Research

We have been engaged in bench-to-bedside research on infectious diseases for more than 50 years, since Dr. Chien Liu, professor emeritus of medicine - widely recognized as one of the physician scientists who helped discover the etiology of primary atypical pneumonia - founded our division in 1958.

Our Infectious Diseases Clinical Research Program is currently directed by Dr. Lisa Clough and focuses on the safety and effectiveness of anti-microbial treatments; therapeutic and prophylactic vaccines; the study of influenza, HIV and other viruses; the mechanisms of disease production in pneumococcal infections; stem cell transplant and complicated lung infections. We are carrying out a variety of NIH and independently funded trials, as well as investigator-initiated endeavors.

Current Research


NIH Funded
TitlePI/SubStatus
2016-Present A Phase II Multi-Center, Prospective, Randomized, Double-Blind Study to Assess the Clinical and Antiviral Efficacy and Safety of Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients Clough Upcoming

 

Industry Sponsored
TitlePI/SubStatus
2016-Present A Phase 3, Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Switching from Regimens Consisting of Boosted Atazanavir or Darunavir plus either Emtricitabine/Tenofovir or Abacavir/Lamivudine to GS-9883/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed HIV-1 Infected Adults  Clough Follow-up / Closed to enrollment
2015-Present A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hospitalized Adults with Respiratory Syncytial Virus (RSV) Infection Clough Actively Enrolling

 

Investigator Initiated
TitlePI/SubStatus
2016-present Infection Outcomes in 2 Stage Revision Total Knee Arthroplasty at The University of Kansas Medical Center. Association with Post-Operative Antibiotic Use Clough In Progress
2016-Present Cumulative and current exposure to antiretrovirals and development of CKD el Atrouni
Pacholec

In Progress
2015-Present Incidence and Spectrum of Infection and Its Outcome after Umbilical Cord Blood Transplantation in Patients with Hematological Malignancies: A single center experience Ganguly Data Analysis Underway

 


Past Research

NIH Funded
TitlePI/Sub
2009-2012 An Observational Study of the Clinical and Virologic Manifestations of Novel and Seasonal Influenza Clough
1999-2012 A Phase III Double-Blind, Placebo-Controlled Trial of Long Term Therapy of Herpes Simplex Encephalitis (HSE): An Evaluation of Valacyclovir Hinthorn
2006-2011 ART Adherence: Enhanced Counseling And Observed
Therapy
Clough

 

Industry Sponsored
TitlePI/Sub
2014-2016 A Phase III Randomized, Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of MK-8228 (Letermovir) for the Prevention of Clinically Significant Human Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients Clough
2014-2016 A Phase II, Randomized, Double-blind, Placebo-controlled study to examine the effects of DAS181 in immunocompromised subjects with Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxygen Clough
2012-2014 DEFLECT-1: A Phase 3b Multi-Center, Double-Blind Randomized, Placebo Controlled Study to Demonstrate the Safety and Efficacy of Fidaxomicin for Prophylaxis Against Clostridium difficile Associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation Clough
2012-2015 A Phase III, Randomized, Double-Blind,
Placebo-Controlled Study of the Efficacy, Safety and Tolerability of a Single Infusion of MK-6072 (Human Monoclonal Antibody to C. difficile toxin B), and MK-3415A (Human Monoclonal Antibodies to C. difficile toxin A and B) in Patients Receiving Antibiotic Therapy for C. difficile Infection (MODIFY II)
Clough
2012-2014 Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension (SCH 56592) in Subjects at High Risk for Invasive Fungal Infections Clough
2010-2011 Clostridium Difficile Toxoid Vaccine: A Phase II Randomized, Placebo-Controlled, Double-blind, Dose Ranging Study to Assess the Immunogenicity and Safety of a Clostridium Difficile Toxoid Vaccine in Subjects with Clostridium Difficile Infection (CDI). Clough
2010-2011 A Randomized, Double-Blinded, Active-Controlled, Dose Ranging Study of Study Antibiotic in Patients with Clostridium Difficile Infection. Clough: Sub-I

 

Investigator Initiated
TitlePI/Sub
2015 - 2016 Survey of healthcare workers (HCWs) in a Midwestern tertiary care center regarding HIV transmission risk and their opinions about HIV positive healthcare workers el Atrouni
Petrey
2011-2013 Vancomycin Nephrotoxicity in the Outpatient Setting: High Trough Dosing Versus Standard Trough Dosing Regimens     PubMed Hammoud
2011-2013 Trends in Invasive Pneumococcal Disease in Adults
in a Major Teaching Hospital in the Midwest
Merino
Clough
2011-2013 A Retrospective Review of Respiratory Viral Pathogen
Infections in a Hospitalized Hematopoetic Stem Cell Transplant (HSCT) Population at the University of Kansas Medical Center
Hawkinson
Pandeya
Clough
2011-2013 Yield of Sonicated Cultures in Diagnosing Orthopaedic
Hardware Infection.
El Atrouni
Khumri
2011-2013 A Validation of Prediction Model for Cardiovascular Implantable Electronic Device-Related Infections and Infective Endocarditis El Atrouni
Chaung
Clough
2011-2013 A Retrospective Review of a Comprehensive Cohort of Candidal Septic Shock: Impact of Antifungal Therapy on Outcome Clough
Newman
2009-2011 A Retrospective Review of the Incidence of Ocular Candidiasis in Candida Bloodstream Infection Eid
Khalid
Clough
2009-2011 Immune Response after Monovalent Influenza A (H1N1) 2009 Vaccine in Hemodialysis Patients Clough
2008-2010 Evaluation of Antigen Detection for Diagnosis of Histoplasmosis and Blastomycosis Hammoud
2010-2011 Pre-emptive Treatment with Rituximab for Epstein-Barr Virus Reactivation after Allogenic Hematopoietic Stem Cell Transplantation: A Safety and Efficacy Study Ganguly, N.
Maalouf
Clough
2009-2011 Use of Cidofovir in the Treatment of BK Virus Infection in Patients Undergoing Allogenic Stem Cell Transplantation Ganguly, N.
Clough
2008-2011 Exploring the Use of a Novel Device for Reducing Catheter-related Bloodstream Infections Waller       Clough
2009-2010 Clinical and Laboratory Features Predicting Abdominal Abscess in Patients with Post-Liver (OLT) Transplant Fluid Collections Waller
Eid
Clough
2008-2010 A Comparative Study of Incidence and Spectrum of Infections in Patients with Chronic Graft Versus Host Disease (GVHD) before, during, and after Extracorporeal Photopheresis (ECP). BMT
Ganguly, N.
Clough
2007-2009 Routine Use of a Whole Blood Interferon-γ Assay for the Diagnosis of Mycobacterium Tuberculosis at a Tertiary-Care University-Affiliated Hospital. Clough
Hammoud
2007-2009 A Retrospective Review of Candida Bloodstream Infection in a Tertiary Medical Center. Time to Initiation of Appropriate Antifungal Therapy and its Association with Outcome. Clough

 

Basic Science Device Development
TitlePI/Sub
2011-2013 Development of Novel Medical Device Removal System Waller
2010-2013 Development of Medication Delivery Device Waller                

 

Basic Science Infection Prevention
TitlePI/Sub
2011-2012 Prevention of Early Wound Infection Waller
Clough
Newman

Last modified: Oct 02, 2012
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