Arindam Paul, PhD

Research Assistant Professor
Dept. of Pathology and Laboratory Medicine
Member, Center for Epigenetics and Stem Cell Biology

PhD, Jadavpur University, Kolkata, India, 2005
Postdoctoral, University of Wisconsin, 2005-2009
Postdoctoral, University of Kansas Medical Center, 2009-2010


apaul2@kumc.edu

My long-term research interest is on some key problems in the area of developmental biology and cancer biology described below.

Neuronal commitment of rat embryonic stem (ES) cells as well as induced pluripotent (iPS) cells.
In this project, we are trying to develop serum free in vitro culture conditions to generate neural progenitors and terminally differentiated neural cell lines such as motor neurons, oligodendrocytes, astrocytes from rat ES and iPS cells.

Development of Novel Therapeutic Strategy to prevent breast cancer metastasis of targeting different signaling mechanism. We are evaluating small molecule compounds targeting different signaling pathways for regulation of epithelial mesenchymal transition, invasion and metastasis of triple negative breast cancer cells using both in vitro assay systems and in vivo conditions

Identification of novel therapeutic targets to prevent Invasive Breast Cancer development.
We are pursuing genome wide screening approach to identify novel regulators at various stages of invasive breast cancer development under in vivo conditions. The long term goal for this project is to develop small molecule compounds for future therapeutic modality to prevent invasive breast cancer development.

Selected Publications

Home, P., Saha, B., Ray, S., Dutta, D., Gunewardena, S., Yoo, B., Pal, A., Vivian, J.L., Larson, M., Petroff, M., Gallagher, P.G., Schulz, V., Golos, T.G., Behr, B., Paul, S. (2012) Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment. Proc. Natl. Acad. Sci. USA 109(19):7362-67.

Stecklein, S., Jensen, R.A., Pal, A. (2011) Genetic and Epigenetic Signatures of Breast Cancer Subtypes. Front Biosci 1;4:934-49.

Pal, A., Valdez, K., Ziegler, M., Behbod, F. (2010) Targeting the Perpetrator: Cancer Stem Cell Therapeutics. Curr Drug Targets 11(9): 1147-56

  

Last modified: Feb 24, 2014

Contact

Arindam Paul, PhD
Research Assistant Professor
Dept. of Pathology and Laboratory Medicine

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