M.A. Karim Rumi, M.B.B.S., M.S., Ph.D.
Dept. of Pathology and Laboratory Medicine
Member, Center for Epigenetics and Stem Cell Biology
M.B.B.S., Dhaka Medical College, Dhaka University, Bangladesh, 1988
M.S., Instit. of Molecular Biology and Biotechnology, VUB, Belgium, 1993
Ph.D., Shimane Medical University, Japan, 2004
Postdoctoral, UT MD Anderson Cancer Center, Texas, 2006
Postdoctoral, University of Kansas Medical Center, Kansas, 2007
We are interested in transcriptional regulation of cell differentiation. One of our studies is related to early lineage determination during embryonic development. We investigate signaling pathways regulating trophoblast specific gene expression, trophoblast differentiation, and placental development. Our other study involves estrogen signaling in regulation of reproductive tract development and fertility. We are also involved in developing cell and animal model systems for related studies.
Rumi MA, Dhakal P, Kubota K, Chakraborty D, Lei T, Larson MA, Wolfe MW, Roby KF, Vivian JL and Soares MJ. Generation of Esr1 knockout rats using zinc finger nuclease-mediated genome editing. Endocrinology. 2014; 155(5):1991-9.
Renaud SJ, Kubota K, Rumi MA, Soares MJ. The FOS Transcription factor family differentially controls trophoblast migration and invasion. J Biol Chem. 2014; 289(8):5025-39.
Chuong EB, Rumi MA, Soares MJ, Baker JC. Endogenous retroviruses function as species-specific enhancer elements in the placenta. Nat Genet. 2013; 45(3):325-9.
Bhattacherjee A, Rumi MA, Staecker H, Smith PG. Bone morphogenetic protein 4 mediates estrogen-regulated sensory axon plasticity in the adult female reproductive tract. J Neurosci. 2013; 33(3):1050-61.
Asanoma K, Kubota K, Chakraborty D, Renaud SJ, Wake N, Fukushima K, Soares MJ, Rumi MA. SATB homeobox proteins regulate trophoblast stem cell renewal and differentiation. J Biol Chem. 2012; 287(3):2257-68.
Kent LN, Rumi MA, Kubota K, Lee DS, Soares MJ. FOSL1 is integral to establishing the maternal-fetal interface. Mol Cell Biol. 2011; 31(23):4801-13.
Chakraborty D, Rumi MA, Konno T, Soares MJ. Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions. Proc Natl Acad Sci U S A. 2011; 108(39):16295-300.
Asanoma K, Rumi MA, Kent LN, Chakraborty D, Renaud SJ, Wake N, Lee DS, Kubota K, Soares MJ. FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage. Dev Biol. 2011; 351(1):110-9.
Lee DS, Rumi MA, Konno T, Soares MJ. In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Genesis. 2009; 47(7):433-9.
Ray S, Dutta D, Rumi MA, Kent LN, Soares MJ, Paul S. Context-dependent function of regulatory elements and a switch in chromatin occupancy between GATA3 and GATA2 regulate Gata2 transcription during trophoblast differentiation. J Biol Chem. 2009; 284(8):4978-88.