z, Wells KD, and Rivera RM. 2012. Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine. J Biomed Sci . 2012 Nov 15;19:95.
Zhao MT, Rivera RM , Prather RS . 2013. Locus - Specific DNA Methylation Reprogramming During Early Porcine Embryogenesis. Biol Reprod. 88(2):48.
Rivera RM , Stein PS, Weaver JR, Mager J, Schultz RM, Bartolomei MS. 2008. Manipulations of mouse embryos prior to implantation res ult in aberrant expression of imprinted genes on day 9.5 of development . Human Molecular Genetics 17:1 - 14.
Rivera RM, Dahlgren GM, de Castro e Paula LA, Kennedy RT, Hansen PJ. 2004. Actions of thermal stress in two - cell bovine embryos: Oxygen metabolism, glutathione and ATP content, and the time - course of development. Reproduction 128:33 - 42.
Rocio M. Rivera, Ph.D.