Department of Anatomy and Physiology - Kansas State University
Ph.D., University of Pennyslvania, 1986
Postdoctoral, Michigan State University, 1986-1989
The KSU Stem Cell Biotechnology Research team has been focused upon characterizing non embryonic stem cells that they have discovered in the umbilical cord matrix and rat embryonic stem cell. We lead this group and organize research efforts.
To date, our published work indicates a propensity for the nonembryonic stem cells to differentiate along the neural lineage (Mitchell et al., 2003) and for these cells to engraft following xenografting into rats that are not receiving immune suppression treatment (Weiss et al., 2004; Medicetty et al. 2004). Currently, my laboratory is characterizing the role of human and animal umbilical cord matrix stem cells to reverse the behavioral deficits found in a rat model of Parkinson's disease.
My laboratory has also isolated and characterized rat embryonic stem cells. These stem cells are pluripotent and will be used to generate preclinical rat models for studying a variety of diseases.
Ferrer MS, Lutjemeier BJ, Koopman T, Pierucci-Alves F, Weiss ML. Xenogeneic transplantation of equine testicular cells into seminiferous tubules of immunocompetent rats. Theriogenology. 2011 Apr 15;75(7):1258-64.
Wang L, Ott L, Seshareddy K, Weiss ML, Detamore MS. Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells. Regen Med. 2011 Jan;6(1):95-109.
Wang L, Seshareddy K, Weiss ML, Detamore MS. Effect of initial seeding densityon human umbilical cord mesenchymal stromal cells for fibrocartilage tissue engineering. Tissue Eng Part A. 2009 May;15(5):1009-17.
Wang L, Tran I, Seshareddy K, Weiss ML, Detamore MS. A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering. Tissue Eng Part A. 2009 Aug;15(8):2259-66.
He H, McHaney M, J Hong J, Weiss ML. Cloning and characterization of 3.1kb promoter region of the Oct4 gene from the Fischer 344 rat. The Open Stem Cell Journal, 2009, 1, 30-39.
Rachakatla RS, Pyle MM, Ayuzawa R, Edwards SM, Marini FC, Weiss ML, Tamura M, Troyer D. Combination treatment of human umbilical cord matrix stem cell-based interferon-beta gene therapy and 5-fluorouracil significantly reduces growth of metastatic human breast cancer in SCID mouse lungs. Cancer Invest. 2008 Aug;26(7):662-70.
Troyer DL, Weiss ML. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells. 2008 Mar;26(3):591-9.
Seshareddy K, Troyer D, Weiss ML. Method to isolate mesenchymal-like cells from Wharton's Jelly of umbilical cord. Methods Cell Biol. 2008;86:101-19.
Mark L. Weiss, Ph.D.