Benyi Li, Ph.D.

Associate Professor
Director of Basic Science Research
Department of Urology

M.D., Tongji Medical University, China, 1992
Ph.D., Fukui Medical University of Japan, 1997
Postdoctoral, Moffitt Cancer Center, 1998-2000
Postdoctoral, Baylor College of Medicine, 2000-2001


bli@kumc.edu

Critical to the prevention and treatment of urologic cancers is basic science research. In the Urologic laboratory at Kansas University Medical Center we are investigating the various causes of cancer. Dr. Benyi Li, M.D., PhD. received training in molecular biology and prostate cancer research in China, Japan, and Baylor College of Medicine,  Houston, TX. His interests focus on molecular pathways which cause prostate cancer to grow and metastasize. In addition, he has created an inducible Akt system to allow further study of the molecular mechanisms behind prostate cancer.

Selected Publications

Tang Y, Chen R, Huang Y, Li G, Huang Y, Chen J, Duan L, Zhu BT, Thrasher JB, Zhang X, Li B. Natural compound Alternol induces oxidative stress-dependent apoptotic cell death preferentially in prostate cancer cells. Mol Cancer Ther. 2014 Mar 31. [Epub ahead of print]

Liu WJ, Luo MN, Tan J, Chen W, Huang LZ, Yang C, Pan Q, Li B, Liu HF. Autophagy activation reduces renal tubular injury induced by urinary proteins. Autophagy. 2013 Nov 26;10(2).

Chen R, Zeng X, Zhang R, Huang J, Kuang X, Yang J, Liu J, Tawfik O, Brantley Thrasher J, Li B. Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers. Urol Oncol. 2013 Sep 17. pii: S1078-1439(13)00243-3.

Yang J, Xie SX, Huang Y, Ling M, Liu J, Ran Y, Wang Y, Thrasher JB, Berkland C, Li B. Prostate-targeted biodegradable nanoparticles loaded with androgen receptor 1 silencing constructs eradicate xenograft tumors in mice. Nanomedicine (Lond). 2012 Sep; 7(9):1297-309.

Zhao Y, Duan S, Zeng X, Liu C, Davies NM, Li B, Forrest ML. Prodrug strategy for PSMA-targeted delivery of TGX-221 to prostate cancer cells. Mol Pharm. 2012 Jun 4;9(6):1705-16. Epub 2012 May 1.

Yao K, Youn H, Gao X, Huang B, Zhou F, Li B, Han H. Casein kinase 2 inhibition attenuates androgen receptor function and cell proliferation in prostate cancer cells. The Prostate. 2012 Sep 15; 72(13):1423-30.

Cai Z, Li B, Li K, Zhao B. Down-Regulation of Amyloid-β Through AMPK Activation by Inhibitors of GSK-3β in SH-SY5Y and SH-SY5Y-AβPP695 Cells. J Alzheimers Dis. 2012; 29(1):89-98.

Chen P, Yu J, Chalmers B, Drisko J, Yang J, Li B, Chen Q. Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy. Anticancer Drugs. 2011 23(4):437-44..

Tai W, Shukla RS, Qin B, Li B, Cheng K.  Development of a peptide-drug conjugate for prostate cancer therapy.  Molecular Pharmaceutics, 2011 Jun 6;8(3):901-12.

  

Last modified: Jun 25, 2014

Benyi Li, M.D., PhD.

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Benyi Li, Ph.D.
Associate Professor
Director of Basic Science Research

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