Katherine Swenson Fields, Ph.D.

Research Associate Professor
Department of Anatomy and Cell Biology

Ph.D., University of Washington, Seattle, WA, 1983
Postdoctoral, Harvard Medical School, 1983-1989


kfields@kumc.edu

The research focus of our lab, shared with Dr. Timothy Fields, is centered on the Wnt signaling pathways that regulate stem cell differentiation and proliferative disease progression. We are currently studying the roles of the Wnts in human polycystic kidney disease. We have found that the cystic tubule epithelial cells from these patients have increased expression of the non-canonical Wnt, WNT5A, and have uncovered evidence that this Wnt acts to promote proliferation and cyst formation, thereby promoting disease progression. My current efforts are focused on directing this project to understand the stimulus that induces the upregulation of this Wnt in polycystic kidney disease, to identify the ensuing pro-proliferative signaling pathways that are triggered and to design, produce and validate specific Wnt signaling inhibitors for use as therapeutic interventions. For more information on our research, please visit the Swenson Fields web site.

Selected Publications

Grantham JJ, Mulamalla S and Swenson-Fields KI. (2011) Why kidneys fail in autosomal dominant polycystic kidney disease. Nature Reviews Nephrology 7:556-66.

Rossol-Allison J, Stemmle LN, Swenson-Fields KI, Kelly P, Fields PE, McCall SJ, Casey PJ, Fields TA. (2009) Rho GTPase activity modulates Wnt3a/beta-catenin signaling. Cell Signal21:1559-68.

Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR. (2008) MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. Mol Cell 32:43-56.

Sandquist JC, Swenson KI, Demali KA, Burridge K, Means AR. (2006) Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem 281:35873-83.

Last modified: Jan 14, 2013

Katherine Swenson Fields, Ph.D.

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Katherine Swenson Fields, Ph.D.
Research Associate Professor

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