Dept. of Pharmacology & Toxicology, The University of Kansas-Lawrence
Ph.D., University of British Columbia, Vancouver, Canada, 2000
Postdoctoral, University of British Columbia, University of Washington, Case Western Reserve University, 2000-2007
My group's research deals with the mechanisms by which cells within a multicellular organism communicate with one another to orchestrate cell differentiation and function. Our work focuses on short range cellular signaling events that are carried out by the vitamin A metabolite, retinoic acid. Retinoic acid activates its cognate Retinoic Acid Receptor and thereby plays critical roles in many basic life processes including fetal development, cellular differentiation and metabolism, reproduction, bone growth, blood clotting, immunity and behavior. By using both genetic and pharmacological approaches we are currently studying the role of various enzymes and pathways responsible for the metabolism and transport of vitamin A and its metabolites within fetal tissues. Our immediate goals is to further establish the processes responsible for the regulation of retinoic formation and to contribute to a framework for the long-term goal of developing approaches to prevent and treat disorders associated with altered retinoic acid signaling.
Batten M L, Imanishi Y, Maeda T, Tu D C, Moise A R, Bronson D, Possin D, Van Gelder R N, Baehr W, and Palczewski K. (2004) Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem 279, 10422-10432.
Batten M L, Imanishi Y, Tu D C, Doan T, Zhu L, Pang J, Glushakova L, Moise A R, Baehr W, Van Gelder R N, Hauswirth W W, Rieke F, and Palczewski K. (2005) Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med 2, e333.
Moise A R, Kuksa V, Blaner W S, Baehr W, and Palczewski K. (2005) Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem 280, 27815-27825.
Moise A R, Noy N, Palczewski K, and Blaner W S. (2007) Delivery of retinoid-based therapies to target tissues. Biochemistry 46, 4449-4458.
Travis G H, Golczak M, Moise A R, and Palczewski K. (2007) Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents, Ann. Rev. Pharmacol. Toxicol. 47, 469-512.
Lobo G P, Hessel S, Eichinger A, Noy N, Moise A R, Wyss A, Palczewski K, and von Lintig J. (2010) ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J 24, 1656-1666.
Moise A R, Lobo G P, Erokwu B, Wilson D L, Peck D, Alvarez S, Dominguez M, Alvarez R, Flask C A, de Lera A R, von Lintig J, and Palczewski K. (2010) Increased adiposity in the retinol saturase-knockout mouse. FASEB J 24, 1261-1270.
Billings S E, Pierzchalski K, Butler Tjaden N E, Pang X Y, Trainor P A, Kane M A, and Moise A R. (2013) The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J 27, 4877-4889.
Alexander R. Moise, Ph.D.