Jinxi Wang, M.D., Ph.D.

Harrington Distinguished Professor
Director, Harrington Laboratory for Molecular Orthopedics
Department of Orthopedic Surgery

M.D., Suzhou Medical College, Suzhou, P.R. China, 1987
Ph.D., Suzhou Medical College and Loma Linda University, 1991
Postdoctoral, Harvard University Medical School, 1992-1996


jwang@kumc.edu

My major research interests are to study the regulatory mechanisms by which pluripotent mesenchymal stem cells differentiate into osteoblasts (bone-forming cells) or chondrocytes (cartilage-forming cells) and investigate the role of specific signaling pathways in bone/cartilage regeneration and diseases.  Currently, research in my laboratory is focused on the following areas: (1) the role of bone sialoprotein (BSP) in osteoblast differentiation and bone regeneration, (2) molecular regulation of chondrocyte differentiation and articular cartilage regeneration, and (3) pathogenetic mechanisms and novel therapeutics for osteoarthritis.

Selected Publications

Kramer WC, Hendricks KJ, Wang J. Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention. Int J Clin Exp Med. 2011 Nov; 4(4):285-98.

Rodova M, Lu Q, Li Y, Woodbury BG, Crist JD, Gardner BM, Yost JG, Zhong XB, Anderson HC, Wang J. Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation. J Bone Miner Res. 2011 Aug; 26(8):1974-86.

Schroeppel JP, Crist JD, Anderson HC, Wang J. Molecular regulation of articular chondrocyte function and its significance in osteoarthritis. Histol Histopathol. 2011 Mar; 26(3):377-94.

Wang Q, Wang J, Lu Q, Detamore MS, Berkland C. Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects. Biomaterials. 2010 Jun; 31(18):4980-6.

Wang J, Gardner BM, Lu Q, Rodova M, Woodbury BG, Yost JG, Roby KF, Pinson DM, Tawfik O, Anderson HC. Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes. J Pathol. 2009 Oct; 219(2):163-72.

Xu L, Anderson AL, Lu Q, Wang J. Role of fibrillar structure of collagenous carrier in bone sialoprotein-mediated matrix mineralization and osteoblast differentiation. Biomaterials. 2007 Feb; 28(4):750-61.

Wang J, Zhou HY, Salih E, Xu L, Wunderlich L, Gu X, Hofstaetter JG, Torres M, Glimcher MJ. Site-specific in vivo calcification and osteogenesis stimulated by bone sialoprotein. Calcif Tissue Int. 2006 Sep; 79(3):179-89.

Last modified: Feb 20, 2013

Jinxi Wang, M.D., Ph.D.

Contact

Jinxi Wang, M.D., Ph.D.
Harrington Distinguished Professor
Director, Harrington Laboratory for Molecular Orthopedics

ID=x1673