Professor and Chair
Department of Pharmacology and Toxicology - University of Kansas, Lawrence
PhD, University of Louisville, 1985
Postdoctoral, John Hopkins University School of Medicince, 1985-1988
Our research is directed toward an understanding of the mechanisms involved in neuropsychiatric and neurodegenerative disorders. Currently, we are examining the mechanisms regulating adaptations in serotonin receptor signaling as new targets for therapeutic intervention. Serotonin receptor signaling is altered by a number of drugs used to treat mood disorders such as depression and anxiety and psychiatric disorders including schizophrenia. For example, we recently found that a novel estrogen receptor system modifies serotonin receptor signaling and is a potential target for the treatment of depression and other mood disorders associated with the onset of menopause.
McAllister CE, Creech R, Kimball P, Muma NA, Li Q, GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus, Psychoneuroendocrinology, 37: 1248-60, 2012. IF: 5.17
Creech RD, Li Q, Carrasco GA, Van de Kar LD, Muma NA, Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1and Gαz, Neuropharmacology, 62: 2040-2049, 2012 IF: 4.68
Rossi DV, Dai Y, Thomas P, Carrasco GA, Doncarlos LL, Muma NA, Li Q. Estradiol-induced desensitization of 5-HT(1A) receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta. Psychoneuroendocrinology, 35:1023-33, PMID: 20138435, 2010. IF: 5.17
Xu, H, Qin, S, Carrasco GA, Dai Y, Filardo EJ, Prossnitz ER, Battaglia G, DonCarlos LL, Muma NA Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus. Neuroscience, 158:1599-607, PMID: 19095043, 2010. IF: 3.22
Shi J, Damjanoska KJ, Zemaitaitis BW, Garcia F, Carrasco G, Sullivan NR, She Y, Young KH, Battaglia G, Van de Kar LD, Muma NA: Alterations in 5-HT2A receptor signaling in male and female transgenic rats overexpressing either Gq or RGS-insensitive Gq protein. Neuropharmacology, 51: 524-535, 2006.
Grippo AJ, Sullivan NR, Damjanoska KJ, Crane JW, Carrasco, GA, Shi J, Chen Z, Garcia F, Muma NA and Van de Kar LD: Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats. Psychopharmacology, 179: 769-780, 2005.
D'Souza DN, Zhang Y, Damjanoska KJ, Carrasco GA, Sullivan NR, Garcia F, Battaglia G, DonCarlos LL, Muma NA and Van de Kar LD: Estrogen reduces serotonin-1A receptor-mediated oxytocin release and Gαi/o/z proteins in the hypothalamus of ovariectomized rats. Neuroendocrinology, 80: 31-41, 2004.
Rapp DK, DonCarlos LL, Garcia F, Zhang Y, Muma NA, Battaglia G and Van de Kar LD: Ovariectomy-induced increases in hypothalamic serotonin-1A receptor function in rats is prevented by estradiol. Neuroendocrinology, 76: 348-356, 2002.
Van de Kar LD, Raap DK, Battaglia G, Muma NA, Garcia F, Don Carlos LL:Treatment of cycling female rats with fluoxetine induces desensitization of hypothalamic 5-HT(1A) receptors with no change in 5-HT(2A) receptors. Neuropharmacology. 43:45-54, 2002
Raap DK, DonCarlos L, Garcia F, Muma NA, Wolf WA, Battaglia G and Van de Kar LD: Estrogen desensitizes 5-HT1A receptors and reduces levels of Gz, Gi1 and Gi3 proteins in the hypothalamus. Neuropharmacology, 39: 1823-1832, 2000.
Nancy A. Muma, PhD
Professor and Chair