Rajasingh Johnson, M.Phil., Ph.D., HCLD

Assistant Professor
Dept. of Internal Medicine, Division of Cardiovascular Diseases
Member, Center for Epigenetics and Stem Cell Biology

M.Phil, Presidency College, Chennai, India, 1988
Ph.D., SGPGI Lucknow and Avadh University, Faizabad, India, 1998
Postdoctoral, Vanderbilt University, Nashville and Tufts University, Boston, 2004-2007


rjohnson9@kumc.edu

Overview of Research Interests:

  • Reprogramming of somatic cells to generate induced pluripotent (iPS cells) or multipotent stem cells and its therapeutic potential in regenerative medicines;
  • Study the mechanisms of reprogramming by histone deacetylation and DNA methylation;
  • Use of embryonic and adult stem cells in cardiovascular and lung vascular repair and regeneration.

Selected Publications

Rajasingh S, Thangavel J, Czirok A, Samanta S, Roby KF, Dawn B, Rajasingh J. Generation of Functional Cardiomyocytes from Efficiently Generated Human iPSCs and a Novel Method of Measuring Contractility. PLoS One. 2015 Aug 3;10(8):e0134093. doi: 10.1371/journal.pone.0134093. eCollection 2015. PubMed .

Thangavel J, Samanta S, Rajasingh S, Barani B, Xuan YT, Dawn B, Rajasingh J. Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. J Cell Sci. 2015 Aug 15;128(16):3094-105. doi: 10.1242/jcs.170258. Epub 2015 Jun 26. .

Rajasingh J. Rajasingh J. The many facets of RNA binding protein HuR. Trends in Cardiovascular Medicine. (2015) Mar 31. pii: S1050-1738(15)00110-3.

Thangavel J, Malik AB, Elias HK, Rajasingh S, Simpson AD, Sundivakkam PK, Vogel SM, Xuan YT, Dawn B, Rajasingh J. Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury. Am J Pathol. 2014 Aug;184(8):2237-49.

Rajasingh J, Jayakumar T, Siddiqui MR, Gomes I, Gao XP, Kishore R, Malik AB. Improvement of Cardiac Function in Mouse Myocardial Infarction after Transplantation of Epigenetically-Modified Bone Marrow Progenitor Cells. PLoS One. 2011;6(7):e22550.

Siddiqui MR, Komarova YA, Vogel SM, Gao XP, Bonini MG, Rajasingh J,  Zhao YY, Brovkovych V, Malik AB. Caveolin-1-eNOS Signaling Regulates p190RhoGAP-A Nitration and Endothelial Permeability. J. Cell Biology 193 (5): 841-850, 2011.

Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R. IL-10 attenuates inflammation mediated left ventricular remodeling after myocardial infarction via activation of STAT-3 and suppression of HuR. Circulation Research 104:e9-18, 2009.

Suriano R, Chaudhuri D, Rajasingh J, Lambers E, Kishore R, Tiwari RK. 17-b-estradiol mobilizes bone marrow endothelial progenitor cells to tumors. Cancer Research 66 (15), 6038-42, 2008.

Rajasingh J, Lambers E, Hamada H, Bord E, Thorne T, Goukassian I, Krishnamurthy P, Rosen KM, Ahluwalia D, Zhu Y, Qin G, Losordo DW, Kishore R. Cell-free Embryonic Stem Cell Extract-mediated derivation of Multipotent Stem Cells from NH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair. Circulation Research 102(11):e107-17, 2008.

Last modified: Apr 21, 2016

Contact

Rajasingh Johnson, M.Phil., Ph.D., HCLD
Assistant Professor
Dept. of Internal Medicine, Division of Cardiovascular Diseases

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