Rajasingh Johnson, M.Phil., Ph.D., HCLD

Assistant Professor
Dept. of Internal Medicine, Division of Cardiovascular Diseases
Member, Center for Epigenetics and Stem Cell Biology

M.Phil, Presidency College, Chennai, India, 1988
Ph.D., SGPGI Lucknow and Avadh University, Faizabad, India, 1998
Postdoctoral, Vanderbilt University, Nashville and Tufts University, Boston, 2004-2007


rjohnson9@kumc.edu

Overview of Research Interests:

  • Reprogramming of somatic cells to generate induced pluripotent (iPS cells) or multipotent stem cells and its therapeutic potential in regenerative medicines;
  • Study the mechanisms of reprogramming by histone deacetylation and DNA methylation;
  • Use of embryonic and adult stem cells in cardiovascular and lung vascular repair and regeneration.

Selected Publications

Rajasingh J, Jayakumar T, Siddiqui MR, Gomes I, Gao XP, Kishore R, Malik AB. Improvement of Cardiac Function in Mouse Myocardial Infarction after Transplantation of Epigenetically-Modified Bone Marrow Progenitor Cells. PLoS One. 2011;6(7):e22550.

Siddiqui MR, Komarova YA, Vogel SM, Gao XP, Bonini MG, Rajasingh J,  Zhao YY, Brovkovych V, Malik AB. Caveolin-1-eNOS Signaling Regulates p190RhoGAP-A Nitration and Endothelial Permeability. J. Cell Biology 193 (5): 841-850, 2011.

Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo DW, Kishore R. IL-10 attenuates inflammation mediated left ventricular remodeling after myocardial infarction via activation of STAT-3 and suppression of HuR. Circulation Research 104:e9-18, 2009.

Suriano R, Chaudhuri D, Rajasingh J, Lambers E, Kishore R, Tiwari RK. 17-b-estradiol mobilizes bone marrow endothelial progenitor cells to tumors. Cancer Research 66 (15), 6038-42, 2008.

Rajasingh J, Lambers E, Hamada H, Bord E, Thorne T, Goukassian I, Krishnamurthy P, Rosen KM, Ahluwalia D, Zhu Y, Qin G, Losordo DW, Kishore R. Cell-free Embryonic Stem Cell Extract-mediated derivation of Multipotent Stem Cells from NH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair. Circulation Research 102(11):e107-17, 2008.

Rajasingh J, Hamada H, Qin G, Bord E, Silver M, Mehta S, Goukassain D, Losordo DW, Kishore R. STAT3-dependent mouse Embryonic Stem Cell Differentiation into Cardiomyocytes: Analysis of Molecular Signaling and Therapeutic Efficacy of Cardiomyocyte Pre-committed mES in a Mouse Model of myocardial Infarction Circulation Research 101:910-918. 2007

Rajasingh J, Bord E, Qin G, Ii M, Silver M, Hamada H, Goukassian D, Zhu Y, Losordo DW, Kishore R. Enhanced Voluntary Alcohol Consumption Following Estrogen Supplementation Negates Estrogen- mediated Vascular Repair in Ovariectomized Mice. Endocrinology 148(8):3618-24, 2007

Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, Qin G, Goukassian D, Zhu Y, Losordo DW, Kishore R. IL-10-induced TNF-alpha mRNA Destabilization is Mediated via IL-10 Suppression of p38 MAP Kinase Activation and Inhibition of HuR Expression FASEB J. 12:2112-2124, 2006

Rajasingh J and Bright JJ. 15-Deoxy-Δ12,14-Prostaglandin J2 Regulates Leukemia Inhibitory Factor Signaling through JAK-STAT Pathway in Mouse Embryonic Stem Cell. Experimental Cell Research 312: 2538-2546, 2006.

Last modified: Feb 24, 2014

Contact

Rajasingh Johnson, M.Phil., Ph.D., HCLD
Assistant Professor
Dept. of Internal Medicine, Division of Cardiovascular Diseases

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