David F. Albertini, PhD

Professor
Editor-in-Chief, Journal of Assisted Reproduction and Genetics
Department of Molecular and Integrative Physiology

Ph.D., Harvard University, 1975
Postdoctoral: University of Connecticut, 1975-1977


dalbertini@kumc.edu

Our laboratory employs genetic, molecular and imaging strategies to study basic aspects of the process of reproduction that bear on human disease and its clinical management by stem cell therapy. The overall emphasis is on Women's Health in relation to causes of human infertility, ovarian cancer, and the deployment of Assisted Reproductive Technologies (ARTS) for improving egg and embryo quality in human and animal models. Three project areas are actively under study:

  1. Fertility Preservation-ameliorating the loss of fertility experienced by women undergoing radiation or chemotherapy is the goal of this research. Using our long standing interest in signaling between the somatic and germ cell components of the ovarian follicle, we have intiated projects that focus on (1) understanding the mechanisms that underlie DNA damage and repair in oocytes following chemotherapy or radiation induced damage; and (2) implementation of cryopreservation strategies for oocytes and ovarian tissues that could subsequently be used for embryo production.
  2. Cell Cycle Regulation In Oocytes and Embryos-how modifications in cell cycle checkpoint control ensure chromosome balance during meiosis in oocytes and mitosis in embryos is investigated by biochemical, live cell imaging, and pharmacological approaches that permit assessment of genomic integrity during cell cycle progression. This strategy is used to understand the effects of maternal aging and/or environmental chemicals (endocrine disruptors) on oocytes or embryos produced by ARTs (in vitro maturation, in vitro fertilization).
  3. Stem Cell Biology- stem cells derived from adult, embryonic, or iPS sources hold great promise for providing new insights into the origins of human disease and strategies for treatments. Improvements in derivation and maintenance of stem cell lines are needed for the utility of genetically stable cells capable of realizing these promises. Our lab studies human and rat embryonic stem cells by focusing on culture conditions that assure genetic stability during proliferation and differentiation into neural progenitors. We are exploring the role of the Notch signaling pathway in an effort to understand regulation of apoptotic, autophagic, and necrotic pathways mediated by the microtubule cytoskeleton.

Selected Publications

Gleicher N. McCulloh DH, Kushnir VA, Ganguly N, Barad DH, Goldman KN, Kushnir MM, Albertini DF, Grifo JA. Is there an androgen level threshold for aneuploidy risk in infertile women? Reprod Biol Endocrinol 2015;6:13:38.

Barad DH, Kushnir VA, Albertini D, Gleicher N. CDC analysis of ICSI/autism: association is not causation. Hum Reprod. 2015 Jul;30(7):1745-6. doi: 10.1093/humrep/dev104

Wu YG, Barad DH, Kushnir VA, Lazzaroni E, Wang Q, Albertini DF, Gleicher N. Aging-related premature luteinization of granulosa cells is avoided by early oocyte retrieval. J Endocrinol 2015;226(3)):167-80.

Kushnir VA, Barad DH, Albertini DF, Sarmon SK, Gleicher N. Outcomes of fresh and cryopreserved oocyte donation. JAMA 2015;314(6)623-4.

Gleicher N, Yu Y, Himaya E, Barad DH, Weghofer A, Wu YG, Albertini DF, Want VQ, Kushnir VA. Early decline in functional ovarian reserve in young women with low (CGGn<26) FMR1 gene alleles. Trans Res 2015;166(5):502-7.

Kushnir VA, Halevy N, Barad DH, Albertini DF, Gleicher N. Relative importance of AMH and androgens changes with aging among non-obese women with polycystic ovary syndrome. J Ovarian Res 2015;8(1):45.

Gleicher N, Vega, Darmon SK, Weghofer A, Barad DH, Wu YG, Wang Q, Zhang L, Albertini D, Kushnir VA. Live-birth rates in very poor prognosis patients who are defined as poor responders under the Bologna criteria with nonelective single embryo, two-embryo, and three or more embryos transferred. Fertil Steril 2015;104(6):1435-41.

Albertini, N Gleicher  A detour in the quest for oogonial stem cells: methods matter. Nat Med 2015;21(10):1126-7.

Lazzaroni-Tealdi E, Barad DH, Albertini DF, Yu Y, Kushnir VA, Russell H, Wu YG, Gleicher N. Oocyte scoring enhances embryo-scoring in predicting pregnancy chances with IVF where it counts most. PLoS ONE 2015;10(12:e014362.

Last modified: Apr 21, 2016

David F. Albertini, PhD

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David F. Albertini, PhD
Professor
Editor-in-Chief, Journal of Assisted Reproduction and Genetics

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