Research

We have been engaged in bench-to-bedside research on infectious diseases for more than 50 years, since Dr. Chien Liu, professor emeritus of medicine - widely recognized as one of the physician scientists who helped discover the etiology of primary atypical pneumonia - founded our division in 1958.

Our Infectious Diseases Clinical Research Program is currently directed by Dr. Lisa Clough and focuses on the safety and effectiveness of anti-microbial treatments; therapeutic and prophylactic vaccines; the study of influenza, HIV and other viruses; the mechanisms of disease production in pneumococcal infections; stem cell transplant and complicated lung infections. We are carrying out a variety of NIH and independently funded trials, as well as investigator-initiated endeavors.

Current Research


NIH Funded
Title PI/Sub Status
2009-2012 An Observational Study of the Clinical and Virologic Manifestations of Novel and Seasonal Influenza Clough Completed
1999-2012 A Phase III Double-Blind, Placebo-Controlled Trial of Long Term Therapy of Herpes Simplex Encephalitis (HSE): An Evaluation of Valacyclovir Hinthorn Completed
2006-2011 ART Adherence: Enhanced Counseling And Observed
Therapy
Clough Completed

 

Industry Sponsored
Title PI/Sub Status
2012-present DEFLECT-1: A Phase 3b Multi-Center, Double-Blind Randomized, Placebo Controlled Study to Demonstrate the Safety and Efficacy of Fidaxomicin for Prophylaxis Against Clostridium difficile Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation Clough Start Up
2012-present A Phase III, Randomized, Double-Blind,
Placebo-Controlled Study of the Efficacy, Safety and Tolerability of a Single Infusion of MK-6072 (Human Monoclonal Antibody to C. difficile toxin B), and MK-3415A (Human Monoclonal Antibodies to C. difficile toxin A and B) in Patients Receiving Antibiotic Therapy for C. difficile Infection (MODIFY II)
Clough Enrollment   Underway
2012-present Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension (SCH 56592) in Subjects at High Risk for Invasive Fungal Infections Clough Enrollment  Completed
2010-2011 Clostridium Difficile Toxoid Vaccine: A Phase II Randomized, Placebo-Controlled, Double-blind, Dose Ranging Study to Assess the Immunogenicity and Safety of a Clostridium Difficile Toxoid Vaccine in Subjects with Clostridium Difficile Infection (CDI). Clough Completed
2010-2011 A Randomized, Double-Blinded, Active-Controlled, Dose Ranging Study of Study Antibiotic in Patients with Clostridium Difficile Infection. Clough: Sub-I Completed

 

Investigator Initiated
TitlePI/SubStatus
2011-present Vancomycin Nephrotoxicity in the Outpatient Setting: High Trough Dosing Versus Standard Trough Dosing Regimens Hammoud Data Collection Underway
2011-present Trends in Invasive Pneumococcal Disease in Adults
in a Major Teaching Hospital in the Midwest
Merino
Clough
Data Collection Underway
2011-present A Retrospective Review of Respiratory Viral Pathogen
Infections in a Hospitalized Hematopoetic Stem Cell Transplant (HSCT) Population at the University of Kansas Medical Center
Hawkinson
Pandeya
Clough
Data Analysis
Underway
2011-present Yield of Sonicated Cultures in Diagnosing Orthopaedic
Hardware Infection.
El Atrouni
Khumri
Data Analysis
Underway
2011-present A Validation of Prediction Model for Cardiovascular Implantable Electronic Device-Related Infections and Infective Endocarditis El Atrouni
Chaung
Clough
Data Analysis
Underway
2011-present A Retrospective Review of a Comprehensive Cohort of Candidal Septic Shock: Impact of Antifungal Therapy on Outcome Clough
Newman
Data Analysis
Underway
2009-present A Retrospective Review of the Incidence of Ocular Candidiasis in Candida Bloodstream Infection Eid
Khalid
Clough
Data Analysis Underway
2009-present Immune Response after Monovalent Influenza A (H1N1) 2009 Vaccine in Hemodialysis Patients Clough Data Analysis Underway
2008-present Evaluation of Antigen Detection for Diagnosis of Histoplasmosis and Blastomycosis Hammoud Data Analysis Underway
2010-2011 Pre-emptive Treatment with Rituximab for Epstein-Barr Virus Reactivation after Allogenic Hematopoietic Stem Cell Transplantation: A Safety and Efficacy Study Ganguly, N.
Maalouf
Clough
Completed
2009-2011 Use of Cidofovir in the Treatment of BK Virus Infection in Patients Undergoing Allogenic Stem Cell Transplantation Ganguly, N.
Clough
Completed
2008-2011 Exploring the Use of a Novel Device for Reducing Catheter-related Bloodstream Infections Waller       Clough Completed
2009-2010 Clinical and Laboratory Features Predicting Abdominal Abscess in Patients with Post-Liver (OLT) Transplant Fluid Collections Waller
Eid
Clough
Completed
2008-2010 A Comparative Study of Incidence and Spectrum of Infections in Patients with Chronic Graft Versus Host Disease (GVHD) before, during, and after Extracorporeal Photopheresis (ECP). BMT
Ganguly, N.
Clough
Completed
2007-2009 Routine Use of a Whole Blood Interferon-γ Assay for the Diagnosis of Mycobacterium Tuberculosis at a Tertiary-Care University-Affiliated Hospital. Clough
Hammoud
Completed
2007-2009 A Retrospective Review of Candida Bloodstream Infection in a Tertiary Medical Center. Time to Initiation of Appropriate Antifungal Therapy and its Association with Outcome. Clough Completed

 

Basic Science Device Development
Title PI/Sub Status
2011-present Development of Novel Medical Device Removal System Waller Data Collection Underway
2010-present Development of Medication Delivery Device Waller                 Data Collection Underway

 

Basic Science Infection Prevention
Title PI/Sub Status
2011-present Prevention of Early Wound Infection Waller
Clough
Newman
Data Analysis Underway

Last modified: Oct 02, 2012
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