Vice Chancellor for Research
Department of Molecular and Integrative Physiology
Ph.D., Lousiana State University, 1975
Postdoctoral, University of Kansas Medical Center, 1975- 1977
My research program has several different projects related to ovarian function. The first project investigates the molecular mechanisms by which tumor necrosis factor (TNF) affects ovarian function. Our approaches to studying these problems are multifold. We are using in vitro approaches to determine the signal transduction mechanisms used by TNF in altering gene expression and signaling. For example, TNF inhibits multiple steps in the cAMP signaling cascade including protein kinase A and transcription factors. The second project investigates the role of Src tyrosine kinase in ovarian follicular development and steroidogenesis. Src regulates the activity of phosphodiesterase, a major regulator of ovarian cAMP, which is the second messenger of most of the gonadotropins. This project uses a mouse model of ovarian cancer to determine factors related to early onset and progression of this cancer as well as determine biomarkers for early detection.
Son DS, Terranova PF, Roby KF. Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform. Endocrinology. 2010 Jul;151(7):3407-19.
Yang J, Takahashi Y, Cheng E, Liu J, Terranova PF, Zhao B, Thrasher JB, Wang HG, Li B. GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death. J Cell Sci. 2010 Mar 15;123(Pt 6):861-70.
Sun A, Tang J, Terranova PF, Zhang X, Thrasher JB, Li B. Adeno-associated virus-delivered short hairpin-structured RNA for androgen receptor gene silencing induces tumor eradication of prostate cancer xenografts in nude mice: a preclinical study. Int J Cancer. 2010 Feb 1;126(3):764-74.
Chaturvedi G, Arai K, Terranova PF, Roby KF. The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion. Mol Cell Biochem. 2008 Nov;318(1-2):191-200.
Roby KF, Niu F, Rajewski RA, Decedue C, Subramaniam B, Terranova PF. Syngeneic mouse model of epithelial ovarian cancer: effects of nanoparticulate paclitaxel, Nanotax. Adv Exp Med Biol. 2008;622:169-81.
Barnett KR, Tomic D, Gupta RK, Babus JK, Roby KF, Terranova PF, Flaws JA. The aryl hydrocarbon receptor is required for normal gonadotropin responsiveness in the mouse ovary. Toxicol Appl Pharmacol. 2007 Aug 15;223(1):66-72.
Greenfeld CR, Roby KF, Pepling ME, Babus JK, Terranova PF, Flaws JA. Tumor necrosis factor (TNF) receptor type 2 is an important mediator of TNF alpha function in the mouse ovary. Biol Reprod. 2007 Feb;76(2):224-31.
Shanmugam I, Cheng G, Terranova PF, Thrasher JB, Thomas CP, Li B. Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival. Cell Death Differ. 2007 Dec;14(12):2085-94.
Zhu Q, Youn H, Tang J, Tawfik O, Dennis K, Terranova PF, Du J, Raynal P, Thrasher JB, Li B. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene. 2008 Jul 31;27(33):4569-79.
Paul F. Terranova, Ph.D.
Vice Chancellor for Research