Department of Psychiatry and Behavioral Sciences
Ph.D., University of California, 2000
Postdoctoral, The Scripps Research Institute, 2000-2002
Dr. Ann Manzardo is a Behavioral Pharmacologist who specializes in the field of addiction research. She has advanced training in biostatistics and expertise in the epidemiology of alcoholism. Dr. Manzardo has established a translational research program in the Department of Psychiatry and Behavioral Sciences through which she has directed funded research projects on alcoholism spanning multiple scientific disciplines: clinical, epidemiological and genetic. Her research has emphasized the study of gender disparate effects of inherited biological and neurodevlopmental risk factors for the development of alcoholism. And the role of thiamine deficiency in alcohol abuse behaviors. Dr. Manzardo has continued the tradition of collaborative study of the Danish Perinatal Cohort in the Department of Psychiatry with her studies of the influence of premature birth on the development of alcoholism. Dr. Manzardo has also recently expanded her research interests to include bioinformatics as it is applied to the genetics of alcoholism.
Madarasz W, Manzardo AM, Mortensen EL, Penick EC, Knop J, Sorensen HJ, Becker U, Nickels EJ, Gabrielli WF: 45-year Mortalilty Rate as a Function of the Number and Type of Psychiatric Diagnosis Found in a Large Danish Birth Cohort, Canadian Journal of Psychiatry,2012 Aug;57(8):505-511.
Manzardo AM, Henkhaus R, Butler MG: Genome-Wide Promoter Methylation in Frontal Cortex of Alcoholics and Controls, Gene, Apr, 498(1): 5-12, 2012.
Manzardo AM, Henkhaus R, Dhillon S, Butler MG: Reduction of Cytokine Levels in Children with Classical Autism, International Journal of Developmental Neuroscience, Apr, 30(2): 121-7, 2012.
Manzardo AM, Henkhaus R, Hidakka B, Penick EC, Poje A, Butler MG: X Chromosome Inactivation in Blood from Women with Alcoholism, Alcoholism Clinical and Experimental Research, Feb 29, 2012.
Manzardo AM, Madarasz W, Penick EC, Knop J, Mortensen EL, Sorensen HJ, Mahnken J, Becker U, Nickels EJ, Gabrielli WF: Effects of Premature Birth on the Risk for Alcoholism are Greater in Males than Females, Journal of Studies on Alcohol and Drugs, May; 72(3):390-98, 2011.
Knop J, Penick EC, Nickels EJ, Mortensen EL, Mednick SA, Jensen P, Manzardo AM, Gabrielli WF: Childhood ADHD and Conduct Disorder as Independent Predictors of Male Alcohol Dependence at Age 40. Journal of Studies on Alcohol and Drugs, Mar; 70(2):169-77, 2009.
Knop J, Penick EC, Nickels EJ, Mednick SA, Jensen P, Manzardo AM, Gabrielli WF: Paternal alcoholism predicts the occurrence but not the remission of alcoholic drinking: A forty-year follow-up, Acta Psychiatrica Scandinavia, Nov, 116(5): 386-393, 2007.
Manzardo AM, Penick EC: A theoretical argument for inherited thiamine insensitivity as one possible biological cause of familial alcoholism. Alcoholism: Clinical and Experimental Research, Sep, 30(9):1545-1550, 2006.
Manzardo AM, Penick EC, Knop J, Nickels EJ, Hall S, Jensen P, Gabrielli WF: Developmental differences in childhood motor coordination predict adult alcohol dependence: Proposed role for the cerebellum in alcoholism. Alcoholism: Clinical and Experimental Research. 29(3):353-357, 2005.
Manzardo AM, Penick EC, Knop J, Nickels EJ, Hall S, Miller C, Jensen P, Gabrielli WF: Neonatal vitamin K might reduce vulnerability to alcohol dependence in Danish men, Journal on Studies of Alcohol, Sep, 66:586-592, 2005.
Ann M. Manzardo, Ph.D., MSCR